8WPG

Human calcium-sensing receptor bound with cinacalcet in detergent

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	B, A	Extracellular calcium-sensing receptor	polymer	903	102041.7	2	UniProt (P41180) Pfam (PF01094) Pfam (PF07562) Pfam (PF00003) In PDB	Homo sapiens (human)	CaR,CaSR,hCasR,Parathyroid cell calcium-sensing receptor 1,PCaR1
2	C, D, E, F	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	4	In PDB GlyTouCan (G42666HT)
3	B, A	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	5	Chemie (NAG)
4	B, A	TRYPTOPHAN	non-polymer		204.2	2	Chemie (TRP)
5	B, A	CALCIUM ION	non-polymer		40.1	4	Chemie (CA)
6	B, A	PHOSPHATE ION	non-polymer		95.0	2	Chemie (PO4)
7	B, A	N-[(1R)-1-(naphthalen-1-yl)ethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine	non-polymer		357.4	2	Chemie (YP4)

Sequence modifications

B, A: 20 - 892 (UniProt: P41180)

PDB	External Database	Details
Met -10	-	initiating methionine
Lys -9	-	expression tag
Thr -8	-	expression tag
Ile -7	-	expression tag
Ile -6	-	expression tag
Ala -5	-	expression tag
Leu -4	-	expression tag
Ser -3	-	expression tag
Tyr -2	-	expression tag
Ile -1	-	expression tag
Phe 0	-	expression tag
Cys 1	-	expression tag
Leu 2	-	expression tag
Val 3	-	expression tag
Phe 4	-	expression tag
Ala 5	-	expression tag
Asp 6	-	expression tag
Tyr 7	-	expression tag
Lys 8	-	expression tag
Asp 9	-	expression tag
Asp 10	-	expression tag
Asp 11	-	expression tag
Asp 12	-	expression tag
Glu 13	-	expression tag
Asn 14	-	expression tag
Leu 15	-	expression tag
Tyr 16	-	expression tag
Phe 17	-	expression tag
Gln 18	-	expression tag
Gly 19	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	204083.4
Branched	Number of molecules	4
	Total formula weight	1697.6
Non-Polymers*	Number of molecules	15
	Total formula weight	2579.6
All*	Total formula weight	208360.6

*Water molecules are not included.