8XQK
 
 | | The Crystal Structure of Apaf from Biortus. | | 分子名称: | Apoptotic protease-activating factor 1, PHOSPHATE ION | | 著者 | Wang, F, Cheng, W, Lv, Z, Ju, C, Ni, C. | | 登録日 | 2024-01-05 | | 公開日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | | 主引用文献 | The Crystal Structure of Apaf from Biortus.
To Be Published
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8JOL
 | | cryo-EM structure of the CED-4/CED-3 holoenzyme | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Cell death protein 3, Cell death protein 4, ... | | 著者 | Li, Y, Tian, L, Zhang, Y, Shi, Y. | | 登録日 | 2023-06-07 | | 公開日 | 2023-06-28 | | 最終更新日 | 2023-11-15 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Structural insights into CED-3 activation.
Life Sci Alliance, 6, 2023
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8JO0
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8JNS
 | | cryo-EM structure of a CED-4 hexamer | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Cell death protein 4, MAGNESIUM ION | | 著者 | Li, Y, Shi, Y. | | 登録日 | 2023-06-06 | | 公開日 | 2023-06-28 | | 最終更新日 | 2023-08-02 | | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | | 主引用文献 | Structural insights into CED-3 activation.
Life Sci Alliance, 6, 2023
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8FW9
 | | Cryo-EM structure of full-length human NLRC4 inflammasome with C12 symmetry | | 分子名称: | NLR family CARD domain-containing protein 4 | | 著者 | Matico, R.E, Yu, X, Miller, R, Somani, S, Ricketts, M.D, Kumar, N, Steele, R.A, Medley, Q, Berger, S, Faustin, B, Sharma, S. | | 登録日 | 2023-01-20 | | 公開日 | 2024-01-03 | | 最終更新日 | 2024-01-31 | | 実験手法 | ELECTRON MICROSCOPY (4.46 Å) | | 主引用文献 | Structural basis of the human NAIP/NLRC4 inflammasome assembly and pathogen sensing.
Nat.Struct.Mol.Biol., 31, 2024
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8FW2
 | | Cryo-EM structure of full-length human NLRC4 inflammasome with C11 symmetry | | 分子名称: | NLR family CARD domain-containing protein 4 | | 著者 | Matico, R.E, Yu, X, Miller, R, Somani, S, Ricketts, M.D, Kumar, N, Steele, R.A, Medley, Q, Berger, S, Faustin, B, Sharma, S. | | 登録日 | 2023-01-20 | | 公開日 | 2024-01-03 | | 最終更新日 | 2024-01-31 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Structural basis of the human NAIP/NLRC4 inflammasome assembly and pathogen sensing.
Nat.Struct.Mol.Biol., 31, 2024
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8FVU
 | | Cryo-EM structure of human Needle/NAIP/NLRC4 (R288A) | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Baculoviral IAP repeat-containing protein 1, Lethal factor,Type III secretion system protein, ... | | 著者 | Matico, R.E, Yu, X, Miller, R, Somani, S, Ricketts, M.D, Kumar, N, Steele, R.A, Medley, Q, Berger, S, Faustin, B, Sharma, S. | | 登録日 | 2023-01-19 | | 公開日 | 2024-01-03 | | 最終更新日 | 2024-01-31 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Structural basis of the human NAIP/NLRC4 inflammasome assembly and pathogen sensing.
Nat.Struct.Mol.Biol., 31, 2024
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8CZO
 | | Cryo-EM structure of BCL10 CARD - MALT1 DD filament | | 分子名称: | B-cell lymphoma/leukemia 10, Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | | 著者 | David, L, Wu, H. | | 登録日 | 2022-05-25 | | 公開日 | 2022-06-22 | | 最終更新日 | 2022-08-17 | | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | | 主引用文献 | BCL10 Mutations Define Distinct Dependencies Guiding Precision Therapy for DLBCL.
Cancer Discov, 12, 2022
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8CZD
 | | Cryo-EM structure of BCL10 R58Q filament | | 分子名称: | B-cell lymphoma/leukemia 10 | | 著者 | David, L, Wu, H. | | 登録日 | 2022-05-24 | | 公開日 | 2022-06-22 | | 最終更新日 | 2024-02-14 | | 実験手法 | ELECTRON MICROSCOPY (4.6 Å) | | 主引用文献 | BCL10 Mutations Define Distinct Dependencies Guiding Precision Therapy for DLBCL.
Cancer Discov, 12, 2022
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7NIQ
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7NIC
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7NGA
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7KEU
 | | Cryo-EM structure of the Caspase-1-CARD:ASC-CARD octamer | | 分子名称: | Apoptosis-associated speck-like protein containing a CARD, Caspase-1 | | 著者 | Hollingsworth, L.R, David, L, Li, Y, Ruan, J, Wu, H. | | 登録日 | 2020-10-12 | | 公開日 | 2020-11-25 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes.
Nat Commun, 12, 2021
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7JN7
 | | Human DPP9-CARD8 complex | | 分子名称: | Caspase recruitment domain-containing protein 8, Dipeptidyl peptidase 9, [(2~{R})-1-[(2~{R})-2-azanyl-3-methyl-butanoyl]pyrrolidin-2-yl]boronic acid | | 著者 | Sharif, H, Hollingsworth, L.R. | | 登録日 | 2020-08-04 | | 公開日 | 2021-05-19 | | 最終更新日 | 2021-07-28 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Dipeptidyl peptidase 9 sets a threshold for CARD8 inflammasome formation by sequestering its active C-terminal fragment.
