7JN7

Human DPP9-CARD8 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004177	molecular_function	aminopeptidase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005829	cellular_component	cytosol
A	0005874	cellular_component	microtubule
A	0006508	biological_process	proteolysis
A	0008233	molecular_function	peptidase activity
A	0008236	molecular_function	serine-type peptidase activity
A	0008239	molecular_function	dipeptidyl-peptidase activity
A	0016787	molecular_function	hydrolase activity
A	0031252	cellular_component	cell leading edge
A	0042802	molecular_function	identical protein binding
A	0043069	biological_process	negative regulation of programmed cell death
A	0070269	biological_process	pyroptotic inflammatory response
B	0002218	biological_process	activation of innate immune response
B	0002376	biological_process	immune system process
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006508	biological_process	proteolysis
B	0006954	biological_process	inflammatory response
B	0008233	molecular_function	peptidase activity
B	0010804	biological_process	negative regulation of tumor necrosis factor-mediated signaling pathway
B	0012501	biological_process	programmed cell death
B	0016787	molecular_function	hydrolase activity
B	0031648	biological_process	protein destabilization
B	0031665	biological_process	negative regulation of lipopolysaccharide-mediated signaling pathway
B	0032089	molecular_function	NACHT domain binding
B	0032691	biological_process	negative regulation of interleukin-1 beta production
B	0032731	biological_process	positive regulation of interleukin-1 beta production
B	0032991	cellular_component	protein-containing complex
B	0038187	molecular_function	pattern recognition receptor activity
B	0042803	molecular_function	protein homodimerization activity
B	0042981	biological_process	regulation of apoptotic process
B	0043124	biological_process	negative regulation of canonical NF-kappaB signal transduction
B	0045087	biological_process	innate immune response
B	0050700	molecular_function	CARD domain binding
B	0050729	biological_process	positive regulation of inflammatory response
B	0051607	biological_process	defense response to virus
B	0061702	cellular_component	canonical inflammasome complex
B	0072559	cellular_component	NLRP3 inflammasome complex
B	0097193	biological_process	intrinsic apoptotic signaling pathway
B	0097264	biological_process	self proteolysis
B	0140374	biological_process	antiviral innate immune response
B	0140608	molecular_function	cysteine-type endopeptidase activator activity
B	0140633	biological_process	CARD8 inflammasome complex assembly
B	0140634	cellular_component	CARD8 inflammasome complex
B	0140693	molecular_function	molecular condensate scaffold activity
B	1900226	biological_process	negative regulation of NLRP3 inflammasome complex assembly
C	0002218	biological_process	activation of innate immune response
C	0002376	biological_process	immune system process
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006508	biological_process	proteolysis
C	0006954	biological_process	inflammatory response
C	0008233	molecular_function	peptidase activity
C	0010804	biological_process	negative regulation of tumor necrosis factor-mediated signaling pathway
C	0012501	biological_process	programmed cell death
C	0016787	molecular_function	hydrolase activity
C	0031648	biological_process	protein destabilization
C	0031665	biological_process	negative regulation of lipopolysaccharide-mediated signaling pathway
C	0032089	molecular_function	NACHT domain binding
C	0032691	biological_process	negative regulation of interleukin-1 beta production
C	0032731	biological_process	positive regulation of interleukin-1 beta production
C	0032991	cellular_component	protein-containing complex
C	0038187	molecular_function	pattern recognition receptor activity
C	0042803	molecular_function	protein homodimerization activity
C	0042981	biological_process	regulation of apoptotic process
C	0043124	biological_process	negative regulation of canonical NF-kappaB signal transduction
C	0045087	biological_process	innate immune response
C	0050700	molecular_function	CARD domain binding
C	0050729	biological_process	positive regulation of inflammatory response
C	0051607	biological_process	defense response to virus
C	0061702	cellular_component	canonical inflammasome complex
C	0072559	cellular_component	NLRP3 inflammasome complex
C	0097193	biological_process	intrinsic apoptotic signaling pathway
C	0097264	biological_process	self proteolysis
C	0140374	biological_process	antiviral innate immune response
C	0140608	molecular_function	cysteine-type endopeptidase activator activity
C	0140633	biological_process	CARD8 inflammasome complex assembly
C	0140634	cellular_component	CARD8 inflammasome complex
C	0140693	molecular_function	molecular condensate scaffold activity
C	1900226	biological_process	negative regulation of NLRP3 inflammasome complex assembly
D	0004177	molecular_function	aminopeptidase activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005829	cellular_component	cytosol
D	0005874	cellular_component	microtubule
D	0006508	biological_process	proteolysis
D	0008233	molecular_function	peptidase activity
D	0008236	molecular_function	serine-type peptidase activity
D	0008239	molecular_function	dipeptidyl-peptidase activity
D	0016787	molecular_function	hydrolase activity
D	0031252	cellular_component	cell leading edge
D	0042802	molecular_function	identical protein binding
D	0043069	biological_process	negative regulation of programmed cell death
D	0070269	biological_process	pyroptotic inflammatory response

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"30291141","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	4
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"UniProtKB","id":"Q6V1X1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"description":"covalent","evidences":[{"source":"PubMed","id":"33731932","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34019797","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6X6C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7JN7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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