8WPU
Human calcium-sensing receptor(CaSR) bound to cinacalcet in complex with Gq protein
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | B, A | Extracellular calcium-sensing receptor,calcium-sensing receptor | polymer | 1076 | 120641.6 | 2 | UniProt (P41180) Pfam (PF01094) Pfam (PF07562) Pfam (PF00003) In PDB | Homo sapiens (human) | CaR,CaSR,hCasR,Parathyroid cell calcium-sensing receptor 1,PCaR1 |
2 | G | G subunit q (Gi2-mini-Gq chimeric) | polymer | 246 | 28084.8 | 1 | Pfam (PF00503) UniProt (by SIFTS) (P04899) UniProt (by SIFTS) (P63092) In PDB | Homo sapiens | |
3 | C | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 376 | 40924.7 | 1 | UniProt (P62873) Pfam (PF00400) In PDB | Homo sapiens (human) | |
4 | D | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) In PDB | Homo sapiens (human) | G gamma-I |
5 | E | ScFv16 | polymer | 297 | 31870.6 | 1 | Rattus norvegicus | ||
6 | F, H | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
7 | B, A | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 9 | Chemie (NAG) | |||
8 | A, B | N-[(1R)-1-(naphthalen-1-yl)ethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine | non-polymer | 357.4 | 2 | Chemie (YP4) | |||
9 | B, A | TRYPTOPHAN | non-polymer | 204.2 | 2 | Chemie (TRP) | |||
10 | B, A | CALCIUM ION | non-polymer | 40.1 | 4 | Chemie (CA) | |||
11 | A, B | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) | |||
12 | B | CHOLESTEROL | non-polymer | 386.7 | 1 | Chemie (CLR) |
Sequence modifications
B, A: 20 - 892 (UniProt: P41180)
B, A: 893 - 1065 (PDB: 8WPU)
C: 2 - 340 (UniProt: P62873)
PDB | External Database | Details |
---|---|---|
Met -10 | - | initiating methionine |
Lys -9 | - | expression tag |
Thr -8 | - | expression tag |
Ile -7 | - | expression tag |
Ile -6 | - | expression tag |
Ala -5 | - | expression tag |
Leu -4 | - | expression tag |
Ser -3 | - | expression tag |
Tyr -2 | - | expression tag |
Ile -1 | - | expression tag |
Phe 0 | - | expression tag |
Cys 1 | - | expression tag |
Leu 2 | - | expression tag |
Val 3 | - | expression tag |
Phe 4 | - | expression tag |
Ala 5 | - | expression tag |
Asp 6 | - | expression tag |
Tyr 7 | - | expression tag |
Lys 8 | - | expression tag |
Asp 9 | - | expression tag |
Asp 10 | - | expression tag |
Asp 11 | - | expression tag |
Asp 12 | - | expression tag |
Glu 13 | - | expression tag |
Asn 14 | - | expression tag |
Leu 15 | - | expression tag |
Tyr 16 | - | expression tag |
Phe 17 | - | expression tag |
Gln 18 | - | expression tag |
Gly 19 | - | expression tag |
C: 2 - 340 (UniProt: P62873)
PDB | External Database | Details |
---|---|---|
His -9 | - | expression tag |
His -8 | - | expression tag |
His -7 | - | expression tag |
His -6 | - | expression tag |
His -5 | - | expression tag |
His -4 | - | expression tag |
Gly -3 | - | expression tag |
Ser -2 | - | expression tag |
Leu -1 | - | expression tag |
Leu 0 | - | expression tag |
Gln 1 | - | expression tag |
Gly 341 | - | expression tag |
Ser 342 | - | expression tag |
Ser 343 | - | expression tag |
Gly 344 | - | expression tag |
Gly 345 | - | expression tag |
Gly 346 | - | expression tag |
Gly 347 | - | expression tag |
Ser 348 | - | expression tag |
Gly 349 | - | expression tag |
Gly 350 | - | expression tag |
Gly 351 | - | expression tag |
Gly 352 | - | expression tag |
Ser 353 | - | expression tag |
Ser 354 | - | expression tag |
Gly 355 | - | expression tag |
Val 356 | - | expression tag |
Ser 357 | - | expression tag |
Gly 358 | - | expression tag |
Trp 359 | - | expression tag |
Arg 360 | - | expression tag |
Leu 361 | - | expression tag |
Phe 362 | - | expression tag |
Lys 363 | - | expression tag |
Lys 364 | - | expression tag |
Ile 365 | - | expression tag |
Ser 366 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 350024.5 | |
Branched | Number of molecules | 2 |
Total formula weight | 848.8 | |
Non-Polymers* | Number of molecules | 20 |
Total formula weight | 3851.1 | |
All* | Total formula weight | 354724.4 |