5NGV

CRYSTAL STRUCTURE OF THE Activin receptor type-2B LIGAND BINDING DOMAIN IN COMPLEX WITH BIMAGRUMAB FV, ORTHORHOMBIC CRYSTAL FORM

Summary for 5NGV

• Entry DOI: 10.2210/pdb5ngv/pdb
• Descriptor: Activin receptor type-2B, anti-human ActRIIB mAb BYM338 heavy-chain, anti-human ActRIIB mAb BYM338 light-chain, ... (5 entities in total)
• Functional Keywords: three-finger toxin fold, antibody fv fragment, transferase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 37744.70

Authors

Rondeau, J.-M.,Lehmann, S. (deposition date: 2017-03-20, release date: 2017-11-15, Last modification date: 2024-01-17)

• Primary citation: Morvan, F.,Rondeau, J.-M.,Zou, C.,Minetti, G.,Scheufler, C.,Scharenberg, M.,Jacobi, C.,Brebbia, P.,Ritter, V.,Toussaint, G.,Koelbing, C.,Leber, X.,Schilb, A.,Witte, F.,Lehmann, S.,Koch, E.,Geisse, S.,Glass, D.J.,Lach-Trifilieff, E.; Blockade of activin type II receptors with a dual anti-ActRIIA/IIB antibody is critical to promote maximal skeletal muscle hypertrophy.; Proc. Natl. Acad. Sci. U.S.A., 114:12448-12453, 2017; PubMed: 29109273; DOI: 10.1073/pnas.1707925114

Experimental method

X-RAY DIFFRACTION (2 Å)