8WPU

Human calcium-sensing receptor(CaSR) bound to cinacalcet in complex with Gq protein

Summary for 8WPU

• Entry DOI: 10.2210/pdb8wpu/pdb
• Related: 8WPG
• EMDB information: 37716 37724
• Descriptor: Extracellular calcium-sensing receptor,calcium-sensing receptor, CALCIUM ION, PHOSPHATE ION, ... (12 entities in total)
• Functional Keywords: gpcr-g protein complex, allosteric modulator, activation, dimeric, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 354724.40

Authors

Ling, S.L.,Meng, X.Y.,Tian, C.L. (deposition date: 2023-10-10, release date: 2023-11-22, Last modification date: 2024-02-21)

• Primary citation: Ling, S.,Meng, X.,Zhang, Y.,Xia, Z.,Zhou, Y.,Yang, F.,Shi, P.,Shi, C.,Tian, C.; Structural insights into asymmetric activation of the calcium-sensing receptor-G q complex.; Cell Res., 34:169-172, 2024; PubMed: 37919470; DOI: 10.1038/s41422-023-00892-2

Experimental method

ELECTRON MICROSCOPY (3.1 Å)