7NGA

CryoEM structure of the MDA5-dsRNA filament in complex with ADP with 88-degree helical twist

Summary for 7NGA

• Entry DOI: 10.2210/pdb7nga/pdb
• EMDB information: 11937 12092
• Descriptor: RNA (5'-R(P*UP*CP*CP*AP*UP*GP*CP*GP*CP*AP*UP*GP*AP*CP*G)-3'), RNA (5'-R(P*AP*CP*GP*UP*CP*AP*UP*GP*CP*GP*CP*AP*UP*GP*G)-3'), Interferon-induced helicase C domain-containing protein 1, ... (5 entities in total)
• Functional Keywords: protein-rna complex, helical filament, atpase, innate immune receptor, immune system, antiviral protein
• Biological source: Mus musculus (Mouse); More
• Total number of polymer chains: 3
• Total formula weight: 126192.79

Authors

Yu, Q.,Modis, Y. (deposition date: 2021-02-08, release date: 2021-11-17, Last modification date: 2021-12-01)

• Primary citation: Yu, Q.,Herrero Del Valle, A.,Singh, R.,Modis, Y.; MDA5 disease variant M854K prevents ATP-dependent structural discrimination of viral and cellular RNA.; Nat Commun, 12:6668-6668, 2021; PubMed: 34795277; DOI: 10.1038/s41467-021-27062-5

Experimental method

ELECTRON MICROSCOPY (3.9 Å)