6E7Z
cryo-EM structure of human TRPML1 with ML-SA1 and PI35P2
Summary for 6E7Z
Entry DOI | 10.2210/pdb6e7z/pdb |
EMDB information | 9002 |
Descriptor | Mucolipin-1, (1R,2S,3S,4R,5S,6R)-5-{[(R)-[(2R)-2,3-bis{[(1S)-1-hydroxyoctyl]oxy}propoxy](hydroxy)phosphoryl]oxy}-2,4,6-trihydroxycyclohexane-1,3-diyl bis[dihydrogen (phosphate)], 2-{2-oxo-2-[(4S)-2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl]ethyl}-1H-isoindole-1,3(2H)-dione (3 entities in total) |
Functional Keywords | human trpml1, membrane protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 264792.06 |
Authors | |
Primary citation | Fine, M.,Schmiege, P.,Li, X. Structural basis for PtdInsP2-mediated human TRPML1 regulation. Nat Commun, 9:4192-4192, 2018 Cited by PubMed: 30305615DOI: 10.1038/s41467-018-06493-7 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.73 Å) |
Structure validation
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