7KEU

Cryo-EM structure of the Caspase-1-CARD:ASC-CARD octamer

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (E, F, G, H)	Caspase-1	polymer	85	9719.3	4	UniProt (P29466) Pfam (PF00619)	Homo sapiens (Human)	CASP-1,Interleukin-1 beta convertase,IL-1BC,Interleukin-1 beta-converting enzyme,IL-1 beta-converting enzyme,p45
2	E, F, G, H (A, B, C, D)	Apoptosis-associated speck-like protein containing a CARD	polymer	82	9532.8	4	UniProt (Q9ULZ3) Pfam (PF00619)	Homo sapiens (Human)	hASC,Caspase recruitment domain-containing protein 5,PYD and CARD domain-containing protein,Target of methylation-induced silencing 1

Sequence modifications

E, F, G, H: 2 - 86 (UniProt: P29466)

PDB	External Database	Details
Trp 20	Gly 20	conflict

A, B, C, D: 113 - 194 (UniProt: Q9ULZ3)

PDB	External Database	Details
Gly 169	Trp 169	conflict

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	77008.6
All*	Total formula weight	77008.6

*Water molecules are not included.