8T7H

Quis-bound intermediate mGlu5

Summary for 8T7H

• Entry DOI: 10.2210/pdb8t7h/pdb
• EMDB information: 41092 41807 41808
• Descriptor: Metabotropic glutamate receptor 5, Nanobody 43, (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID (3 entities in total)
• Functional Keywords: gpcr, signaling protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 224824.19

Authors

Krishna Kumar, K.,Wang, H.,Kobilka, B.K. (deposition date: 2023-06-20, release date: 2023-10-11, Last modification date: 2024-06-05)

• Primary citation: Krishna Kumar, K.,Wang, H.,Habrian, C.,Latorraca, N.R.,Xu, J.,O'Brien, E.S.,Zhang, C.,Montabana, E.,Koehl, A.,Marqusee, S.,Isacoff, E.Y.,Kobilka, B.K.; Stepwise activation of a metabotropic glutamate receptor.; Nature, 629:951-956, 2024; PubMed: 38632403; DOI: 10.1038/s41586-024-07327-x

Experimental method

ELECTRON MICROSCOPY (3.3 Å)