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6D3O
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BU of 6d3o by Molmil
Crystal Structure of Vascular Endothelial Growth Factor (VEGF8-109) with HH4, an alpha/beta-Peptide with Irregular Secondary Structure
分子名称: HH4 alpha/beta-Peptide, Vascular endothelial growth factor A
著者Thomas, N.C, Forest, K.T, Gellman, S.H.
登録日2018-04-16
公開日2019-04-24
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献High-Resolution Structures for a Complex Between a Non-Helical Foldamer and VEGF
To Be Published
4ZFF
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BU of 4zff by Molmil
Dual-acting Fab 5A12 in complex with VEGF
分子名称: Fragment antigen binding (Fab) 5A12 Heavy chain, Fragment antigen binding (Fab) 5A12 Light chain, SULFATE ION, ...
著者Harris, S.F, Wu, P.
登録日2015-04-21
公開日2015-07-01
最終更新日2015-09-16
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Deep Sequencing-guided Design of a High Affinity Dual Specificity Antibody to Target Two Angiogenic Factors in Neovascular Age-related Macular Degeneration.
J.Biol.Chem., 290, 2015
4WPB
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BU of 4wpb by Molmil
Vascular endothelial growth factor in complex with alpha/beta-VEGF-1
分子名称: Vascular endothelial growth factor A, alpha/beta-VEGF-1
著者Kreitler, D.F, Checco, J.W, Gellman, S.H, Forest, K.T.
登録日2014-10-17
公開日2015-04-15
最終更新日2024-07-10
実験手法X-RAY DIFFRACTION (3.11 Å)
主引用文献Targeting diverse protein-protein interaction interfaces with alpha / beta-peptides derived from the Z-domain scaffold.
Proc.Natl.Acad.Sci.USA, 112, 2015
1KAT
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BU of 1kat by Molmil
Solution Structure of a Phage-Derived Peptide Antagonist in Complex with Vascular Endothelial Growth Factor
分子名称: Phage-Derived Peptide Antagonist, Vascular Endothelial Growth Factor
著者Pan, B, Li, B, Russell, S.J, Tom, J.Y.K, Cochran, A.G, Fairbrother, W.J.
登録日2001-11-02
公開日2002-11-02
最終更新日2022-02-23
実験手法SOLUTION NMR
主引用文献Solution Structure of a Phage-derived Peptide Antagonist in Complex with Vascular Endothelial Growth Factor
J.Mol.Biol., 316, 2002
1BJ1
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BU of 1bj1 by Molmil
VASCULAR ENDOTHELIAL GROWTH FACTOR IN COMPLEX WITH A NEUTRALIZING ANTIBODY
分子名称: Fab fragment, heavy chain, light chain, ...
著者Muller, Y.A, Christinger, H.W, De Vos, A.M.
登録日1998-06-30
公開日1999-01-13
最終更新日2023-08-02
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献VEGF and the Fab fragment of a humanized neutralizing antibody: crystal structure of the complex at 2.4 A resolution and mutational analysis of the interface.
Structure, 6, 1998
3S1B
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BU of 3s1b by Molmil
The Development of Peptide-based Tools for the Analysis of Angiogenesis
分子名称: Vascular endothelial growth factor A, mini-Z
著者Murray, J.M, Wiesmann, C.
登録日2011-05-14
公開日2011-08-17
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献The development of Peptide-based tools for the analysis of angiogenesis.
Chem.Biol., 18, 2011
3S1K
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BU of 3s1k by Molmil
The Development of Peptide-based Tools for the Analysis of Angiogenesis
分子名称: Vascular endothelial growth factor A, Z-domain
著者Murray, J.M, Wiesmann, C.
登録日2011-05-15
公開日2011-08-17
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献The development of Peptide-based tools for the analysis of angiogenesis.
Chem.Biol., 18, 2011
3P9W
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BU of 3p9w by Molmil
Crystal structure of an engineered human autonomous VH Domain in complex with VEGF
分子名称: Vascular endothelial growth factor A, human VEGF
著者Ma, X, Wiesmann, C.
登録日2010-10-18
公開日2012-04-18
最終更新日2013-06-19
実験手法X-RAY DIFFRACTION (2.41 Å)
主引用文献Design of Synthetic Autonomous VH Domain Libraries and Structural Analysis of a VH Domain Bound to Vascular Endothelial Growth Factor.
J.Mol.Biol., 425, 2013
4QCI
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BU of 4qci by Molmil
PDGF-B blocking antibody bound to PDGF-BB
分子名称: Platelet-derived growth factor subunit B, anti-PDGF-BB antibody - Light Chain, anti-PDGF-BB antibody - Heavy chain
著者Kuai, J, Mosyak, L, Tam, M, LaVallie, E, Pullen, N, Carven, G.
