8SZF
Cryo-EM structure of cinacalcet-bound active-state human calcium-sensing receptor CaSR in lipid nanodiscs
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Extracellular calcium-sensing receptor | polymer | 1101 | 123821.0 | 1 | UniProt (P41180) Pfam (PF01094) Pfam (PF07562) Pfam (PF00003) | Homo sapiens (human) | CaR,CaSR,hCasR,Parathyroid cell calcium-sensing receptor 1,PCaR1 |
| 2 | B (B) | Extracellular calcium-sensing receptor | polymer | 959 | 108023.1 | 1 | UniProt (P41180) Pfam (PF01094) Pfam (PF07562) Pfam (PF00003) | Homo sapiens (human) | CaR,CaSR,hCasR,Parathyroid cell calcium-sensing receptor 1,PCaR1 |
| 3 | C, D, E (C, D, E) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 3 | In PDB GlyTouCan (G42666HT) | |||
| 4 | F, G, N, O, T (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 5 | Chemie (NAG) | |||
| 5 | H, P (A, B) | TRYPTOPHAN | non-polymer | 204.2 | 2 | Chemie (TRP) | |||
| 6 | I, J, K, Q (A, B) | CALCIUM ION | non-polymer | 40.1 | 4 | Chemie (CA) | |||
| 7 | L, R (A, B) | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) | |||
| 8 | M, S (A, B) | N-[(1R)-1-(naphthalen-1-yl)ethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine | non-polymer | 357.4 | 2 | Chemie (YP4) | |||
| 9 | U (B) | SPERMINE | non-polymer | 202.3 | 1 | Chemie (SPM) |
Sequence modifications
A: 19 - 894 (UniProt: P41180)
B: 19 - 894 (UniProt: P41180)
| PDB | External Database | Details |
|---|---|---|
| Asp 9 | - | expression tag |
| Tyr 10 | - | expression tag |
| Lys 11 | - | expression tag |
| Asp 12 | - | expression tag |
| Asp 13 | - | expression tag |
| Asp 14 | - | expression tag |
| Asp 15 | - | expression tag |
| Lys 16 | - | expression tag |
| Ala 17 | - | expression tag |
| Ala 18 | - | expression tag |
| Thr 895 | - | expression tag |
| Ser 896 | - | expression tag |
| Thr 897 | - | expression tag |
| Ser 898 | - | expression tag |
| Val 899 | - | expression tag |
| Thr 900 | - | expression tag |
| Ser 901 | - | expression tag |
| Val 902 | - | expression tag |
| Asn 903 | - | expression tag |
| Gln 904 | - | expression tag |
| Ala 905 | - | expression tag |
| Ser 906 | - | expression tag |
| Thr 907 | - | expression tag |
| Ser 908 | - | expression tag |
| Arg 909 | - | expression tag |
| Leu 910 | - | expression tag |
| Glu 911 | - | expression tag |
| Gly 912 | - | expression tag |
| Leu 913 | - | expression tag |
| Gln 914 | - | expression tag |
| Ser 915 | - | expression tag |
| Glu 916 | - | expression tag |
| Asn 917 | - | expression tag |
| His 918 | - | expression tag |
| Arg 919 | - | expression tag |
| Leu 920 | - | expression tag |
| Arg 921 | - | expression tag |
| Met 922 | - | expression tag |
| Lys 923 | - | expression tag |
| Ile 924 | - | expression tag |
| Thr 925 | - | expression tag |
| Glu 926 | - | expression tag |
| Leu 927 | - | expression tag |
| Asp 928 | - | expression tag |
| Lys 929 | - | expression tag |
| Asp 930 | - | expression tag |
| Leu 931 | - | expression tag |
| Glu 932 | - | expression tag |
| Glu 933 | - | expression tag |
| Val 934 | - | expression tag |
| Thr 935 | - | expression tag |
| Met 936 | - | expression tag |
| Gln 937 | - | expression tag |
| Leu 938 | - | expression tag |
| Gln 939 | - | expression tag |
| Asp 940 | - | expression tag |
| Thr 941 | - | expression tag |
| Pro 942 | - | expression tag |
| Glu 943 | - | expression tag |
| Lys 944 | - | expression tag |
| Lys 945 | - | expression tag |
| Thr 946 | - | expression tag |
| Asn 947 | - | expression tag |
| Ser 948 | - | expression tag |
| Gly 949 | - | expression tag |
| Gly 950 | - | expression tag |
| Ser 951 | - | expression tag |
| Val 952 | - | expression tag |
| Phe 953 | - | expression tag |
| Thr 954 | - | expression tag |
| Leu 955 | - | expression tag |
| Glu 956 | - | expression tag |
| Asp 957 | - | expression tag |
| Phe 958 | - | expression tag |
| Val 959 | - | expression tag |
| Gly 960 | - | expression tag |
| Asp 961 | - | expression tag |
