5NGV
CRYSTAL STRUCTURE OF THE Activin receptor type-2B LIGAND BINDING DOMAIN IN COMPLEX WITH BIMAGRUMAB FV, ORTHORHOMBIC CRYSTAL FORM
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Activin receptor type-2B | polymer | 99 | 11646.9 | 1 | UniProt (Q13705) Pfam (PF01064) | Homo sapiens (Human) | Activin receptor type IIB,ACTR-IIB |
| 2 | B (H) | anti-human ActRIIB mAb BYM338 heavy-chain | polymer | 121 | 13406.9 | 1 | Homo sapiens (Human) | ||
| 3 | C (L) | anti-human ActRIIB mAb BYM338 light-chain | polymer | 119 | 12496.7 | 1 | Homo sapiens (Human) | ||
| 4 | D (L) | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 1 | Chemie (PG4) | |||
| 5 | E, F, G (A, H, L) | water | water | 18.0 | 174 | Chemie (HOH) |
Sequence modifications
A: 24 - 117 (UniProt: Q13705)
| PDB | External Database | Details |
|---|---|---|
| Gly 19 | - | expression tag |
| Pro 20 | - | expression tag |
| Lys 21 | - | expression tag |
| Ala 22 | - | expression tag |
| Met 23 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 37550.5 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 194.2 | |
| All* | Total formula weight | 37744.7 |
