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7NIQ

CryoEM structure of disease related M854K MDA5-dsRNA filament in complex with ADP-AlF4(Major class)

Functional Information from GO Data
ChainGOidnamespacecontents
B0002376biological_processimmune system process
B0003677molecular_functionDNA binding
B0003723molecular_functionRNA binding
B0003724molecular_functionRNA helicase activity
B0003725molecular_functiondouble-stranded RNA binding
B0003727molecular_functionsingle-stranded RNA binding
B0004386molecular_functionhelicase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0008270molecular_functionzinc ion binding
B0009615biological_processresponse to virus
B0016787molecular_functionhydrolase activity
B0016887molecular_functionATP hydrolysis activity
B0016925biological_processprotein sumoylation
B0019904molecular_functionprotein domain specific binding
B0032727biological_processpositive regulation of interferon-alpha production
B0032728biological_processpositive regulation of interferon-beta production
B0032755biological_processpositive regulation of interleukin-6 production
B0032760biological_processpositive regulation of tumor necrosis factor production
B0038187molecular_functionpattern recognition receptor activity
B0039530biological_processMDA-5 signaling pathway
B0042802molecular_functionidentical protein binding
B0043021molecular_functionribonucleoprotein complex binding
B0045071biological_processnegative regulation of viral genome replication
B0045087biological_processinnate immune response
B0046872molecular_functionmetal ion binding
B0051259biological_processprotein complex oligomerization
B0051607biological_processdefense response to virus
B0060337biological_processtype I interferon-mediated signaling pathway
B0060760biological_processpositive regulation of response to cytokine stimulus
B0071360biological_processcellular response to exogenous dsRNA
B0098586biological_processcellular response to virus
B0140374biological_processantiviral innate immune response
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01125
ChainResidueDetails
BCYS907
BCYS910
BCYS962
BCYS964

site_idSWS_FT_FI2
Number of Residues3
DetailsSITE: Cleavage
ChainResidueDetails
BASP208
BASP216
BASP251

site_idSWS_FT_FI3
Number of Residues3
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:21183079
ChainResidueDetails
BSER289
BSER291
BSER302

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:17242355, ECO:0007744|PubMed:21183079
ChainResidueDetails
BSER645
BSER648

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphoserine; by RIOK3 => ECO:0000250|UniProtKB:Q9BYX4
ChainResidueDetails
BSER828

site_idSWS_FT_FI6
Number of Residues3
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ISG15) => ECO:0000250|UniProtKB:Q9BYX4
ChainResidueDetails
BLYS23
BLYS43

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PDB entries from 2024-07-17

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