7JN7

Human DPP9-CARD8 complex

Summary for 7JN7

Entry DOI	10.2210/pdb7jn7/pdb
EMDB information	22402
Descriptor	Dipeptidyl peptidase 9, Caspase recruitment domain-containing protein 8, [(2~{R})-1-[(2~{R})-2-azanyl-3-methyl-butanoyl]pyrrolidin-2-yl]boronic acid (3 entities in total)
Functional Keywords	card8, dpp9, inflammasome, val-boropro (vbp), talabostat, innate immunity, immune system, hydrolase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	325385.86
Authors	Sharif, H.,Hollingsworth, L.R. (deposition date: 2020-08-04, release date: 2021-05-19, Last modification date: 2021-07-28)
Primary citation	Sharif, H.,Hollingsworth, L.R.,Griswold, A.R.,Hsiao, J.C.,Wang, Q.,Bachovchin, D.A.,Wu, H. Dipeptidyl peptidase 9 sets a threshold for CARD8 inflammasome formation by sequestering its active C-terminal fragment. Immunity, 54:1392-, 2021 Cited by PubMed: 34019797 DOI: 10.1016/j.immuni.2021.04.024 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.3 Å)

Structure validation