7BKP

CryoEM structure of disease related M854K MDA5-dsRNA filament in complex with ATP

Summary for 7BKP

• Entry DOI: 10.2210/pdb7bkp/pdb
• EMDB information: 11937 12092 12213
• Descriptor: Interferon-induced helicase C domain-containing protein 1, RNA (5'-R(P*CP*UP*CP*UP*CP*CP*UP*CP*GP*GP*CP*UP*UP*G)-3'), RNA (5'-R(P*CP*AP*AP*GP*CP*CP*GP*AP*GP*GP*AP*GP*AP*G)-3'), ... (6 entities in total)
• Functional Keywords: protein-rna complex, helical filament, atpase, innate immune receptor, immune system
• Biological source: Mus musculus (Mouse); More
• Total number of polymer chains: 3
• Total formula weight: 125659.69

Authors

Singh, R.,Herrero del Valle, A.,Yu, Q.,Modis, Y. (deposition date: 2021-01-16, release date: 2021-11-17, Last modification date: 2021-12-01)

• Primary citation: Yu, Q.,Herrero Del Valle, A.,Singh, R.,Modis, Y.; MDA5 disease variant M854K prevents ATP-dependent structural discrimination of viral and cellular RNA.; Nat Commun, 12:6668-6668, 2021; PubMed: 34795277; DOI: 10.1038/s41467-021-27062-5

Experimental method

ELECTRON MICROSCOPY (2.8 Å)