8CZO

Cryo-EM structure of BCL10 CARD - MALT1 DD filament

Summary for 8CZO

• Entry DOI: 10.2210/pdb8czo/pdb
• EMDB information: 27100
• Descriptor: Mucosa-associated lymphoid tissue lymphoma translocation protein 1, B-cell lymphoma/leukemia 10 (2 entities in total)
• Functional Keywords: filament, cbm complex, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 44
• Total formula weight: 511059.01

Authors

David, L.,Wu, H. (deposition date: 2022-05-25, release date: 2022-06-22, Last modification date: 2022-08-17)

• Primary citation: Xia, M.,David, L.,Teater, M.,Gutierrez, J.,Wang, X.,Meydan, C.,Lytle, A.,Slack, G.W.,Scott, D.W.,Morin, R.D.,Onder, O.,Elenitoba-Johnson, K.S.J.,Zamponi, N.,Cerchietti, L.,Lu, T.,Philippar, U.,Fontan, L.,Wu, H.,Melnick, A.M.; BCL10 Mutations Define Distinct Dependencies Guiding Precision Therapy for DLBCL.; Cancer Discov, 12:1922-1941, 2022; PubMed: 35658124; DOI: 10.1158/2159-8290.CD-21-1566

Experimental method

ELECTRON MICROSCOPY (4.3 Å)