Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8SZF

Cryo-EM structure of cinacalcet-bound active-state human calcium-sensing receptor CaSR in lipid nanodiscs

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Extracellular calcium-sensing receptor	polymer	1101	123821.0	1	UniProt (P41180) Pfam (PF01094) Pfam (PF07562) Pfam (PF00003) In PDB	Homo sapiens (human)	CaR,CaSR,hCasR,Parathyroid cell calcium-sensing receptor 1,PCaR1
2	B	Extracellular calcium-sensing receptor	polymer	959	108023.1	1	UniProt (P41180) Pfam (PF01094) Pfam (PF07562) Pfam (PF00003) In PDB	Homo sapiens (human)	CaR,CaSR,hCasR,Parathyroid cell calcium-sensing receptor 1,PCaR1
3	C, D, E	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	3	In PDB GlyTouCan (G42666HT)
4	A, B	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	5	Chemie (NAG)
5	A, B	TRYPTOPHAN	non-polymer		204.2	2	Chemie (TRP)
6	A, B	CALCIUM ION	non-polymer		40.1	4	Chemie (CA)
7	A, B	PHOSPHATE ION	non-polymer		95.0	2	Chemie (PO4)
8	A, B	N-[(1R)-1-(naphthalen-1-yl)ethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine	non-polymer		357.4	2	Chemie (YP4)
9	B	SPERMINE	non-polymer		202.3	1	Chemie (SPM)

Sequence modifications

A: 19 - 894 (UniProt: P41180)

