7JN7

Human DPP9-CARD8 complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D (A, D)	Dipeptidyl peptidase 9	polymer	891	101762.0	2	UniProt (Q86TI2) Pfam (PF19520) Pfam (PF00930) Pfam (PF00326)	Homo sapiens (Human)	DP9,Dipeptidyl peptidase IV-related protein 2,DPRP-2,Dipeptidyl peptidase IX,DPP IX,Dipeptidyl peptidase-like protein 9,DPLP9
2	B, C (B, C)	Caspase recruitment domain-containing protein 8	polymer	537	60716.9	2	UniProt (Q9Y2G2) Pfam (PF13553) Pfam (PF00619)	Homo sapiens (Human)	Apoptotic protein NDPP1,CARD-inhibitor of NF-kappa-B-activating ligand,CARDINAL,DACAR,Tumor up-regulated CARD-containing antagonist of CASP9,TUCAN,CARD8
3	E, F (A, D)	[(2~{R})-1-[(2~{R})-2-azanyl-3-methyl-butanoyl]pyrrolidin-2-yl]boronic acid	non-polymer		214.1	2	Chemie (GK2)

Sequence modifications

A, D: 1 - 863 (UniProt: Q86TI2)

PDB	External Database	Details
Met -27	-	expression tag
Ser -26	-	expression tag
Tyr -25	-	expression tag
Tyr -24	-	expression tag
His -23	-	expression tag
His -22	-	expression tag
His -21	-	expression tag
His -20	-	expression tag
His -19	-	expression tag
His -18	-	expression tag
Asp -17	-	expression tag
Tyr -16	-	expression tag
Asp -15	-	expression tag
Ile -14	-	expression tag
Pro -13	-	expression tag
Thr -12	-	expression tag
Thr -11	-	expression tag
Glu -10	-	expression tag
Asn -9	-	expression tag
Leu -8	-	expression tag
Tyr -7	-	expression tag
Phe -6	-	expression tag
Gln -5	-	expression tag
Gly -4	-	expression tag
Ala -3	-	expression tag
Met -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	324957.7
Non-Polymers*	Number of molecules	2
	Total formula weight	428.1
All*	Total formula weight	325385.9

*Water molecules are not included.