5O32
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THE STRUCTURE OF COMPLEMENT COMPLEX
Descriptor:Complement C3, Complement factor H,Complement factor H, Complement factor I, ...
Authors:Xue, X., Wu, J., Forneris, F., Gros, P.
Deposit date:2017-05-23
Release date:2017-06-28
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (4.206209 Å)
Cite:Regulator-dependent mechanisms of C3b processing by factor I allow differentiation of immune responses.
Nat. Struct. Mol. Biol., 24, 2017
5O35
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STRUCTURE OF COMPLEMENT PROTEINS COMPLEX
Descriptor:Complement C3, Complement factor H,Complement factor H, N-ACETYL-D-GLUCOSAMINE
Authors:Xue, X., Wu, J., Forneris, F., Gros, P.
Deposit date:2017-05-23
Release date:2017-06-28
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (4.2 Å)
Cite:Regulator-dependent mechanisms of C3b processing by factor I allow differentiation of immune responses.
Nat. Struct. Mol. Biol., 24, 2017
5NBQ
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THE STRUCTURE OF THE TRIPARTITE COMPLEX BETWEEN OSPE, THE C-TERMINAL DOMAINS OF FACTOR H AND C3DG
Descriptor:Complement C3, Complement factor H, Outer surface protein E, ...
Authors:Kolodziejczyk, R., Mikula, K.M., Kotila, T.M., Postis, V.L.G., Sakari, J.T., Meri, T.
Deposit date:2017-03-02
Release date:2017-12-06
Last modified:2017-12-13
Method:X-RAY DIFFRACTION (3.18 Å)
Cite:Crystal structure of a tripartite complex between C3dg, C-terminal domains of factor H and OspE of Borrelia burgdorferi.
PLoS ONE, 12, 2017
5UBM
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CRYSTAL STRUCTURE OF HUMAN C1S IN COMPLEX WITH INHIBITOR GIGASTASIN
Descriptor:Complement C1s subcomponent, Gigastasin, N-ACETYL-D-GLUCOSAMINE
Authors:Pang, S.S., Whisstock, J.C.
Deposit date:2016-12-20
Release date:2017-11-08
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The Structural Basis for Complement Inhibition by Gigastasin, a Protease Inhibitor from the Giant Amazon Leech.
J. Immunol., 199, 2017
5JPM
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STRUCTURE OF THE COMPLEX OF HUMAN COMPLEMENT C4 WITH MASP-2 REBUILT USING IMDFF
Descriptor:Complement C4-A, Mannan-binding lectin serine protease 2, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Croll, T.I., Andersen, G.R.
Deposit date:2016-05-03
Release date:2016-08-10
Last modified:2016-09-28
Method:X-RAY DIFFRACTION (3.75 Å)
Cite:Re-evaluation of low-resolution crystal structures via interactive molecular-dynamics flexible fitting (iMDFF): a case study in complement C4.
Acta Crystallogr D Struct Biol, 72, 2016
5I0Q
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STRUCTURE OF HUMAN C4B-BINDING PROTEIN ALPHA CHAIN CCP DOMAINS 1 AND 2 IN COMPLEX WITH THE HYPERVARIABLE REGION OF MUTANT GROUP A STREPTOCOCCUS M2 (K65A, N66A) PROTEIN
Descriptor:M protein, serotype 2.1, C4b-binding protein alpha chain
Authors:Buffalo, C.Z., Bahn-Suh, A.J., Ghosh, P.
Deposit date:2016-02-04
Release date:2016-07-20
Last modified:2016-10-26
Method:X-RAY DIFFRACTION (2.293 Å)
Cite:Conserved patterns hidden within group A Streptococcus M protein hypervariability recognize human C4b-binding protein.
Nat Microbiol, 1, 2016
5HZP
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STRUCTURE OF HUMAN C4B-BINDING PROTEIN ALPHA CHAIN CCP DOMAINS 1 AND 2 IN COMPLEX WITH THE HYPERVARIABLE REGION OF GROUP A STREPTOCOCCUS M49 PROTEIN.
Descriptor:M protein, serotype 49, C4b-binding protein alpha chain, ...
