COVID-19特辑

冠状病毒，2020. 由David S. Goodsell @ RCSB PDB原图修改

最近爆发的新型冠状病毒传染病（Novel Coronavirus disease 2019: COVID-19）对全世界的人们都构成了严重威胁。为了尽早了解新病毒（Severe Acute Respiratory Syndrome Coronavirus 2: SARS-CoV-2）以开发出有效的抗病毒药物，已经有很多科研人員开始了相关蛋白结构的研究，并且将所获得的结构数据存储于PDB。 PDBj为用户提供了COVID-19相关数据一览的门户页面，并将于每周三更新当日新发布的相关数据。

有关该病毒蛋白质的解说，请参见下面的“当月的分子”页面。

“所有结构”标签的页面则逐一罗列了所有的结构数据，包括由同一研究组提交的系列数据群。 “代表性结构”标签的页面精选具有相同氨基酸序列的结构数据中的高分辨率数据，不重复选择具同一氨基酸序列的数据，即使该数据可能包含不同配体。 “最新条目”标签内包含本周新更新数据。

Created: 2020-09-03 (last edited: more than 1 year ago)

所有结构 (4476)代表性结构 (1994)最新条目 (17)

7MB9

SARS-CoV-2 Main Protease (Mpro) C145A in Complex with Cleavage Site Nsp10/11 (P6-P1)
Descriptor:	3C-like proteinase, ARG-GLU-PRO-MET-LEU-GLN
Authors:	Lockbaum, G.J, Schiffer, C.A.
Deposit date:	2021-03-31
Release date:	2022-06-22
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (1.81 Å)
Cite:	Defining the substrate envelope of SARS-CoV-2 main protease to predict and avoid drug resistance. Nat Commun, 13, 2022

7T70

Co-crystal structure of SARS-CoV-2 Mpro C145A with substrate peptide 4/5
Descriptor:	3C-like proteinase, DIMETHYL SULFOXIDE, GLYCEROL, ...
Authors:	Shaqra, A.M, Schiffer, C.A.
Deposit date:	2021-12-14
Release date:	2022-06-22
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (2.35 Å)
Cite:	Defining the substrate envelope of SARS-CoV-2 main protease to predict and avoid drug resistance. Nat Commun, 13, 2022

7T8M

Co-crystal structure of SARS-CoV-2 Mpro C145A with substrate peptide 5/6
Descriptor:	3C-like proteinase, DIMETHYL SULFOXIDE, GLYCEROL, ...
Authors:	Shaqra, A.M, Schiffer, C.A.
Deposit date:	2021-12-16
Release date:	2022-06-22
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (1.6 Å)
Cite:	Defining the substrate envelope of SARS-CoV-2 main protease to predict and avoid drug resistance. Nat Commun, 13, 2022

7T8R

Co-crystal structure of SARS-CoV-2 Mpro C145A with substrate peptide 7/8
Descriptor:	1,2-ETHANEDIOL, 3C-like proteinase, GLYCEROL, ...
Authors:	Shaqra, A.M, Schiffer, C.A.
Deposit date:	2021-12-16
Release date:	2022-06-22
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (1.74 Å)
Cite:	Defining the substrate envelope of SARS-CoV-2 main protease to predict and avoid drug resistance. Nat Commun, 13, 2022

7T9Y

Co-crystal structure of SARS-CoV-2 Mpro C145A with substrate peptide 8/9
Descriptor:	3C-like proteinase, GLYCEROL, Nonstructural protein 8/9
Authors:	Shaqra, A.M, Schiffer, C.A.
Deposit date:	2021-12-20
Release date:	2022-06-22
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (2.18 Å)
Cite:	Defining the substrate envelope of SARS-CoV-2 main protease to predict and avoid drug resistance. Nat Commun, 13, 2022

7TA4

Co-crystal structure of SARS-CoV-2 Mpro C145A with substrate peptide 9/10
Descriptor:	3C-like proteinase, Nonstructural protein 9/10
Authors:	Shaqra, A.M, Schiffer, C.A.
Deposit date:	2021-12-20
Release date:	2022-06-22
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (1.78 Å)
Cite:	Defining the substrate envelope of SARS-CoV-2 main protease to predict and avoid drug resistance. Nat Commun, 13, 2022

