7KEU

Cryo-EM structure of the Caspase-1-CARD:ASC-CARD octamer

Summary for 7KEU

• Entry DOI: 10.2210/pdb7keu/pdb
• EMDB information: 22219 22220 22233
• Descriptor: Caspase-1, Apoptosis-associated speck-like protein containing a CARD (2 entities in total)
• Functional Keywords: asc, apoptosis-associated speck-like protein containing a card, pycard, caspase-1, cryo-em, helical filament, octamer, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 8
• Total formula weight: 77008.62

Authors

Hollingsworth, L.R.,David, L.,Li, Y.,Ruan, J.,Wu, H. (deposition date: 2020-10-12, release date: 2020-11-25, Last modification date: 2024-03-06)

• Primary citation: Robert Hollingsworth, L.,David, L.,Li, Y.,Griswold, A.R.,Ruan, J.,Sharif, H.,Fontana, P.,Orth-He, E.L.,Fu, T.M.,Bachovchin, D.A.,Wu, H.; Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes.; Nat Commun, 12:189-189, 2021; PubMed: 33420033; DOI: 10.1038/s41467-020-20320-y

Experimental method

ELECTRON MICROSCOPY (3.9 Å)