Authors:Buffalo, C.Z., Bahn-Suh, A.J., Ghosh, P.
Deposit date:2016-02-02
Release date:2016-07-20
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.74 Å)
Cite:Conserved patterns hidden within group A Streptococcus M protein hypervariability recognize human C4b-binding protein.
Nat Microbiol, 1, 2016
5HYP
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STRUCTURE OF HUMAN C4B-BINDING PROTEIN ALPHA CAIN CCP DOMAINS 1 AND 2 IN COMPLEX WITH THE HYPERVARIABLE REGION OF GROUP A STREPTOCOCCUS M28 PROTEIN
Descriptor:C4b-binding protein alpha chain, M28 protein
Authors:Buffalo, C.Z., Bahn-Suh, A.J., Ghosh, P.
Deposit date:2016-02-01
Release date:2016-07-20
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (3.024 Å)
Cite:Conserved patterns hidden within group A Streptococcus M protein hypervariability recognize human C4b-binding protein.
Nat Microbiol, 1, 2016
5HYT
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STRUCTURE OF HUMAN C4B-BINIDNG PROTEIN ALPHA CHAIN CCP DOMAINS 1 AND 2 IN COMPLEX WITH THE HYPERVARIABLE REGION OF GROUP A STREPTOCOCCUS M22 PROTEIN
Descriptor:Precursor to Protein Sir22, C4b-binding protein alpha chain
Authors:Buffalo, C.Z., Bahn-Suh, A.J., Ghosh, P.
Deposit date:2016-02-01
Release date:2016-07-20
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.54 Å)
Cite:Conserved patterns hidden within group A Streptococcus M protein hypervariability recognize human C4b-binding protein.
Nat Microbiol, 1, 2016
5HYU
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STRUCTURE OF HUMAN C4B-BINDING PROTEIN ALPHA CHAIN CCP DOMAINS 1 AND 2 IN COMPLEX WITH THE HYPERVARIABLE REGION OF GROUP A STREPTOCOCCUS M2 PROTEIN
Descriptor:M protein, serotype 2.1, C4b-binding protein alpha chain
Authors:Buffalo, C.Z., Bahn-Suh, A.J., Ghosh, P.
Deposit date:2016-02-01
Release date:2016-07-20
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.561 Å)
Cite:Conserved patterns hidden within group A Streptococcus M protein hypervariability recognize human C4b-binding protein.
Nat Microbiol, 1, 2016
5FO8
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CRYSTAL STRUCTURE OF HUMAN COMPLEMENT C3B IN COMPLEX WITH MCP (CCP1-4)
Descriptor:COMPLEMENT C3, MEMBRANE COFACTOR PROTEIN, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Forneris, F., Wu, J., Xue, X., Gros, P.
Deposit date:2015-11-18
Release date:2016-04-06
Last modified:2016-06-01
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Regulators of Complement Activity Mediate Inhibitory Mechanisms Through a Common C3B-Binding Mode.
Embo J., 35, 2016
5FO9
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CRYSTAL STRUCTURE OF HUMAN COMPLEMENT C3B IN COMPLEX WITH CR1 (CCP15- 17)
Descriptor:COMPLEMENT C3 BETA CHAIN, COMPLEMENT C3B ALPHA' CHAIN, COMPLEMENT RECEPTOR TYPE 1, ...
Authors:Forneris, F., Wu, J., Xue, X., Gros, P.
Deposit date:2015-11-18
Release date:2016-04-06
Last modified:2016-06-01
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Regulators of Complement Activity Mediate Inhibitory Mechanisms Through a Common C3B-Binding Mode.
Embo J., 35, 2016
5FOA
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CRYSTAL STRUCTURE OF HUMAN COMPLEMENT C3B IN COMPLEX WITH DAF (CCP2-4)
Descriptor:COMPLEMENT C3 BETA CHAIN, COMPLEMENT C3B ALPHA CHAIN, DECAY ACCELERATING FACTOR, ...
Authors:Forneris, F., Wu, J., Xue, X., Gros, P.