7TA7

Co-crystal structure of SARS-CoV-2 Mpro C145A with substrate peptide 10/11
Descriptor:	3C-like proteinase, GLYCEROL, Nonstructural protein 10/11
Authors:	Shaqra, A.M, Schiffer, C.A.
Deposit date:	2021-12-20
Release date:	2022-06-22
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (2.28 Å)
Cite:	Defining the substrate envelope of SARS-CoV-2 main protease to predict and avoid drug resistance. Nat Commun, 13, 2022

7TB2

Co-crystal structure of SARS-CoV-2 Mpro C145A with substrate peptide 12/13
Descriptor:	3C-like proteinase, Nonstructural protein 12/13
Authors:	Shaqra, A.M, Schiffer, C.A.
Deposit date:	2021-12-21
Release date:	2022-06-22
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	Defining the substrate envelope of SARS-CoV-2 main protease to predict and avoid drug resistance. Nat Commun, 13, 2022

7TBT

Co-crystal structure of SARS-CoV-2 Mpro C145A with substrate peptide 13/14
Descriptor:	3C-like proteinase, Nonstructural protein 13/14
Authors:	Shaqra, A.M, Schiffer, C.A.
Deposit date:	2021-12-22
Release date:	2022-06-22
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (2.45 Å)
Cite:	Defining the substrate envelope of SARS-CoV-2 main protease to predict and avoid drug resistance. Nat Commun, 13, 2022

7TC4

Co-crystal structure of SARS-CoV-2 Mpro C145A with substrate peptide 15/16
Descriptor:	3C-like proteinase, GLYCEROL, Nonstructural protein 15/16
Authors:	Shaqra, A.M, Schiffer, C.A.
Deposit date:	2021-12-22
Release date:	2022-06-22
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (1.94 Å)
Cite:	Defining the substrate envelope of SARS-CoV-2 main protease to predict and avoid drug resistance. Nat Commun, 13, 2022

7UXZ

Crystal structure of SARS-CoV-2 nucleocapsid protein C-terminal domain complexed with Chicoric acid
Descriptor:	(2R,3R)-2,3-bis{[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy}butanedioic acid, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ...
Authors:	Bezerra, E.H.S, Tonoli, C.C.C, Soprano, A.S, Franchini, K.G, Trivella, D.B.B, Benedetti, C.E.
Deposit date:	2022-05-06
Release date:	2022-06-22
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (1.733 Å)
Cite:	Discovery and structural characterization of chicoric acid as a SARS-CoV-2 nucleocapsid protein ligand and RNA binding disruptor. Sci Rep, 12, 2022

7V61

ACE2 -Targeting Monoclonal Antibody as Potent and Broad-Spectrum Coronavirus Blocker
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3E8, ...
Authors:	Yan, R.H, Zhang, Y.Y, Li, Y.N, Zhou, Q.
Deposit date:	2021-08-18
Release date:	2022-06-22
Method:	ELECTRON MICROSCOPY (3.2 Å)
Cite:	ACE2-targeting monoclonal antibody as potent and broad-spectrum coronavirus blocker. Signal Transduct Target Ther, 6, 2021

7VRW

VAS5 Spike (3 RBD down)
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:	Zhen, C, Wang, X.
Deposit date:	2021-10-25
Release date:	2022-06-22
Method:	ELECTRON MICROSCOPY (3.6 Å)
Cite:	VAS5 Spike (3-RBD down) To Be Published

7WG7

Acidic Omicron Spike Trimer
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ...
Authors:	Cui, Z.
Deposit date:	2021-12-28
Release date:	2022-06-22
Method:	ELECTRON MICROSCOPY (4 Å)
Cite:	Structural and functional characterizations of infectivity and immune evasion of SARS-CoV-2 Omicron. Cell, 185, 2022

7WG8

Delta Spike Trimer(3 RBD Down)
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:	Cui, Z.
Deposit date:	2021-12-28
Release date:	2022-06-22
Method:	ELECTRON MICROSCOPY (3.9 Å)
Cite:	Structural and functional characterizations of infectivity and immune evasion of SARS-CoV-2 Omicron. Cell, 185, 2022

7WG9

Delta Spike Trimer(1 RBD Up)
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:	Cui, Z.
Deposit date:	2021-12-28
Release date:	2022-06-22
Method:	ELECTRON MICROSCOPY (3.5 Å)
Cite:	Structural and functional characterizations of infectivity and immune evasion of SARS-CoV-2 Omicron. Cell, 185, 2022