PDB	External Database	Details
Asp 9	-	expression tag
Tyr 10	-	expression tag
Lys 11	-	expression tag
Asp 12	-	expression tag
Asp 13	-	expression tag
Asp 14	-	expression tag
Asp 15	-	expression tag
Lys 16	-	expression tag
Ala 17	-	expression tag
Ala 18	-	expression tag
Thr 895	-	expression tag
Ser 896	-	expression tag
Thr 897	-	expression tag
Ser 898	-	expression tag
Val 899	-	expression tag
Thr 900	-	expression tag
Ser 901	-	expression tag
Val 902	-	expression tag
Asn 903	-	expression tag
Gln 904	-	expression tag
Ala 905	-	expression tag
Ser 906	-	expression tag
Thr 907	-	expression tag
Ser 908	-	expression tag
Arg 909	-	expression tag
Leu 910	-	expression tag
Glu 911	-	expression tag
Gly 912	-	expression tag
Leu 913	-	expression tag
Gln 914	-	expression tag
Ser 915	-	expression tag
Glu 916	-	expression tag
Asn 917	-	expression tag
His 918	-	expression tag
Arg 919	-	expression tag
Leu 920	-	expression tag
Arg 921	-	expression tag
Met 922	-	expression tag
Lys 923	-	expression tag
Ile 924	-	expression tag
Thr 925	-	expression tag
Glu 926	-	expression tag
Leu 927	-	expression tag
Asp 928	-	expression tag
Lys 929	-	expression tag
Asp 930	-	expression tag
Leu 931	-	expression tag
Glu 932	-	expression tag
Glu 933	-	expression tag
Val 934	-	expression tag
Thr 935	-	expression tag
Met 936	-	expression tag
Gln 937	-	expression tag
Leu 938	-	expression tag
Gln 939	-	expression tag
Asp 940	-	expression tag
Thr 941	-	expression tag
Pro 942	-	expression tag
Glu 943	-	expression tag
Lys 944	-	expression tag
Lys 945	-	expression tag
Thr 946	-	expression tag
Asn 947	-	expression tag
Ser 948	-	expression tag
Gly 949	-	expression tag
Gly 950	-	expression tag
Ser 951	-	expression tag
Val 952	-	expression tag
Phe 953	-	expression tag
Thr 954	-	expression tag
Leu 955	-	expression tag
Glu 956	-	expression tag
Asp 957	-	expression tag
Phe 958	-	expression tag
Val 959	-	expression tag
Gly 960	-	expression tag
Asp 961	-	expression tag
Trp 962	-	expression tag
Glu 963	-	expression tag
Gln 964	-	expression tag
Thr 965	-	expression tag
Ala 966	-	expression tag
Ala 967	-	expression tag
Tyr 968	-	expression tag
Asn 969	-	expression tag
Leu 970	-	expression tag
Asp 971	-	expression tag
Gln 972	-	expression tag
Val 973	-	expression tag
Leu 974	-	expression tag
Glu 975	-	expression tag
Gln 976	-	expression tag
Gly 977	-	expression tag
Gly 978	-	expression tag
Val 979	-	expression tag
Ser 980	-	expression tag
Ser 981	-	expression tag
Leu 982	-	expression tag
Leu 983	-	expression tag
Gln 984	-	expression tag
Asn 985	-	expression tag
Leu 986	-	expression tag
Ala 987	-	expression tag
Val 988	-	expression tag
Ser 989	-	expression tag
Val 990	-	expression tag
Thr 991	-	expression tag
Pro 992	-	expression tag
Ile 993	-	expression tag
Gln 994	-	expression tag
Arg 995	-	expression tag
Ile 996	-	expression tag
Val 997	-	expression tag
Arg 998	-	expression tag
Ser 999	-	expression tag
Gly 1000	-	expression tag
Glu 1001	-	expression tag
Asn 1002	-	expression tag
Ala 1003	-	expression tag
Leu 1004	-	expression tag
Lys 1005	-	expression tag
Ile 1006	-	expression tag
Asp 1007	-	expression tag
Ile 1008	-	expression tag
His 1009	-	expression tag
Val 1010	-	expression tag
Ile 1011	-	expression tag
Ile 1012	-	expression tag
Pro 1013	-	expression tag
Tyr 1014	-	expression tag
Glu 1015	-	expression tag
Gly 1016	-	expression tag
Leu 1017	-	expression tag
Ser 1018	-	expression tag
Ala 1019	-	expression tag
Asp 1020	-	expression tag
Gln 1021	-	expression tag
Met 1022	-	expression tag
Ala 1023	-	expression tag
Gln 1024	-	expression tag
Ile 1025	-	expression tag
Glu 1026	-	expression tag
Glu 1027	-	expression tag
Val 1028	-	expression tag
Phe 1029	-	expression tag
Lys 1030	-	expression tag
Val 1031	-	expression tag
Val 1032	-	expression tag
Tyr 1033	-	expression tag
Pro 1034	-	expression tag
Val 1035	-	expression tag
Asp 1036	-	expression tag
Asp 1037	-	expression tag
His 1038	-	expression tag
His 1039	-	expression tag
Phe 1040	-	expression tag
Lys 1041	-	expression tag
Val 1042	-	expression tag
Ile 1043	-	expression tag
Leu 1044	-	expression tag
Pro 1045	-	expression tag
Tyr 1046	-	expression tag
Gly 1047	-	expression tag
Thr 1048	-	expression tag
Leu 1049	-	expression tag
Val 1050	-	expression tag
Ile 1051	-	expression tag
Asp 1052	-	expression tag
Gly 1053	-	expression tag
Val 1054	-	expression tag
Thr 1055	-	expression tag
Pro 1056	-	expression tag
Asn 1057	-	expression tag
Met 1058	-	expression tag
Leu 1059	-	expression tag
Asn 1060	-	expression tag
Tyr 1061	-	expression tag
Phe 1062	-	expression tag
Gly 1063	-	expression tag
Arg 1064	-	expression tag
Pro 1065	-	expression tag
Tyr 1066	-	expression tag
Glu 1067	-	expression tag
Gly 1068	-	expression tag
Ile 1069	-	expression tag
Ala 1070	-	expression tag
Val 1071	-	expression tag
Phe 1072	-	expression tag
Asp 1073	-	expression tag
Gly 1074	-	expression tag
Lys 1075	-	expression tag
Lys 1076	-	expression tag
Ile 1077	-	expression tag
Thr 1078	-	expression tag
Val 1079	-	expression tag
Thr 1080	-	expression tag
Gly 1081	-	expression tag
Thr 1082	-	expression tag
Leu 1083	-	expression tag
Trp 1084	-	expression tag
Asn 1085	-	expression tag
Gly 1086	-	expression tag
Asn 1087	-	expression tag
Lys 1088	-	expression tag
Ile 1089	-	expression tag
Ile 1090	-	expression tag
Asp 1091	-	expression tag
Glu 1092	-	expression tag
Arg 1093	-	expression tag
Leu 1094	-	expression tag
Ile 1095	-	expression tag
Thr 1096	-	expression tag
Pro 1097	-	expression tag
Asp 1098	-	expression tag
Gly 1099	-	expression tag
Ser 1100	-	expression tag
Met 1101	-	expression tag
Leu 1102	-	expression tag
Phe 1103	-	expression tag
Arg 1104	-	expression tag
Val 1105	-	expression tag
Thr 1106	-	expression tag
Ile 1107	-	expression tag
Asn 1108	-	expression tag
Ser 1109	-	expression tag

