5NH3
CRYSTAL STRUCTURE OF THE Activin receptor type-2A LIGAND BINDING DOMAIN IN COMPLEX WITH BIMAGRUMAB FV
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Activin receptor type-2A | polymer | 122 | 14196.8 | 2 | UniProt (P27037) Pfam (PF01064) | Homo sapiens (Human) | Activin receptor type IIA,ACTRIIA |
| 2 | C, D (H, I) | anti-human ActRIIB mAb BYM338 Fv heavy-chain | polymer | 121 | 13406.9 | 2 | Homo sapiens (Human) | MOR08159_germlined Fv | |
| 3 | E, F (L, M) | anti-human ActRIIB mAb BYM338 Fv light-chain | polymer | 119 | 12513.7 | 2 | Homo sapiens (Human) | MOR08159_germlined Fv | |
| 4 | G (C) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 5 | H, I, J (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) | |||
| 6 | K, L, M, N, O... (A, B, H, I, L...) | water | water | 18.0 | 361 | Chemie (HOH) |
Sequence modifications
A, B: 20 - 135 (UniProt: P27037)
| PDB | External Database | Details |
|---|---|---|
| Glu 136 | - | expression tag |
| Phe 137 | - | expression tag |
| Arg 138 | - | expression tag |
| His 139 | - | expression tag |
| Asp 140 | - | expression tag |
| Ser 141 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 80234.9 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 424.4 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 663.6 | |
| All* | Total formula weight | 81322.9 |
