7KEU
Cryo-EM structure of the Caspase-1-CARD:ASC-CARD octamer
Summary for 7KEU
Entry DOI | 10.2210/pdb7keu/pdb |
EMDB information | 22219 22220 22233 |
Descriptor | Caspase-1, Apoptosis-associated speck-like protein containing a CARD (2 entities in total) |
Functional Keywords | asc, apoptosis-associated speck-like protein containing a card, pycard, caspase-1, cryo-em, helical filament, octamer, immune system |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 8 |
Total formula weight | 77008.62 |
Authors | Hollingsworth, L.R.,David, L.,Li, Y.,Ruan, J.,Wu, H. (deposition date: 2020-10-12, release date: 2020-11-25, Last modification date: 2024-03-06) |
Primary citation | Robert Hollingsworth, L.,David, L.,Li, Y.,Griswold, A.R.,Ruan, J.,Sharif, H.,Fontana, P.,Orth-He, E.L.,Fu, T.M.,Bachovchin, D.A.,Wu, H. Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes. Nat Commun, 12:189-189, 2021 Cited by PubMed: 33420033DOI: 10.1038/s41467-020-20320-y PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.9 Å) |
Structure validation
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