Deposit date:2015-11-18
Release date:2016-04-06
Last modified:2016-06-01
Method:X-RAY DIFFRACTION (4.188 Å)
Cite:Regulators of Complement Activity Mediate Inhibitory Mechanisms Through a Common C3B-Binding Mode.
Embo J., 35, 2016
5FOB
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CRYSTAL STRUCTURE OF HUMAN COMPLEMENT C3B IN COMPLEX WITH SMALLPOX INHIBITOR OF COMPLEMENT (SPICE)
Descriptor:COMPLEMENT C3 BETA CHAIN, COMPLEMENT C3B ALPHA' CHAIN, SMALLPOX INHIBITOR OF COMPLEMENT SPICE, ...
Authors:Forneris, F., Wu, J., Xue, X., Gros, P.
Deposit date:2015-11-18
Release date:2016-04-06
Last modified:2016-06-01
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Regulators of Complement Activity Mediate Inhibitory Mechanisms Through a Common C3B-Binding Mode.
Embo J., 35, 2016
4ZH1
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COMPLEMENT FACTOR H IN COMPLEX WITH THE GM1 GLYCAN
Descriptor:Complement C3, Complement factor H, GLYCEROL, ...
Authors:Blaum, B.S., Stehle, T.
Deposit date:2015-04-24
Release date:2016-01-13
Last modified:2016-04-13
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:Complement Factor H and Simian Virus 40 bind the GM1 ganglioside in distinct conformations.
Glycobiology, 26, 2016
4CSY
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E-SELECTIN LECTIN, EGF-LIKE AND TWO SCR DOMAINS COMPLEXED WITH SIALYL LEWIS X
Descriptor:E-SELECTIN, N-ACETYL-D-GLUCOSAMINE, O-SIALIC ACID, ...
Authors:Preston, R.C., Jakob, R.P., Binder, F.P.C., Sager, C.P., Ernst, B., Maier, T.
Deposit date:2014-03-11
Release date:2014-09-24
Last modified:2016-01-27
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:E-Selectin Ligand Complexes Adopt an Extended High-Affinity Conformation.
J.Mol.Cell.Biol., 8, 2016
4ONT
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TERNARY HOST RECOGNITION COMPLEX OF COMPLEMENT FACTOR H, C3D, AND SIALIC ACID
Descriptor:Complement factor H, Complement C3d fragment, O-SIALIC ACID, ...
Authors:Blaum, B.S., Stehle, T.S.
Deposit date:2014-01-29
Release date:2014-11-26
Last modified:2015-01-14
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structural basis for sialic acid-mediated self-recognition by complement factor H.
Nat.Chem.Biol., 11, 2015
4MUC
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THE 4TH AND 5TH C-TERMINAL DOMAINS OF FACTOR H RELATED PROTEIN 1
Descriptor:Complement factor H-related protein 1, SULFATE ION
Authors:Bhattacharjee, A., Goldman, A., Kolodziejczyk, R., Jokiranta, T.S.
Deposit date:2013-09-21
Release date:2015-02-18
Last modified:2015-05-06
Method:X-RAY DIFFRACTION (2.897 Å)
Cite:The Major Autoantibody Epitope on Factor H in Atypical Hemolytic Uremic Syndrome Is Structurally Different from Its Homologous Site in Factor H-related Protein 1, Supporting a Novel Model for Induction of Autoimmunity in This Disease.
J.Biol.Chem., 290, 2015
2MCY
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CR1 SUSHI DOMAINS 2 AND 3
Descriptor:Complement receptor type 1
Authors:Park, H.J., Guariento, M.J., Maciejewski, M., Hauart, R., Tham, W., Cowman, A.F., Schmidt, C.Q., Martens, H., Liszewski, K.M., Hourcade, D., Barlow, P.N., Atkinson, J.P.
Deposit date:2013-08-27
Release date:2013-11-13
Last modified:2014-01-22
Method:SOLUTION NMR
Cite:Using Mutagenesis and Structural Biology to Map the Binding Site for the Plasmodium falciparum Merozoite Protein PfRh4 on the Human Immune Adherence Receptor.