登録日2014-05-12
公開日2015-03-11
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Characterization of Binding Mode of Action of a Blocking Anti-Platelet-Derived Growth Factor (PDGF)-B Monoclonal Antibody, MOR8457, Reveals Conformational Flexibility and Avidity Needed for PDGF-BB To Bind PDGF Receptor-beta.
Biochemistry, 54, 2015
5HHD
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BU of 5hhd by Molmil
Crystal Structure of Chemically Synthesized Heterochiral {RFX037 plus VEGF-A} Protein Complex in space group P21
分子名称: D-Peptide RFX037.D, D-Vascular endothelial growth factor, DI(HYDROXYETHYL)ETHER, ...
著者Uppalapati, M, LEE, D.J, Mandal, K, Kent, S.B.H, Sidhu, S.
登録日2016-01-10
公開日2016-03-09
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献A Potent d-Protein Antagonist of VEGF-A is Nonimmunogenic, Metabolically Stable, and Longer-Circulating in Vivo.
Acs Chem.Biol., 11, 2016
2C7W
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BU of 2c7w by Molmil
Crystal Structure of human vascular endothelial growth factor-B: Identification of amino acids important for angiogeninc activity
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, VASCULAR ENDOTHELIAL GROWTH FACTOR B PRECURSOR
著者Iyer, S, Scotney, P.D, Nash, A.D, Acharya, K.R.
登録日2005-11-29
公開日2007-01-30
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.48 Å)
主引用文献Crystal Structure of Human Vascular Endothelial Growth Factor-B: Identification of Amino Acids Important for Receptor Binding
J.Mol.Biol., 359, 2006
2FJG
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BU of 2fjg by Molmil
Structure of the G6 Fab, a phage derived Fab fragment, in complex with VEGF
分子名称: Fab heavy chain, Fab light chain, SULFATE ION, ...
著者Wiesmann, C.
登録日2006-01-02
公開日2006-02-07
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structure-function studies of two synthetic anti-vascular endothelial growth factor Fabs and comparison with the Avastin Fab.
J.Biol.Chem., 281, 2006
2XV7
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BU of 2xv7 by Molmil
Crystal structure of vascular endothelial growth factor D
分子名称: VASCULAR ENDOTHELIAL GROWTH FACTOR D, alpha-D-mannopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
著者Leppanen, V.-M, Jeltsch, M, Anisimov, A, Tvorogov, D, Aho, K, Kalkkinen, N, Toivanen, P, Yla-Herttuala, S, Ballmer-Hofer, K, Alitalo, K.
登録日2010-10-23
公開日2011-01-12
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structural Determinants of Vascular Endothelial Growth Factor-D - Receptor Binding and Specificity.
Blood, 117, 2011
5HHC
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BU of 5hhc by Molmil
Crystal Structure of Chemically Synthesized Heterochiral {RFX037 plus VEGF-A} Protein Complex in space group P21/n
分子名称: D- Vascular endothelial growth factor-A, GLYCEROL, Vascular endothelial growth factor A
著者Uppalapati, M, Lee, D.J, Mandal, K, Kent, S.B.H, Sidhu, S.
登録日2016-01-10
公開日2016-03-09
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献A Potent d-Protein Antagonist of VEGF-A is Nonimmunogenic, Metabolically Stable, and Longer-Circulating in Vivo.
Acs Chem.Biol., 11, 2016
4GLN
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BU of 4gln by Molmil
Crystal Structure of Chemically Synthesized Heterochiral {D-Protein Antagonist plus VEGF-A} Protein Complex in space group P21/n
分子名称: D-RFX001, Vascular endothelial growth factor A
著者Mandal, K, Uppalapati, M, Ault-Riche, D, Kenney, J, Lowitz, J, Sidhu, S, Kent, S.B.H.
登録日2012-08-14
公開日2012-09-05
最終更新日2019-04-24
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Chemical synthesis and X-ray structure of a heterochiral {D-protein antagonist plus vascular endothelial growth factor} protein complex by racemic crystallography.
Proc.Natl.Acad.Sci.USA, 109, 2012
3BDY
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BU of 3bdy by Molmil
Dual specific bH1 Fab in complex with VEGF
分子名称: Fab Fragment -Heavy Chain, Fab Fragment -Light Chain, GLYCEROL, ...
著者Bostrom, J.M, Wiesmann, C, Appleton, B.A.
登録日2007-11-15
公開日2008-11-18
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Variants of the antibody herceptin that interact with HER2 and VEGF at the antigen binding site
Science, 323, 2009
3QTK
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BU of 3qtk by Molmil
The crystal structure of chemically synthesized VEGF-A
分子名称: ACETATE ION, GLYCEROL, Vascular endothelial growth factor A, ...
著者Mandal, K, Kent, S.B.H.
登録日2011-02-22
公開日2011-07-27
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.849 Å)
主引用文献Total chemical synthesis of biologically active vascular endothelial growth factor.
