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8YZK
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BU of 8yzk by Molmil
Orphan receptor GPRC5D in complex with scFv150-18
Descriptor: Soluble cytochrome b562,G-protein coupled receptor family C group 5 member D, scFv
Authors:Yan, P, Lin, X, Xu, F.
Deposit date:2024-04-07
Release date:2024-07-03
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:The binding mechanism of an anti-multiple myeloma antibody to the human GPRC5D homodimer.
Nat Commun, 15, 2024
9AYF
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BU of 9ayf by Molmil
Structure of human calcium-sensing receptor in complex with Gi1 (miniGi1) protein in detergent
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3-(2-chlorophenyl)-N-[(1R)-1-(3-methoxyphenyl)ethyl]propan-1-amine, ...
Authors:Zuo, H, Park, J, Frangaj, A, Ye, J, Lu, G, Manning, J.J, Asher, W.B, Lu, Z, Hu, G, Wang, L, Mendez, J, Eng, E, Zhang, Z, Lin, X, Grasucci, R, Hendrickson, W.A, Clarke, O.B, Javitch, J.A, Conigrave, A.D, Fan, Q.R.
Deposit date:2024-03-07
Release date:2024-04-17
Last modified:2024-05-22
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Promiscuous G-protein activation by the calcium-sensing receptor.
Nature, 629, 2024
9AXF
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BU of 9axf by Molmil
Structure of human calcium-sensing receptor in complex with chimeric Gq (miniGisq) protein in detergent
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3-(2-chlorophenyl)-N-[(1R)-1-(3-methoxyphenyl)ethyl]propan-1-amine, ...
Authors:Zuo, H, Park, J, Frangaj, A, Ye, J, Lu, G, Manning, J.J, Asher, W.B, Lu, Z, Hu, G, Wang, L, Mendez, J, Eng, E, Zhang, Z, Lin, X, Grasucci, R, Hendrickson, W.A, Clarke, O.B, Javitch, J.A, Conigrave, A.D, Fan, Q.R.
Deposit date:2024-03-06
Release date:2024-04-17
Last modified:2024-05-22
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Promiscuous G-protein activation by the calcium-sensing receptor.
Nature, 629, 2024
9AVL
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BU of 9avl by Molmil
Structure of human calcium-sensing receptor in complex with Gi3 protein in nanodiscs
Descriptor: (19R,22S,25R)-22,25,26-trihydroxy-16,22-dioxo-17,21,23-trioxa-22lambda~5~-phosphahexacosan-19-yl (9Z)-octadec-9-enoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Zuo, H, Park, J, Frangaj, A, Ye, J, Lu, G, Manning, J.J, Asher, W.B, Lu, Z, Hu, G, Wang, L, Mendez, J, Eng, E, Zhang, Z, Lin, X, Grasucci, R, Hendrickson, W.A, Clarke, O.B, Javitch, J.A, Conigrave, A.D, Fan, Q.R.
Deposit date:2024-03-04
Release date:2024-04-17
Last modified:2024-05-22
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Promiscuous G-protein activation by the calcium-sensing receptor.
Nature, 629, 2024
9AVG
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BU of 9avg by Molmil
Structure of human calcium-sensing receptor in complex with chimeric Gs (miniGis) protein in nanodiscs
Descriptor: (19R,22S,25R)-22,25,26-trihydroxy-16,22-dioxo-17,21,23-trioxa-22lambda~5~-phosphahexacosan-19-yl (9Z)-octadec-9-enoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Zuo, H, Park, J, Frangaj, A, Ye, J, Lu, G, Manning, J.J, Asher, W.B, Lu, Z, Hu, G, Wang, L, Mendez, J, Eng, E, Zhang, Z, Lin, X, Grasucci, R, Hendrickson, W.A, Clarke, O.B, Javitch, J.A, Conigrave, A.D, Fan, Q.R.
Deposit date:2024-03-02
Release date:2024-04-17
Last modified:2024-05-22
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Promiscuous G-protein activation by the calcium-sensing receptor.
Nature, 629, 2024
9ASB
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BU of 9asb by Molmil
Structure of human calcium-sensing receptor in complex with chimeric Gq (miniGisq) protein in nanodiscs
Descriptor: (19R,22S,25R)-22,25,26-trihydroxy-16,22-dioxo-17,21,23-trioxa-22lambda~5~-phosphahexacosan-19-yl (9Z)-octadec-9-enoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Zuo, H, Park, J, Frangaj, A, Ye, J, Lu, G, Manning, J.J, Asher, W.B, Lu, Z, Hu, G, Wang, L, Mendez, J, Eng, E, Zhang, Z, Lin, X, Grasucci, R, Hendrickson, W.A, Clarke, O.B, Javitch, J.A, Conigrave, A.D, Fan, Q.R.
