6XKK

Cryo-EM structure of the NLRP1-CARD filament

Summary for 6XKK

Entry DOI	10.2210/pdb6xkk/pdb
EMDB information	22219 22220 22233
Descriptor	NACHT, LRR and PYD domains-containing protein 1 (1 entity in total)
Functional Keywords	filament, inflammasome, signaling, upa, card, fiind, nlrp1, immune system
Biological source	Homo sapiens (Human)
Total number of polymer chains	44
Total formula weight	490107.86
Authors	Hollingsworth, L.R.,David, L.,Li, Y.,Sharif, H.,Fontana, P.,Fu, T.,Wu, H. (deposition date: 2020-06-26, release date: 2020-11-25, Last modification date: 2024-03-06)
Primary citation	Robert Hollingsworth, L.,David, L.,Li, Y.,Griswold, A.R.,Ruan, J.,Sharif, H.,Fontana, P.,Orth-He, E.L.,Fu, T.M.,Bachovchin, D.A.,Wu, H. Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes. Nat Commun, 12:189-189, 2021 Cited by PubMed: 33420033 DOI: 10.1038/s41467-020-20320-y PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.72 Å)

Structure validation