8WPG

Human calcium-sensing receptor bound with cinacalcet in detergent

Summary for 8WPG

• Entry DOI: 10.2210/pdb8wpg/pdb
• EMDB information: 37716
• Descriptor: Extracellular calcium-sensing receptor, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• Functional Keywords: gpcr, allosteric modulator, activation, dimeric, membrane protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 208360.58

Authors

Ling, S.L.,Meng, X.Y.,Tian, C.L. (deposition date: 2023-10-10, release date: 2023-11-22, Last modification date: 2024-02-21)

• Primary citation: Ling, S.,Meng, X.,Zhang, Y.,Xia, Z.,Zhou, Y.,Yang, F.,Shi, P.,Shi, C.,Tian, C.; Structural insights into asymmetric activation of the calcium-sensing receptor-G q complex.; Cell Res., 34:169-172, 2024; PubMed: 37919470; DOI: 10.1038/s41422-023-00892-2

Experimental method

ELECTRON MICROSCOPY (2.7 Å)