| Trp 962 | - | expression tag |
| Glu 963 | - | expression tag |
| Gln 964 | - | expression tag |
| Thr 965 | - | expression tag |
| Ala 966 | - | expression tag |
| Ala 967 | - | expression tag |
| Tyr 968 | - | expression tag |
| Asn 969 | - | expression tag |
| Leu 970 | - | expression tag |
| Asp 971 | - | expression tag |
| Gln 972 | - | expression tag |
| Val 973 | - | expression tag |
| Leu 974 | - | expression tag |
| Glu 975 | - | expression tag |
| Gln 976 | - | expression tag |
| Gly 977 | - | expression tag |
| Gly 978 | - | expression tag |
| Val 979 | - | expression tag |
| Ser 980 | - | expression tag |
| Ser 981 | - | expression tag |
| Leu 982 | - | expression tag |
| Leu 983 | - | expression tag |
| Gln 984 | - | expression tag |
| Asn 985 | - | expression tag |
| Leu 986 | - | expression tag |
| Ala 987 | - | expression tag |
| Val 988 | - | expression tag |
| Ser 989 | - | expression tag |
| Val 990 | - | expression tag |
| Thr 991 | - | expression tag |
| Pro 992 | - | expression tag |
| Ile 993 | - | expression tag |
| Gln 994 | - | expression tag |
| Arg 995 | - | expression tag |
| Ile 996 | - | expression tag |
| Val 997 | - | expression tag |
| Arg 998 | - | expression tag |
| Ser 999 | - | expression tag |
| Gly 1000 | - | expression tag |
| Glu 1001 | - | expression tag |
| Asn 1002 | - | expression tag |
| Ala 1003 | - | expression tag |
| Leu 1004 | - | expression tag |
| Lys 1005 | - | expression tag |
| Ile 1006 | - | expression tag |
| Asp 1007 | - | expression tag |
| Ile 1008 | - | expression tag |
| His 1009 | - | expression tag |
| Val 1010 | - | expression tag |
| Ile 1011 | - | expression tag |
| Ile 1012 | - | expression tag |
| Pro 1013 | - | expression tag |
| Tyr 1014 | - | expression tag |
| Glu 1015 | - | expression tag |
| Gly 1016 | - | expression tag |
| Leu 1017 | - | expression tag |
| Ser 1018 | - | expression tag |
| Ala 1019 | - | expression tag |
| Asp 1020 | - | expression tag |
| Gln 1021 | - | expression tag |
| Met 1022 | - | expression tag |
| Ala 1023 | - | expression tag |
| Gln 1024 | - | expression tag |
| Ile 1025 | - | expression tag |
| Glu 1026 | - | expression tag |
| Glu 1027 | - | expression tag |
| Val 1028 | - | expression tag |
| Phe 1029 | - | expression tag |
| Lys 1030 | - | expression tag |
| Val 1031 | - | expression tag |
| Val 1032 | - | expression tag |
| Tyr 1033 | - | expression tag |
| Pro 1034 | - | expression tag |
| Val 1035 | - | expression tag |
| Asp 1036 | - | expression tag |
| Asp 1037 | - | expression tag |
| His 1038 | - | expression tag |
| His 1039 | - | expression tag |
| Phe 1040 | - | expression tag |
| Lys 1041 | - | expression tag |
| Val 1042 | - | expression tag |
| Ile 1043 | - | expression tag |
| Leu 1044 | - | expression tag |
| Pro 1045 | - | expression tag |
| Tyr 1046 | - | expression tag |
| Gly 1047 | - | expression tag |
| Thr 1048 | - | expression tag |
| Leu 1049 | - | expression tag |
| Val 1050 | - | expression tag |
| Ile 1051 | - | expression tag |
| Asp 1052 | - | expression tag |
| Gly 1053 | - | expression tag |
| Val 1054 | - | expression tag |
| Thr 1055 | - | expression tag |
| Pro 1056 | - | expression tag |
| Asn 1057 | - | expression tag |
| Met 1058 | - | expression tag |
| Leu 1059 | - | expression tag |
| Asn 1060 | - | expression tag |
| Tyr 1061 | - | expression tag |
| Phe 1062 | - | expression tag |
| Gly 1063 | - | expression tag |
| Arg 1064 | - | expression tag |
| Pro 1065 | - | expression tag |
| Tyr 1066 | - | expression tag |
| Glu 1067 | - | expression tag |
| Gly 1068 | - | expression tag |
| Ile 1069 | - | expression tag |
| Ala 1070 | - | expression tag |
| Val 1071 | - | expression tag |
| Phe 1072 | - | expression tag |
| Asp 1073 | - | expression tag |
| Gly 1074 | - | expression tag |
| Lys 1075 | - | expression tag |
| Lys 1076 | - | expression tag |
| Ile 1077 | - | expression tag |
| Thr 1078 | - | expression tag |
| Val 1079 | - | expression tag |
