6XKJ
Cryo-EM structure of CARD8-CARD filament
Summary for 6XKJ
Entry DOI | 10.2210/pdb6xkj/pdb |
EMDB information | 22219 22220 22233 |
Descriptor | Caspase recruitment domain-containing protein 8 (1 entity in total) |
Functional Keywords | filament, inflammasome, signaling, upa, fiind, card, nlrp1, immune system |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 16 |
Total formula weight | 161653.97 |
Authors | Hollingsworth, L.R.,David, L.,Li, Y.,Sharif, H.,Fontana, P.,Fu, T.,Wu, H. (deposition date: 2020-06-26, release date: 2020-11-25, Last modification date: 2024-03-06) |
Primary citation | Robert Hollingsworth, L.,David, L.,Li, Y.,Griswold, A.R.,Ruan, J.,Sharif, H.,Fontana, P.,Orth-He, E.L.,Fu, T.M.,Bachovchin, D.A.,Wu, H. Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes. Nat Commun, 12:189-189, 2021 Cited by PubMed: 33420033DOI: 10.1038/s41467-020-20320-y PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.54 Å) |
Structure validation
Download full validation report