Deposit date:2024-02-24
Release date:2024-04-17
Last modified:2024-05-22
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Promiscuous G-protein activation by the calcium-sensing receptor.
Nature, 629, 2024
8WPU
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BU of 8wpu by Molmil
Human calcium-sensing receptor(CaSR) bound to cinacalcet in complex with Gq protein
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Ling, S.L, Meng, X.Y, Tian, C.L.
Deposit date:2023-10-10
Release date:2023-11-22
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural insights into asymmetric activation of the calcium-sensing receptor-G q complex.
Cell Res., 34, 2024
8WPG
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BU of 8wpg by Molmil
Human calcium-sensing receptor bound with cinacalcet in detergent
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Ling, S.L, Meng, X.Y, Tian, C.L.
Deposit date:2023-10-10
Release date:2023-11-22
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Structural insights into asymmetric activation of the calcium-sensing receptor-G q complex.
Cell Res., 34, 2024
8TRD
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BU of 8trd by Molmil
mGluR3 class 1 in the presence of the antagonist LY 341495
Descriptor: 2-[(1S,2S)-2-carboxycyclopropyl]-3-(9H-xanthen-9-yl)-D-alanine, Metabotropic glutamate receptor 3
Authors:Strauss, A, Levitz, J.
Deposit date:2023-08-09
Release date:2024-07-31
Last modified:2024-08-14
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structural basis of positive allosteric modulation of metabotropic glutamate receptor activation and internalization.
Nat Commun, 15, 2024
8TRC
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BU of 8trc by Molmil
mGluR3 in the presence of the antagonist LY 341495 and positive allosteric modulator VU6023326
Descriptor: 2-[(1S,2S)-2-carboxycyclopropyl]-3-(9H-xanthen-9-yl)-D-alanine, Metabotropic glutamate receptor 3
Authors:Strauss, A, Levitz, J.
Deposit date:2023-08-09
Release date:2024-07-31
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structural basis of allosteric modulation of metabotropic glutamate receptor activation and desensitization.
Biorxiv, 2023
8TR2
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BU of 8tr2 by Molmil
mGluR3 in the presence of the agonist LY379268
Descriptor: (1S,4R,5R,6S)-4-amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid, CALCIUM ION, Metabotropic glutamate receptor 3
Authors:Strauss, A, Levitz, J.
Deposit date:2023-08-09
Release date:2024-07-31
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structural basis of allosteric modulation of metabotropic glutamate receptor activation and desensitization.
Biorxiv, 2023
8TR0
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BU of 8tr0 by Molmil
Metabotropic glutamate receptor 3 class 3 bound to antagonist LY 341495
Descriptor: 2-[(1S,2S)-2-carboxycyclopropyl]-3-(9H-xanthen-9-yl)-D-alanine, Metabotropic glutamate receptor 3
Authors:Strauss, A, Levitz, J.
Deposit date:2023-08-09
Release date:2024-07-31
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structural basis of allosteric modulation of metabotropic glutamate receptor activation and desensitization.
Biorxiv, 2023
8TQB
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BU of 8tqb by Molmil
mGluR3 in the presence of the agonist LY379268 and PAM VU6023326
Descriptor: (1R,4R,5S,6R)-4-azanyl-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid, CALCIUM ION, Metabotropic glutamate receptor 3
Authors:Strauss, A, Levitz, J.
Deposit date:2023-08-06
Release date:2024-07-31
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structural basis of allosteric modulation of metabotropic glutamate receptor activation and desensitization.
Biorxiv, 2023
8TAO
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BU of 8tao by Molmil
Quis and CDPPB bound active mGlu5
Descriptor: (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID, 3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide, Metabotropic glutamate receptor 5, ...
Authors:Krishna Kumar, K, Wang, H, Kobilka, B.K.
Deposit date:2023-06-27
Release date:2023-10-11
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Stepwise activation of a metabotropic glutamate receptor.
Nature, 629, 2024
8T8M
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BU of 8t8m by Molmil
Quis-bound intermediate mGlu5
Descriptor: (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID, Metabotropic glutamate receptor 5, Nb43
Authors:Krishna Kumar, K, Wang, H, Kobilka, B.K.
Deposit date:2023-06-22
Release date:2023-10-11
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Stepwise activation of a metabotropic glutamate receptor.
Nature, 629, 2024
8T7H
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BU of 8t7h by Molmil
Quis-bound intermediate mGlu5
Descriptor: (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID, Metabotropic glutamate receptor 5, Nanobody 43
Authors:Krishna Kumar, K, Wang, H, Kobilka, B.K.
Deposit date:2023-06-20
Release date:2023-10-11
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Stepwise activation of a metabotropic glutamate receptor.
Nature, 629, 2024
8T6J
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BU of 8t6j by Molmil
CDPPB-bound inactive mGlu5
Descriptor: 3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide, Metabotropic glutamate receptor 5
Authors:Krishna Kumar, K, Wang, H, Kobilka, B.K.
