Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

5NHR

CRYSTAL STRUCTURE OF THE Activin receptor type-2B LIGAND BINDING DOMAIN IN COMPLEX WITH BIMAGRUMAB FV, CUBIC CRYSTAL FORM

Summary for 5NHR
Entry DOI10.2210/pdb5nhr/pdb
DescriptorBimagrumab Fv Light-Chain, Bimagrumab Fv heavy-chain, Activin receptor type-2B (3 entities in total)
Functional Keywordsthree-finger toxin fold, antibody fv fragment, immune system
Biological sourceHomo sapiens (Human)
More
Cellular locationCell membrane ; Single-pass type I membrane protein : Q13705
Total number of polymer chains6
Total formula weight75169.07
Authors
Rondeau, J.-M. (deposition date: 2017-03-22, release date: 2017-11-15, Last modification date: 2024-01-17)
Primary citationMorvan, F.,Rondeau, J.-M.,Zou, C.,Minetti, G.,Scheufler, C.,Scharenberg, M.,Jacobi, C.,Brebbia, P.,Ritter, V.,Toussaint, G.,Koelbing, C.,Leber, X.,Schilb, A.,Witte, F.,Lehmann, S.,Koch, E.,Geisse, S.,Glass, D.J.,Lach-Trifilieff, E.
Blockade of activin type II receptors with a dual anti-ActRIIA/IIB antibody is critical to promote maximal skeletal muscle hypertrophy.
Proc. Natl. Acad. Sci. U.S.A., 114:12448-12453, 2017
Cited by
PubMed: 29109273
DOI: 10.1073/pnas.1707925114
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.35 Å)
Structure validation

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon