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7JN7

Human DPP9-CARD8 complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0004177molecular_functionaminopeptidase activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005874cellular_componentmicrotubule
A0006508biological_processproteolysis
A0008236molecular_functionserine-type peptidase activity
A0008239molecular_functiondipeptidyl-peptidase activity
A0031252cellular_componentcell leading edge
A0042802molecular_functionidentical protein binding
A0043069biological_processnegative regulation of programmed cell death
A0070269biological_processpyroptotic inflammatory response
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006508biological_processproteolysis
B0006915biological_processapoptotic process
B0006954biological_processinflammatory response
B0008233molecular_functionpeptidase activity
B0008656molecular_functioncysteine-type endopeptidase activator activity involved in apoptotic process
B0010804biological_processnegative regulation of tumor necrosis factor-mediated signaling pathway
B0012501biological_processprogrammed cell death
B0031665biological_processnegative regulation of lipopolysaccharide-mediated signaling pathway
B0032088biological_processnegative regulation of NF-kappaB transcription factor activity
B0032089molecular_functionNACHT domain binding
B0032691biological_processnegative regulation of interleukin-1 beta production
B0032731biological_processpositive regulation of interleukin-1 beta production
B0032991cellular_componentprotein-containing complex
B0038187molecular_functionpattern recognition receptor activity
B0042803molecular_functionprotein homodimerization activity
B0042981biological_processregulation of apoptotic process
B0043122biological_processregulation of canonical NF-kappaB signal transduction
B0043124biological_processnegative regulation of canonical NF-kappaB signal transduction
B0043280biological_processpositive regulation of cysteine-type endopeptidase activity involved in apoptotic process
B0045087biological_processinnate immune response
B0050700molecular_functionCARD domain binding
B0051607biological_processdefense response to virus
B0061702cellular_componentcanonical inflammasome complex
B0072559cellular_componentNLRP3 inflammasome complex
B0097264biological_processself proteolysis
B0097340biological_processinhibition of cysteine-type endopeptidase activity
B0140374biological_processantiviral innate immune response
B0140608molecular_functioncysteine-type endopeptidase activator activity
B0140633biological_processCARD8 inflammasome complex assembly
B0140634cellular_componentCARD8 inflammasome complex
B0140693molecular_functionmolecular condensate scaffold activity
B1900226biological_processnegative regulation of NLRP3 inflammasome complex assembly
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006508biological_processproteolysis
C0006915biological_processapoptotic process
C0006954biological_processinflammatory response
C0008233molecular_functionpeptidase activity
C0008656molecular_functioncysteine-type endopeptidase activator activity involved in apoptotic process
C0010804biological_processnegative regulation of tumor necrosis factor-mediated signaling pathway
C0012501biological_processprogrammed cell death
C0031665biological_processnegative regulation of lipopolysaccharide-mediated signaling pathway
C0032088biological_processnegative regulation of NF-kappaB transcription factor activity
C0032089molecular_functionNACHT domain binding
C0032691biological_processnegative regulation of interleukin-1 beta production
C0032731biological_processpositive regulation of interleukin-1 beta production
C0032991cellular_componentprotein-containing complex
C0038187molecular_functionpattern recognition receptor activity
C0042803molecular_functionprotein homodimerization activity
C0042981biological_processregulation of apoptotic process
C0043122biological_processregulation of canonical NF-kappaB signal transduction
C0043124biological_processnegative regulation of canonical NF-kappaB signal transduction
C0043280biological_processpositive regulation of cysteine-type endopeptidase activity involved in apoptotic process
C0045087biological_processinnate immune response
C0050700molecular_functionCARD domain binding
C0051607biological_processdefense response to virus
C0061702cellular_componentcanonical inflammasome complex
C0072559cellular_componentNLRP3 inflammasome complex
C0097264biological_processself proteolysis
C0097340biological_processinhibition of cysteine-type endopeptidase activity
C0140374biological_processantiviral innate immune response
C0140608molecular_functioncysteine-type endopeptidase activator activity
C0140633biological_processCARD8 inflammasome complex assembly
C0140634cellular_componentCARD8 inflammasome complex
C0140693molecular_functionmolecular condensate scaffold activity
C1900226biological_processnegative regulation of NLRP3 inflammasome complex assembly
D0004177molecular_functionaminopeptidase activity
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0005874cellular_componentmicrotubule
D0006508biological_processproteolysis
D0008236molecular_functionserine-type peptidase activity
D0008239molecular_functiondipeptidyl-peptidase activity
D0031252cellular_componentcell leading edge
D0042802molecular_functionidentical protein binding
D0043069biological_processnegative regulation of programmed cell death
D0070269biological_processpyroptotic inflammatory response
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsSITE: (Microbial infection) Cleavage; by HIV-1 protease => ECO:0000269|PubMed:33542150
ChainResidueDetails
BPHE59
CPHE59

site_idSWS_FT_FI2
Number of Residues2
DetailsSITE: Cleavage; by autolysis => ECO:0000255|PROSITE-ProRule:PRU01174, ECO:0000269|PubMed:22087307, ECO:0000269|PubMed:32051255, ECO:0000269|PubMed:33542150
ChainResidueDetails
BPHE296
CPHE296
DASP808
DHIS840

site_idSWS_FT_FI3
Number of Residues2
DetailsBINDING: covalent => ECO:0000269|PubMed:33731932, ECO:0000269|PubMed:34019797, ECO:0007744|PDB:6X6C, ECO:0007744|PDB:7JN7
ChainResidueDetails
ASER730
DSER730

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: N-acetylalanine => ECO:0007744|PubMed:19413330
ChainResidueDetails
AALA2
DALA2

222415

PDB entries from 2024-07-10

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