Deposit date:2023-06-16
Release date:2023-10-11
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Stepwise activation of a metabotropic glutamate receptor.
Nature, 629, 2024
8SZI
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BU of 8szi by Molmil
Cryo-EM structure of PAM-free human calcium-sensing receptor CaSR-Gi complex in lipid nanodiscs
Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:He, F, Wu, C, Gao, Y, Skiniotis, G.
Deposit date:2023-05-29
Release date:2024-02-07
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Allosteric modulation and G-protein selectivity of the Ca 2+ -sensing receptor.
Nature, 626, 2024
8SZF
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BU of 8szf by Molmil
Cryo-EM structure of cinacalcet-bound active-state human calcium-sensing receptor CaSR in lipid nanodiscs
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:He, F, Wu, C, Gao, Y, Skiniotis, G.
Deposit date:2023-05-29
Release date:2024-02-07
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Allosteric modulation and G-protein selectivity of the Ca 2+ -sensing receptor.
Nature, 626, 2024
8SZG
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BU of 8szg by Molmil
Cryo-EM structure of cinacalcet-bound human calcium-sensing receptor CaSR-Gq complex in lipid nanodiscs
Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:He, F, Wu, C, Gao, Y, Skiniotis, G.
Deposit date:2023-05-29
Release date:2024-02-07
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Allosteric modulation and G-protein selectivity of the Ca 2+ -sensing receptor.
Nature, 626, 2024
8SZH
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BU of 8szh by Molmil
Cryo-EM structure of cinacalcet-bound human calcium-sensing receptor CaSR-Gi complex in lipid nanodiscs
Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:He, F, Wu, C, Gao, Y, Skiniotis, G.
Deposit date:2023-05-29
Release date:2024-02-07
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Allosteric modulation and G-protein selectivity of the Ca 2+ -sensing receptor.
Nature, 626, 2024
8JD1
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BU of 8jd1 by Molmil
Cryo-EM structure of mGlu2-mGlu3 heterodimer in Rco state
Descriptor: CHOLESTEROL, GLUTAMIC ACID, Metabotropic glutamate receptor 2,Peptidyl-prolyl cis-trans isomerase FKBP1A, ...
Authors:Wang, X, Wang, M, Xu, T, Feng, Y, Han, S, Lin, S, Zhao, Q, Wu, B.
Deposit date:2023-05-12
Release date:2023-06-21
Last modified:2023-10-18
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Structural insights into dimerization and activation of the mGlu2-mGlu3 and mGlu2-mGlu4 heterodimers.
Cell Res., 33, 2023
8JCW
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BU of 8jcw by Molmil
Cryo-EM structure of mGlu2-mGlu3 heterodimer in presence of LY341495 and NAM563 (dimerization mode I)
Descriptor: 2-[(1S,2S)-2-carboxycyclopropyl]-3-(9H-xanthen-9-yl)-D-alanine, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ...
Authors:Wang, X, Wang, M, Xu, T, Feng, Y, Han, S, Lin, S, Zhao, Q, Wu, B.
Deposit date:2023-05-12
Release date:2023-06-21
Last modified:2023-10-18
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural insights into dimerization and activation of the mGlu2-mGlu3 and mGlu2-mGlu4 heterodimers.
Cell Res., 33, 2023
8JD2
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BU of 8jd2 by Molmil
Cryo-EM structure of G protein-free mGlu2-mGlu3 heterodimer in Acc state
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, GLUTAMIC ACID, Metabotropic glutamate receptor 2,Peptidyl-prolyl cis-trans isomerase FKBP1A, ...
Authors:Wang, X, Wang, M, Xu, T, Feng, Y, Han, S, Lin, S, Zhao, Q, Wu, B.
Deposit date:2023-05-12
Release date:2023-06-21
Last modified:2023-10-18
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Structural insights into dimerization and activation of the mGlu2-mGlu3 and mGlu2-mGlu4 heterodimers.
Cell Res., 33, 2023
8JCV
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BU of 8jcv by Molmil
Cryo-EM structure of mGlu2-mGlu3 heterodimer in presence of LY341495 (dimerization mode II)
Descriptor: 2-[(1S,2S)-2-carboxycyclopropyl]-3-(9H-xanthen-9-yl)-D-alanine, 2-acetamido-2-deoxy-beta-D-glucopyranose, Metabotropic glutamate receptor 2,Peptidyl-prolyl cis-trans isomerase FKBP1A, ...
Authors:Wang, X, Wang, M, Xu, T, Feng, Y, Han, S, Zhao, Q, Wu, B.
Deposit date:2023-05-12
Release date:2023-06-21
Last modified:2023-10-18
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structural insights into dimerization and activation of the mGlu2-mGlu3 and mGlu2-mGlu4 heterodimers.
Cell Res., 33, 2023

 

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