5NH3

CRYSTAL STRUCTURE OF THE Activin receptor type-2A LIGAND BINDING DOMAIN IN COMPLEX WITH BIMAGRUMAB FV

Summary for 5NH3

Entry DOI	10.2210/pdb5nh3/pdb
Descriptor	Activin receptor type-2A, anti-human ActRIIB mAb BYM338 Fv heavy-chain, anti-human ActRIIB mAb BYM338 Fv light-chain, ... (6 entities in total)
Functional Keywords	other, epitope mapping, transferase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	6
Total formula weight	81322.89
Authors	Scheufler, C. (deposition date: 2017-03-21, release date: 2017-11-15, Last modification date: 2024-01-17)
Primary citation	Morvan, F.,Rondeau, J.M.,Zou, C.,Minetti, G.,Scheufler, C.,Scharenberg, M.,Jacobi, C.,Brebbia, P.,Ritter, V.,Toussaint, G.,Koelbing, C.,Leber, X.,Schilb, A.,Witte, F.,Lehmann, S.,Koch, E.,Geisse, S.,Glass, D.J.,Lach-Trifilieff, E. Blockade of activin type II receptors with a dual anti-ActRIIA/IIB antibody is critical to promote maximal skeletal muscle hypertrophy. Proc. Natl. Acad. Sci. U.S.A., 114:12448-12453, 2017 Cited by PubMed: 29109273 DOI: 10.1073/pnas.1707925114 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.35 Å)

Structure validation