3QB4
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CRYSTAL STRUCTURE OF A TGF-BETA LIGAND-RECEPTOR COMPLEX
Descriptor:Growth/differentiation factor 5, Bone morphogenetic protein receptor type-1A
Authors:Mueller, T.D., Nickel, J., Sebald, W.
Deposit date:2011-01-12
Release date:2012-03-14
Last modified:2015-10-07
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:GDF-5 can act as a context-dependent BMP-2 antagonist.
Bmc Biol., 13, 2015
3NH7
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CRYSTAL STRUCTURE OF THE NEUTRALIZING FAB FRAGMENT ABD1556 BOUND TO THE BMP TYPE I RECEPTOR IA
Descriptor:Antibody fragment Fab AbD1556, heavy chain, light chain, ...
Authors:Mueller, T.D., Harth, S., Sebald, W.
Deposit date:2010-06-14
Release date:2010-10-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:A selection fit mechanism in BMP receptor IA as a possible source for BMP ligand-receptor promiscuity
Plos One, 5, 2010
3KFD
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TERNARY COMPLEX OF TGF-B1 REVEALS ISOFORM-SPECIFIC LIGAND RECOGNITION AND RECEPTOR RECRUITMENT IN THE SUPERFAMILY
Descriptor:Transforming growth factor beta-1, TGF-beta receptor type-2, TGF-beta receptor type-1
Authors:Radaev, S., Sun, P.D.
Deposit date:2009-10-27
Release date:2010-03-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.995 Å)
Cite:Ternary complex of transforming growth factor-beta1 reveals isoform-specific ligand recognition and receptor recruitment in the superfamily.
J.Biol.Chem., 285, 2010
3EVS
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CRYSTAL STRUCTURE OF THE GDF-5:BMP RECEPTOR IB COMPLEX.
Descriptor:Growth/differentiation factor 5, Bone morphogenetic protein receptor type-1B
Authors:Kotzsch, A., Mueller, T.D.
Deposit date:2008-10-13
Release date:2009-03-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure analysis reveals a spring-loaded latch as molecular mechanism for GDF-5-type I receptor specificity.
Embo J., 28, 2009
2QJB
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CRYSTAL STRUCTURE ANALYSIS OF BMP-2 IN COMPLEX WITH BMPR-IA VARIANT IA/IB
Descriptor:Bone morphogenetic protein 2, Bone morphogenetic protein receptor type IA, CHLORIDE ION
Authors:Kotzsch, A., Mueller, T.D.
Deposit date:2007-07-06
Release date:2008-01-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure analysis of bone morphogenetic protein-2 type I receptor complexes reveals a mechanism of receptor inactivation in juvenile polyposis syndrome.
J.Biol.Chem., 283, 2008
2QJA
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CRYSTAL STRUCTURE ANALYSIS OF BMP-2 IN COMPLEX WITH BMPR-IA VARIANT B12
Descriptor:Bone morphogenetic protein 2, Bone morphogenetic protein receptor type IA
Authors:Kotzsch, A., Mueller, T.D.
Deposit date:2007-07-06
Release date:2008-01-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure analysis of bone morphogenetic protein-2 type I receptor complexes reveals a mechanism of receptor inactivation in juvenile polyposis syndrome.
J.Biol.Chem., 283, 2008
2QJ9
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CRYSTAL STRUCTURE ANALYSIS OF BMP-2 IN COMPLEX WITH BMPR-IA VARIANT B1
Descriptor:Bone morphogenetic protein 2, Bone morphogenetic protein receptor type IA
Authors:Kotzsch, A., Mueller, T.D.
Deposit date:2007-07-06
Release date:2008-01-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.44 Å)
Cite:Structure analysis of bone morphogenetic protein-2 type I receptor complexes reveals a mechanism of receptor inactivation in juvenile polyposis syndrome.
J.Biol.Chem., 283, 2008
2PJY
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STRUCTURAL BASIS FOR COOPERATIVE ASSEMBLY OF THE TGF-BETA SIGNALING COMPLEX
Descriptor:Transforming growth factor beta-3, TGF-beta receptor type-2, TGF-beta receptor type-1
Authors:Groppe, J., Zubieta, C.
Deposit date:2007-04-16
Release date:2008-02-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Cooperative assembly of TGF-beta superfamily signaling complexes is mediated by two disparate mechanisms and distinct modes of receptor binding.
Mol.Cell, 29, 2008
2L5S
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SOLUTION STRUCTURE OF THE EXTRACELLULAR DOMAIN OF THE TGF-BETA TYPE I RECEPTOR
Descriptor:TGF-beta receptor type-1
Authors:Zuniga, J.E., Ilangovan, U., Pardeep, M., Hinck, C., Huang, T.
Deposit date:2010-11-04
Release date:2011-10-26
Method:SOLUTION NMR
Cite:The TbetaR-I Pre-Helix Extension Is Structurally Ordered in the Unbound Form and Its Flanking Prolines Are Essential for Binding
J.Mol.Biol., 412, 2011
2K3G
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NMR STRUCTURE ANALYSIS OF A BMP RECEPTOR
Descriptor:Bone morphogenetic protein receptor type-1A
Authors:Klages, J., Kotzsch, A., Mueller, T., Kessler, H.
Deposit date:2008-05-07
Release date:2008-12-16
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The solution structure of BMPR-IA reveals a local disorder-to-order transition upon BMP-2 binding.
Biochemistry, 47, 2008
2HLR
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CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF THE TYPE II BMP RECEPTOR
Descriptor:Bone morphogenetic protein receptor type-2
Authors:Mace, P.D., Cutfield, J.F., Cutfield, S.M.
Deposit date:2006-07-10
Release date:2006-11-28
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:High resolution structures of the bone morphogenetic protein type II receptor in two crystal forms: Implications for ligand binding
Biochem.Biophys.Res.Commun., 351, 2006
2HLQ
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CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF THE TYPE II BMP RECEPTOR
Descriptor:Bone morphogenetic protein receptor type-2
Authors:Mace, P.D., Cutfield, J.F., Cutfield, S.M.
Deposit date:2006-07-09
Release date:2006-11-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:High resolution structures of the bone morphogenetic protein type II receptor in two crystal forms: Implications for ligand binding
Biochem.Biophys.Res.Commun., 351, 2006
2H64
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CRYSTAL STRUCTURE OF A TERNARY LIGAND-RECEPTOR COMPLEX OF BMP-2
Descriptor:Bone morphogenetic protein 2, Bone morphogenetic protein receptor type IA, Acvr2b protein
Authors:Mueller, T.D., Sebald, W., Weber, D.
Deposit date:2006-05-30
Release date:2007-04-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:A silent H-bond can be mutationally activated for high-affinity interaction of BMP-2 and activin type IIB receptor.
Bmc Struct.Biol., 7, 2007
2H62
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CRYSTAL STRUCTURE OF A TERNARY LIGAND-RECEPTOR COMPLEX OF BMP-2
Descriptor:Bone morphogenetic protein 2, Bone morphogenetic protein receptor type IA, Acvr2b protein
Authors:Mueller, T.D.
Deposit date:2006-05-30
Release date:2007-04-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:A silent H-bond can be mutationally activated for high-affinity interaction of BMP-2 and activin type IIB receptor.
Bmc Struct.Biol., 7, 2007
2GOO
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TERNARY COMPLEX OF BMP-2 BOUND TO BMPR-IA-ECD AND ACTRII-ECD
Descriptor:Bone morphogenetic protein 2, Bone morphogenetic protein receptor type IA, Activin receptor type 2A, ...
Authors:Allendorph, G.P., Choe, S.
Deposit date:2006-04-13
Release date:2006-05-09
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of the ternary signaling complex of a TGF-beta superfamily member.
Proc.Natl.Acad.Sci.Usa, 103, 2006
1REW
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STRUCTURAL REFINEMENT OF THE COMPLEX OF BONE MORPHOGENETIC PROTEIN 2 AND ITS TYPE IA RECEPTOR
Descriptor:bone morphogenetic protein 2, bone morphogenetic protein receptor type IA
Authors:Keller, S., Nickel, J., Zhang, J.-L., Sebald, W., Mueller, T.D.
Deposit date:2003-11-07
Release date:2004-05-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.863 Å)
Cite:Molecular recognition of BMP-2 and BMP receptor IA.
Nat.Struct.Mol.Biol., 11, 2004
1ES7
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COMPLEX BETWEEN BMP-2 AND TWO BMP RECEPTOR IA ECTODOMAINS
Descriptor:BONE MORPHOGENETIC PROTEIN-2, BONE MORPHOGENETIC PROTEIN RECEPTOR IA
Authors:Kirsch, T., Sebald, W., Dreyer, M.K.
Deposit date:2000-04-07
Release date:2000-10-07
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structure of the BMP-2-BRIA ectodomain complex.
Nat.Struct.Biol., 7, 2000
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