J.Biol.Chem., 289, 2014
2MCZ
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CR1 SUSHI DOMAINS 1 AND 2
Descriptor:Complement receptor type 1
Authors:Park, H.J., Guariento, M.J., Maciejewski, M., Hauart, R., Tham, W., Cowman, A.F., Schmidt, C.Q., Martens, H., Liszewski, K.M., Hourcade, D., Barlow, P.N., Atkinson, J.P.
Deposit date:2013-08-27
Release date:2013-11-13
Last modified:2014-01-22
Method:SOLUTION NMR
Cite:Using Mutagenesis and Structural Biology to Map the Binding Site for the Plasmodium falciparum Merozoite Protein PfRh4 on the Human Immune Adherence Receptor.
J.Biol.Chem., 289, 2014
4C16
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E-SELECTIN LECTIN, EGF-LIKE AND TWO SCR DOMAINS COMPLEXED WITH GLYCOMIMETIC ANTAGONIST
Descriptor:E-SELECTIN, N-ACETYL-D-GLUCOSAMINE, CALCIUM ION, ...
Authors:Preston, R.C., Jakob, R.P., Binder, F.P.C., Sager, C.P., Ernst, B., Maier, T.
Deposit date:2013-08-09
Release date:2014-08-20
Last modified:2016-01-27
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:E-Selectin Ligand Complexes Adopt an Extended High-Affinity Conformation.
J.Mol.Cell.Biol., 8, 2016
4LOS
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C1S CUB2-CCP1
Descriptor:Complement C1s subcomponent heavy chain, CALCIUM ION
Authors:Wallis, R., Venkatraman Girija, U., Moody, P.C.E., Marshall, J.E., Gingras, A.R.
Deposit date:2013-07-13
Release date:2013-08-07
Last modified:2013-09-04
Method:X-RAY DIFFRACTION (1.996 Å)
Cite:Structural basis of the C1q/C1s interaction and its central role in assembly of the C1 complex of complement activation.
Proc.Natl.Acad.Sci.USA, 110, 2013
4LOT
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C1S CUB2-CCP1-CCP2
Descriptor:Complement C1s subcomponent heavy chain
Authors:Wallis, R., Venkatraman Girija, U., Moody, P.C.E., Marshall, J.E.
Deposit date:2013-07-13
Release date:2013-08-07
Last modified:2013-09-04
Method:X-RAY DIFFRACTION (2.92 Å)
Cite:Structural basis of the C1q/C1s interaction and its central role in assembly of the C1 complex of complement activation.
Proc.Natl.Acad.Sci.USA, 110, 2013
4KKD
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THE X-RAY CRYSTAL STRUCTURE OF MANNOSE-BINDING LECTIN-ASSOCIATED SERINE PROTEINASE-3 REVEALS THE STRUCTURAL BASIS FOR ENZYME INACTIVITY ASSOCIATED WITH THE 3MC SYNDROME
Descriptor:Mannan-binding lectin serine protease 1, IMIDAZOLE
Authors:Yongqing, T., Wilmann, P.G., Reeve, S.B., Coetzer, T.H., Smith, A.I., Whisstock, J.C., Pike, R.N., Wijeyewickrema, L.C.
Deposit date:2013-05-05
Release date:2013-07-03
Last modified:2013-08-21
Method:X-RAY DIFFRACTION (2.5991 Å)
Cite:The X-ray Crystal Structure of Mannose-binding Lectin-associated Serine Proteinase-3 Reveals the Structural Basis for Enzyme Inactivity Associated with the Carnevale, Mingarelli, Malpuech, and Michels (3MC) Syndrome.
J.Biol.Chem., 288, 2013
4K12
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STRUCTURAL BASIS FOR HOST SPECIFICITY OF FACTOR H BINDING BY STREPTOCOCCUS PNEUMONIAE
Descriptor:Complement factor H, Choline binding protein A
Authors:Liu, A., Achila, D., Banerjee, R., Martinez-Hackert, E., Li, Y., Yan, H.
Deposit date:2013-04-04
Release date:2014-04-09
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.079 Å)
Cite:Structural determinants of host specificity of complement Factor H recruitment by Streptococcus pneumoniae.
Biochem.J., 465, 2015
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