B: 19 - 894 (UniProt: P41180)

PDB	External Database	Details
Trp -13	-	expression tag
Ser -12	-	expression tag
His -11	-	expression tag
Pro -10	-	expression tag
Gln -9	-	expression tag
Phe -8	-	expression tag
Glu -7	-	expression tag
Lys -6	-	expression tag
Gly -5	-	expression tag
Gly -4	-	expression tag
Gly -3	-	expression tag
Ser -2	-	expression tag
Gly -1	-	expression tag
Gly 0	-	expression tag
Gly 1	-	expression tag
Ser 2	-	expression tag
Gly 3	-	expression tag
Gly 4	-	expression tag
Ser 5	-	expression tag
Ala 6	-	expression tag
Trp 7	-	expression tag
Ser 8	-	expression tag
His 9	-	expression tag
Pro 10	-	expression tag
Gln 11	-	expression tag
Phe 12	-	expression tag
Glu 13	-	expression tag
Lys 14	-	expression tag
Gly 15	-	expression tag
Ser 16	-	expression tag
Ala 17	-	expression tag
Ala 18	-	expression tag
Thr 895	-	expression tag
Gly 896	-	expression tag
Ser 897	-	expression tag
Ser 898	-	expression tag
Thr 899	-	expression tag
Asn 900	-	expression tag
Asn 901	-	expression tag
Asn 902	-	expression tag
Glu 903	-	expression tag
Glu 904	-	expression tag
Glu 905	-	expression tag
Lys 906	-	expression tag
Ser 907	-	expression tag
Arg 908	-	expression tag
Leu 909	-	expression tag
Leu 910	-	expression tag
Glu 911	-	expression tag
Lys 912	-	expression tag
Glu 913	-	expression tag
Asn 914	-	expression tag
Arg 915	-	expression tag
Glu 916	-	expression tag
Leu 917	-	expression tag
Glu 918	-	expression tag
Lys 919	-	expression tag
Ile 920	-	expression tag
Ile 921	-	expression tag
Ala 922	-	expression tag
Glu 923	-	expression tag
Lys 924	-	expression tag
Glu 925	-	expression tag
Glu 926	-	expression tag
Arg 927	-	expression tag
Val 928	-	expression tag
Ser 929	-	expression tag
Glu 930	-	expression tag
Leu 931	-	expression tag
Arg 932	-	expression tag
His 933	-	expression tag
Gln 934	-	expression tag
Leu 935	-	expression tag
Gln 936	-	expression tag
Ser 937	-	expression tag
Arg 938	-	expression tag
Gln 939	-	expression tag
Gln 940	-	expression tag
Leu 941	-	expression tag
Lys 942	-	expression tag
Lys 943	-	expression tag
Thr 944	-	expression tag
Asn 945	-	expression tag

Sequence viewer

Contents of the asymmetric unit

Polymers	Number of chains	2
Polymers	Total formula weight	231844.0
Branched	Number of molecules	3
Branched	Total formula weight	1273.2
Non-Polymers*	Number of molecules	16
Non-Polymers*	Total formula weight	2781.9
All*	Total formula weight	235899.1

*Water molecules are not included.

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)