8SZF

Cryo-EM structure of cinacalcet-bound active-state human calcium-sensing receptor CaSR in lipid nanodiscs

Summary for 8SZF

• Entry DOI: 10.2210/pdb8szf/pdb
• EMDB information: 40914
• Descriptor: Extracellular calcium-sensing receptor, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
• Functional Keywords: family c gpcr, calcium-sensing receptor (casr), lipid nanodiscs, positive allosteric modulator, membrane protein, signaling protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 235899.14

Authors

He, F.,Wu, C.,Gao, Y.,Skiniotis, G. (deposition date: 2023-05-29, release date: 2024-02-07, Last modification date: 2024-03-13)

• Primary citation: He, F.,Wu, C.G.,Gao, Y.,Rahman, S.N.,Zaoralova, M.,Papasergi-Scott, M.M.,Gu, T.J.,Robertson, M.J.,Seven, A.B.,Li, L.,Mathiesen, J.M.,Skiniotis, G.; Allosteric modulation and G-protein selectivity of the Ca 2+ -sensing receptor.; Nature, 626:1141-1148, 2024; PubMed: 38326620; DOI: 10.1038/s41586-024-07055-2

Experimental method

ELECTRON MICROSCOPY (2.8 Å)