7NIQ

CryoEM structure of disease related M854K MDA5-dsRNA filament in complex with ADP-AlF4(Major class)

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0000166	molecular_function	nucleotide binding
B	0002376	biological_process	immune system process
B	0003677	molecular_function	DNA binding
B	0003723	molecular_function	RNA binding
B	0003724	molecular_function	RNA helicase activity
B	0003725	molecular_function	double-stranded RNA binding
B	0003727	molecular_function	single-stranded RNA binding
B	0004386	molecular_function	helicase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0007165	biological_process	signal transduction
B	0008270	molecular_function	zinc ion binding
B	0009299	biological_process	mRNA transcription
B	0009615	biological_process	response to virus
B	0016787	molecular_function	hydrolase activity
B	0016887	molecular_function	ATP hydrolysis activity
B	0016925	biological_process	protein sumoylation
B	0019904	molecular_function	protein domain specific binding
B	0032727	biological_process	positive regulation of interferon-alpha production
B	0032728	biological_process	positive regulation of interferon-beta production
B	0032755	biological_process	positive regulation of interleukin-6 production
B	0032760	biological_process	positive regulation of tumor necrosis factor production
B	0038187	molecular_function	pattern recognition receptor activity
B	0039530	biological_process	MDA-5 signaling pathway
B	0042802	molecular_function	identical protein binding
B	0043021	molecular_function	ribonucleoprotein complex binding
B	0045071	biological_process	negative regulation of viral genome replication
B	0045087	biological_process	innate immune response
B	0046872	molecular_function	metal ion binding
B	0051259	biological_process	protein complex oligomerization
B	0051607	biological_process	defense response to virus
B	0060337	biological_process	type I interferon-mediated signaling pathway
B	0060760	biological_process	positive regulation of response to cytokine stimulus
B	0071360	biological_process	cellular response to exogenous dsRNA
B	0098586	biological_process	cellular response to virus
B	0140374	biological_process	antiviral innate immune response

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	193
Details	Domain: {"description":"Helicase ATP-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01125","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by RIOK3","evidences":[{"source":"UniProtKB","id":"Q9BYX4","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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