Immunity, 54, 2021
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7JKQ
 | | Human DPP9-CARD8 complex | | 分子名称: | Caspase recruitment domain-containing protein 8, Dipeptidyl peptidase 9 | | 著者 | Sharif, H, Hollingsworth, L.R. | | 登録日 | 2020-07-28 | | 公開日 | 2021-05-26 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Dipeptidyl peptidase 9 sets a threshold for CARD8 inflammasome formation by sequestering its active C-terminal fragment.
Immunity, 54, 2021
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7DNJ
 | | K63-polyUb MDA5CARDs complex | | 分子名称: | Interferon-induced helicase C domain-containing protein 1, Ubiquitin | | 著者 | Song, B, Chen, Y, Luo, D.H, Zheng, J. | | 登録日 | 2020-12-09 | | 公開日 | 2021-10-13 | | 最終更新日 | 2022-02-16 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Ordered assembly of the cytosolic RNA-sensing MDA5-MAVS signaling complex via binding to unanchored K63-linked poly-ubiquitin chains.
Immunity, 54, 2021
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7DNI
 | | MDA5 CARDs-MAVS CARD polyUb complex | | 分子名称: | Interferon-induced helicase C domain-containing protein 1, Mitochondrial antiviral-signaling protein, Ubiquitin | | 著者 | Song, B, Chen, Y, Luo, D.H, Zheng, J. | | 登録日 | 2020-12-09 | | 公開日 | 2021-10-13 | | 最終更新日 | 2022-02-16 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Ordered assembly of the cytosolic RNA-sensing MDA5-MAVS signaling complex via binding to unanchored K63-linked poly-ubiquitin chains.
Immunity, 54, 2021
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7CRW
 | | Cryo-EM structure of rNLRP1-rDPP9 complex | | 分子名称: | Dipeptidyl peptidase 9, NLR family protein 1 | | 著者 | Huang, M.H, Zhang, X.X, Wang, J, Chai, J.J. | | 登録日 | 2020-08-14 | | 公開日 | 2021-03-24 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3.18 Å) | | 主引用文献 | Structural and biochemical mechanisms of NLRP1 inhibition by DPP9.
Nature, 592, 2021
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7BKP
 | | CryoEM structure of disease related M854K MDA5-dsRNA filament in complex with ATP | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Interferon-induced helicase C domain-containing protein 1, MAGNESIUM ION, ... | | 著者 | Singh, R, Herrero del Valle, A, Yu, Q, Modis, Y. | | 登録日 | 2021-01-16 | | 公開日 | 2021-11-17 | | 最終更新日 | 2021-12-01 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | MDA5 disease variant M854K prevents ATP-dependent structural discrimination of viral and cellular RNA.
Nat Commun, 12, 2021
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6XKK
 | | Cryo-EM structure of the NLRP1-CARD filament | | 分子名称: | NACHT, LRR and PYD domains-containing protein 1 | | 著者 | Hollingsworth, L.R, David, L, Li, Y, Sharif, H, Fontana, P, Fu, T, Wu, H. | | 登録日 | 2020-06-26 | | 公開日 | 2020-11-25 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (3.72 Å) | | 主引用文献 | Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes.
Nat Commun, 12, 2021
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6XKJ
 | | Cryo-EM structure of CARD8-CARD filament | | 分子名称: | Caspase recruitment domain-containing protein 8 | | 著者 | Hollingsworth, L.R, David, L, Li, Y, Sharif, H, Fontana, P, Fu, T, Wu, H. | | 登録日 | 2020-06-26 | | 公開日 | 2020-11-25 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (3.54 Å) | | 主引用文献 | Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes.
Nat Commun, 12, 2021
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6X6C
 | | Cryo-EM structure of NLRP1-DPP9-VbP complex | | 分子名称: | Dipeptidyl peptidase 9, NACHT, LRR and PYD domains-containing protein 1, ... | | 著者 | Hollingsworth, L.R, Sharif, H, Griswold, A.R, Fontana, P, Mintseris, J, Dagbay, K.B, Paulo, J.A, Gygi, S.P, Bachovchin, D.A, Wu, H. | | 登録日 | 2020-05-27 | | 公開日 | 2021-03-10 | | 最終更新日 | 2021-05-12 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | DPP9 sequesters the C terminus of NLRP1 to repress inflammasome activation.
Nature, 592, 2021
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6X6A
 | | Cryo-EM structure of NLRP1-DPP9 complex | | 分子名称: | Dipeptidyl peptidase 9, NACHT, LRR and PYD domains-containing protein 1 | | 著者 | Hollingsworth, L.R, Sharif, H, Griswold, A.R, Fontana, P, Mintseris, J, Dagbay, K.B, Paulo, J.A, Gygi, S.P, Bachovchin, D.A, Wu, H. | | 登録日 | 2020-05-27 | | 公開日 | 2021-03-10 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | DPP9 sequesters the C terminus of NLRP1 to repress inflammasome activation.
Nature, 592, 2021
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6N2P
 | | Helical assembly of the CARD9 CARD | | 分子名称: | Caspase recruitment domain-containing protein 9 | | 著者 | Holliday, M.J, Rohou, A, Arthur, C.P, Dueber, E.C, Fairbrother, W.J. | | 登録日 | 2018-11-13 | | 公開日 | 2019-07-03 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Structures of autoinhibited and polymerized forms of CARD9 reveal mechanisms of CARD9 and CARD11 activation.
Nat Commun, 10, 2019
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6N2M
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