6E7Z

cryo-EM structure of human TRPML1 with ML-SA1 and PI35P2

Summary for 6E7Z

Entry DOI	10.2210/pdb6e7z/pdb
EMDB information	9002
Descriptor	Mucolipin-1, (1R,2S,3S,4R,5S,6R)-5-{[(R)-[(2R)-2,3-bis{[(1S)-1-hydroxyoctyl]oxy}propoxy](hydroxy)phosphoryl]oxy}-2,4,6-trihydroxycyclohexane-1,3-diyl bis[dihydrogen (phosphate)], 2-{2-oxo-2-[(4S)-2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl]ethyl}-1H-isoindole-1,3(2H)-dione (3 entities in total)
Functional Keywords	human trpml1, membrane protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	264792.06
Authors	Schmiege, P.,Li, X. (deposition date: 2018-07-27, release date: 2018-11-28)
Primary citation	Fine, M.,Schmiege, P.,Li, X. Structural basis for PtdInsP2-mediated human TRPML1 regulation. Nat Commun, 9:4192-4192, 2018 Cited by PubMed: 30305615 DOI: 10.1038/s41467-018-06493-7 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.73 Å)

Structure validation