| Thr 1080 | - | expression tag |
| Gly 1081 | - | expression tag |
| Thr 1082 | - | expression tag |
| Leu 1083 | - | expression tag |
| Trp 1084 | - | expression tag |
| Asn 1085 | - | expression tag |
| Gly 1086 | - | expression tag |
| Asn 1087 | - | expression tag |
| Lys 1088 | - | expression tag |
| Ile 1089 | - | expression tag |
| Ile 1090 | - | expression tag |
| Asp 1091 | - | expression tag |
| Glu 1092 | - | expression tag |
| Arg 1093 | - | expression tag |
| Leu 1094 | - | expression tag |
| Ile 1095 | - | expression tag |
| Thr 1096 | - | expression tag |
| Pro 1097 | - | expression tag |
| Asp 1098 | - | expression tag |
| Gly 1099 | - | expression tag |
| Ser 1100 | - | expression tag |
| Met 1101 | - | expression tag |
| Leu 1102 | - | expression tag |
| Phe 1103 | - | expression tag |
| Arg 1104 | - | expression tag |
| Val 1105 | - | expression tag |
| Thr 1106 | - | expression tag |
| Ile 1107 | - | expression tag |
| Asn 1108 | - | expression tag |
| Ser 1109 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Trp -13 | - | expression tag |
| Ser -12 | - | expression tag |
| His -11 | - | expression tag |
| Pro -10 | - | expression tag |
| Gln -9 | - | expression tag |
| Phe -8 | - | expression tag |
| Glu -7 | - | expression tag |
| Lys -6 | - | expression tag |
| Gly -5 | - | expression tag |
| Gly -4 | - | expression tag |
| Gly -3 | - | expression tag |
| Ser -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Gly 0 | - | expression tag |
| Gly 1 | - | expression tag |
| Ser 2 | - | expression tag |
| Gly 3 | - | expression tag |
| Gly 4 | - | expression tag |
| Ser 5 | - | expression tag |
| Ala 6 | - | expression tag |
| Trp 7 | - | expression tag |
| Ser 8 | - | expression tag |
| His 9 | - | expression tag |
| Pro 10 | - | expression tag |
| Gln 11 | - | expression tag |
| Phe 12 | - | expression tag |
| Glu 13 | - | expression tag |
| Lys 14 | - | expression tag |
| Gly 15 | - | expression tag |
| Ser 16 | - | expression tag |
| Ala 17 | - | expression tag |
| Ala 18 | - | expression tag |
| Thr 895 | - | expression tag |
| Gly 896 | - | expression tag |
| Ser 897 | - | expression tag |
| Ser 898 | - | expression tag |
| Thr 899 | - | expression tag |
| Asn 900 | - | expression tag |
| Asn 901 | - | expression tag |
| Asn 902 | - | expression tag |
| Glu 903 | - | expression tag |
| Glu 904 | - | expression tag |
| Glu 905 | - | expression tag |
| Lys 906 | - | expression tag |
| Ser 907 | - | expression tag |
| Arg 908 | - | expression tag |
| Leu 909 | - | expression tag |
| Leu 910 | - | expression tag |
| Glu 911 | - | expression tag |
| Lys 912 | - | expression tag |
| Glu 913 | - | expression tag |
| Asn 914 | - | expression tag |
| Arg 915 | - | expression tag |
| Glu 916 | - | expression tag |
| Leu 917 | - | expression tag |
| Glu 918 | - | expression tag |
| Lys 919 | - | expression tag |
| Ile 920 | - | expression tag |
| Ile 921 | - | expression tag |
| Ala 922 | - | expression tag |
| Glu 923 | - | expression tag |
| Lys 924 | - | expression tag |
| Glu 925 | - | expression tag |
| Glu 926 | - | expression tag |
| Arg 927 | - | expression tag |
| Val 928 | - | expression tag |
| Ser 929 | - | expression tag |
| Glu 930 | - | expression tag |
| Leu 931 | - | expression tag |
| Arg 932 | - | expression tag |
| His 933 | - | expression tag |
| Gln 934 | - | expression tag |
| Leu 935 | - | expression tag |
| Gln 936 | - | expression tag |
| Ser 937 | - | expression tag |
| Arg 938 | - | expression tag |
| Gln 939 | - | expression tag |
| Gln 940 | - | expression tag |
| Leu 941 | - | expression tag |
| Lys 942 | - | expression tag |
| Lys 943 | - | expression tag |
| Thr 944 | - | expression tag |
| Asn 945 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 231844.0 | |
| Branched | Number of molecules | 3 |
| Total formula weight | 1273.2 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 2781.9 | |
| All* | Total formula weight | 235899.1 |
