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5YE5

structure of endo-lysosomal TRPML1 channel inserting into nanodisc

Summary for 5YE5
Entry DOI10.2210/pdb5ye5/pdb
EMDB information6826
Descriptormammalian endo-lysosomal TRPML1 channel, 2-acetamido-2-deoxy-beta-D-glucopyranose (2 entities in total)
Functional Keywordsmtrpml1, mucolipidosis type iv, structual comparisons, combined regulation mechanism, membrane protein
Biological sourceMus musculus (Mouse)
Cellular locationCell membrane ; Multi-pass membrane protein : Q99J21
Total number of polymer chains4
Total formula weight264064.13
Authors
Yang, M.,Gao, N. (deposition date: 2017-09-15, release date: 2017-11-15, Last modification date: 2020-07-29)
Primary citationZhang, S.,Li, N.,Zeng, W.,Gao, N.,Yang, M.
Cryo-EM structures of the mammalian endo-lysosomal TRPML1 channel elucidate the combined regulation mechanism
Protein Cell, 8:834-847, 2017
Cited by
PubMed: 28936784
DOI: 10.1007/s13238-017-0476-5
PDB entries with the same primary citation
Experimental method
ELECTRON MICROSCOPY (5.8 Å)
Structure validation

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