Angew.Chem.Int.Ed.Engl., 50, 2011
4GLS
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BU of 4gls by Molmil
Crystal Structure of Chemically Synthesized Heterochiral {D-Protein Antagonist plus VEGF-A} Protein Complex in space group P21
分子名称: D- RFX001, D- Vascular endothelial growth factor-A, DI(HYDROXYETHYL)ETHER, ...
著者Mandal, K, Uppalapati, M, Ault-Riche, D, Kenney, J, Lowitz, J, Sidhu, S, Kent, S.B.H.
登録日2012-08-14
公開日2012-09-05
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Chemical synthesis and X-ray structure of a heterochiral {D-protein antagonist plus vascular endothelial growth factor} protein complex by racemic crystallography.
Proc.Natl.Acad.Sci.USA, 109, 2012
5FV2
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BU of 5fv2 by Molmil
Crystal structure of hVEGF in complex with VH domain antibody
分子名称: VASCULAR ENDOTHELIAL GROWTH FACTOR, VH DOMAIN ANTIBODY
著者Chung, C, Batuwangala, T.
登録日2016-02-02
公開日2016-02-17
最終更新日2019-05-15
実験手法X-RAY DIFFRACTION (3.45 Å)
主引用文献Novel Interaction Mechanism of a Domain Antibody Based Inhibitor of Human Vascular Endothelial Growth Factor with Greater Potency Than Ranibizumab and Bevacizumab and Improved Capacity Over Aflibercept.
J.Biol.Chem., 291, 2016
5FV1
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BU of 5fv1 by Molmil
Crystal structure of hVEGF in complex with VK domain antibody
分子名称: VASCULAR ENDOTHELIAL GROWTH FACTOR A, VK DOMAIN ANTIBODY
著者Chung, C, Walker, A.
登録日2016-02-02
公開日2016-02-17
最終更新日2019-05-15
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Novel Interaction Mechanism of a Domain Antibody Based Inhibitor of Human Vascular Endothelial Growth Factor with Greater Potency Than Ranibizumab and Bevacizumab and Improved Capacity Over Aflibercept.
J.Biol.Chem., 291, 2016
2GNN
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BU of 2gnn by Molmil
Crystal Structure of the Orf Virus NZ2 Variant of VEGF-E
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, BENZAMIDINE, ...
著者Prota, A.E, Pieren, M, Wagner, A, Kostrewa, D, Winkler, F.K, Ballmer-Hofer, K.
登録日2006-04-10
公開日2006-05-09
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structure of the Orf virus NZ2 variant of vascular endothelial growth factor-E. Implications for receptor specificity.
J.Biol.Chem., 281, 2006
2FJH
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BU of 2fjh by Molmil
Structure of the B20-4 Fab, a phage derived Fab fragment, in complex with VEGF
分子名称: Fab fragment heavy chain, Fab fragment light chain, Vascular endothelial growth factor A
著者Wiesmann, C.
登録日2006-01-02
公開日2006-02-07
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structure-function studies of two synthetic anti-vascular endothelial growth factor Fabs and comparison with the Avastin Fab.
J.Biol.Chem., 281, 2006
1WQ8
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BU of 1wq8 by Molmil
Crystal structure of Vammin, a VEGF-F from a snake venom
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Vascular endothelial growth factor toxin
著者Suto, K, Yamazaki, Y, Morita, T, Mizuno, H.
登録日2004-09-23
公開日2004-12-07
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal structures of novel vascular endothelial growth factors (VEGF) from snake venoms: insight into selective VEGF binding to kinase insert domain-containing receptor but not to fms-like tyrosine kinase-1.
J.Biol.Chem., 280, 2005
1CZ8
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BU of 1cz8 by Molmil
VASCULAR ENDOTHELIAL GROWTH FACTOR IN COMPLEX WITH AN AFFINITY MATURED ANTIBODY
分子名称: HEAVY CHAIN OF NEUTRALIZING ANTIBODY, LIGHT CHAIN OF NEUTRALIZING ANTIBODY, SULFATE ION, ...
著者Chen, Y, Wiesmann, C, Fuh, G, Li, B, Christinger, H.W, McKay, P, de Vos, A.M, Lowman, H.B.
登録日1999-09-01
公開日2000-03-20
最終更新日2017-04-05
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Selection and analysis of an optimized anti-VEGF antibody: crystal structure of an affinity-matured Fab in complex with antigen.
J.Mol.Biol., 293, 1999
4HQX
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CRYSTAL STRUCTURE OF HUMAN PDGF-BB IN COMPLEX WITH A Modified nucleotide aptamer (SOMAmer SL4)
分子名称: MAGNESIUM ION, Platelet-derived growth factor subunit B, SODIUM ION, ...
著者Davies, D.R, Edwards, T.E, Janjic, N, Gelinas, A.D, Zhang, C, Jarvis, T.C.
登録日2012-10-26
公開日2012-11-21
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Unique motifs and hydrophobic interactions shape the binding of modified DNA ligands to protein targets.
Proc.Natl.Acad.Sci.USA, 109, 2012

 

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