8ACF

Structure of the argX-117 in complex with a complement C2 fragment at low pH

Summary for 8ACF

• Entry DOI: 10.2210/pdb8acf/pdb
• Descriptor: Complement C2b fragment, Heavy chain of mAb ARGX-117 Fab, Nanobody specific for the kappa-light chain, ... (9 entities in total)
• Functional Keywords: innate immune system, complement, antibody, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 83939.91

Authors

Olesen, H.G.,Andersen, G.R. (deposition date: 2022-07-05, release date: 2024-01-17)

• Primary citation: Olesen, H.G.,Andersen, G.R.; Structure-function analysis of ARGX-117, a calcium- and pH-dependent clinical phase complement C2 blocking antibody; To be published,

Experimental method

X-RAY DIFFRACTION (1.8 Å)