9AYF

Structure of human calcium-sensing receptor in complex with Gi1 (miniGi1) protein in detergent

Summary for 9AYF

• Entry DOI: 10.2210/pdb9ayf/pdb
• EMDB information: 43990
• Descriptor: Isoform 1 of Extracellular calcium-sensing receptor, CALCIUM ION, 3-(2-chlorophenyl)-N-[(1R)-1-(3-methoxyphenyl)ethyl]propan-1-amine, ... (12 entities in total)
• Functional Keywords: calcium-sensing receptor, g-protein-coupled receptor, g protein, signal transduction, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 315441.34

Authors

Zuo, H.,Park, J.,Frangaj, A.,Ye, J.,Lu, G.,Manning, J.J.,Asher, W.B.,Lu, Z.,Hu, G.,Wang, L.,Mendez, J.,Eng, E.,Zhang, Z.,Lin, X.,Grasucci, R.,Hendrickson, W.A.,Clarke, O.B.,Javitch, J.A.,Conigrave, A.D.,Fan, Q.R. (deposition date: 2024-03-07, release date: 2024-04-17)

• Primary citation: Zuo, H.,Park, J.,Frangaj, A.,Ye, J.,Lu, G.,Manning, J.J.,Asher, W.B.,Lu, Z.,Hu, G.,Wang, L.,Mendez, J.,Eng, E.,Zhang, Z.,Lin, X.,Grasucci, R.,Hendrickson, W.A.,Clarke, O.B.,Javitch, J.A.,Conigrave, A.D.,Fan, Q.R.; Promiscuous G-protein activation by the calcium-sensing receptor; Nature, 2024; DOI: 10.1038/s41586-024-07331-1

Experimental method

ELECTRON MICROSCOPY (3.6 Å)