6E7P

cryo-EM structure of human TRPML1 with PI35P2

Summary for 6E7P

Entry DOI	10.2210/pdb6e7p/pdb
EMDB information	9000
Descriptor	Mucolipin-1, (1R,2S,3S,4R,5S,6R)-5-{[(R)-[(2R)-2,3-bis{[(1S)-1-hydroxyoctyl]oxy}propoxy](hydroxy)phosphoryl]oxy}-2,4,6-trihydroxycyclohexane-1,3-diyl bis[dihydrogen (phosphate)] (2 entities in total)
Functional Keywords	human trpml1, membrane protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	263342.38
Authors	Schmiege, P.,Li, X. (deposition date: 2018-07-27, release date: 2018-11-28)
Primary citation	Fine, M.,Schmiege, P.,Li, X. Structural basis for PtdInsP2-mediated human TRPML1 regulation. Nat Commun, 9:4192-4192, 2018 Cited by PubMed: 30305615 DOI: 10.1038/s41467-018-06493-7 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.5 Å)

Structure validation