7NIQ

CryoEM structure of disease related M854K MDA5-dsRNA filament in complex with ADP-AlF4(Major class)

Summary for 7NIQ

• Entry DOI: 10.2210/pdb7niq/pdb
• EMDB information: 12288
• Descriptor: Interferon-induced helicase C domain-containing protein 1, RNA (5'-R(P*CP*AP*AP*GP*CP*CP*GP*AP*GP*GP*AP*GP*AP*U)-3'), RNA (5'-R(P*AP*UP*CP*UP*CP*CP*UP*CP*GP*GP*CP*UP*UP*G)-3'), ... (6 entities in total)
• Functional Keywords: protein-rna complex, helical filament, atpase, innate immune receptor, immune system, antiviral protein
• Biological source: Mus musculus (House Mouse); More
• Total number of polymer chains: 3
• Total formula weight: 125643.36

Authors

Yu, Q.,Modis, Y. (deposition date: 2021-02-13, release date: 2021-11-17, Last modification date: 2021-12-01)

• Primary citation: Yu, Q.,Herrero Del Valle, A.,Singh, R.,Modis, Y.; MDA5 disease variant M854K prevents ATP-dependent structural discrimination of viral and cellular RNA.; Nat Commun, 12:6668-6668, 2021; PubMed: 34795277; DOI: 10.1038/s41467-021-27062-5

Experimental method

ELECTRON MICROSCOPY (4.3 Å)