7WGB

Neutral Omicron Spike Trimer in complex with ACE2
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, ...
Authors:	Cui, Z.
Deposit date:	2021-12-28
Release date:	2022-06-22
Method:	ELECTRON MICROSCOPY (3.5 Å)
Cite:	Structural and functional characterizations of infectivity and immune evasion of SARS-CoV-2 Omicron. Cell, 185, 2022

7WGC

Neutral Omicron Spike Trimer in complex with ACE2.
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, Spike glycoprotein
Authors:	Cui, Z.
Deposit date:	2021-12-28
Release date:	2022-06-22
Last modified:	2022-07-13
Method:	ELECTRON MICROSCOPY (3.6 Å)
Cite:	Structural and functional characterizations of infectivity and immune evasion of SARS-CoV-2 Omicron. Cell, 185, 2022

7WHZ

SARS-CoV-2 spike protein in complex with three human neutralizing antibodies
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, IG c1437_light_IGLV1-40_IGLJ1, IG c934_light_IGKV1-5_IGKJ1, ...
Authors:	Zheng, Q, Li, S, Sun, H, Zheng, Z, Wang, S.
Deposit date:	2022-01-01
Release date:	2022-06-22
Method:	ELECTRON MICROSCOPY (3.42 Å)
Cite:	Three SARS-CoV-2 antibodies provide broad and synergistic neutralization against variants of concern, including Omicron. Cell Rep, 39, 2022

7WR8

Local CryoEM structure of the SARS-CoV-2 S6P(B.1.1.529) in complex with BD55-3152 Fab
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, BD55-3152H, BD55-3152L, ...
Authors:	Du, S, Xiao, J.Y.
Deposit date:	2022-01-26
Release date:	2022-06-22
Last modified:	2022-08-31
Method:	ELECTRON MICROSCOPY (3.5 Å)
Cite:	BA.2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infection. Nature, 608, 2022

8CTK

Cryo-EM structure of SARS-CoV-2 M protein in a lipid nanodisc
Descriptor:	Membrane protein
Authors:	Dolan, K.A, Brohawn, S.G.
Deposit date:	2022-05-15
Release date:	2022-06-22
Last modified:	2024-06-12
Method:	ELECTRON MICROSCOPY (3.52 Å)
Cite:	Structure of SARS-CoV-2 M protein in lipid nanodiscs. Elife, 11, 2022

7F5H

The crystal structure of RBD-Nanobody complex, DL28 (SC4)
Descriptor:	GLYCEROL, Nanobody DL28, PHOSPHATE ION, ...
Authors:	Luo, Z.P, Li, T, Lai, Y, Zhou, Y, Tan, J, Li, D.
Deposit date:	2021-06-22
Release date:	2022-06-29
Last modified:	2023-11-29
Method:	X-RAY DIFFRACTION (3 Å)
Cite:	Structural Characterization of a Neutralizing Nanobody With Broad Activity Against SARS-CoV-2 Variants. Front Microbiol, 13, 2022

7F6Y

Complex Structure of antibody BD-503 and RBD-E484K of COVID-19
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy Chain of BD-503, Light Chain of BD-503, ...
Authors:	Xu, H, Wang, B, Zhao, T.N, Su, X.D.
Deposit date:	2021-06-26
Release date:	2022-06-29
Last modified:	2023-11-29
Method:	X-RAY DIFFRACTION (3 Å)
Cite:	Structure-based analyses of neutralization antibodies interacting with naturally occurring SARS-CoV-2 RBD variants. Cell Res., 31, 2021

7F6Z

Complex Structure of antibody BD-503 and RBD-501Y.V2 of COVID-19
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy Chain of BD-503, Light Chain of BD-503, ...
Authors:	Xu, H, Wang, B, Zhao, T.N, Su, X.D.
Deposit date:	2021-06-26
Release date:	2022-06-29
Last modified:	2023-11-29
Method:	X-RAY DIFFRACTION (3 Å)
Cite:	Structure-based analyses of neutralization antibodies interacting with naturally occurring SARS-CoV-2 RBD variants. Cell Res., 31, 2021

7W1S

Crystal structure of SARS-CoV-2 spike receptor-binding domain in complex with neutralizing nanobody Nb-007
Descriptor:	Nanobody Nb-007, Spike protein S1
Authors:	Yang, J, Lin, S, Sun, H.L, Lu, G.W.
Deposit date:	2021-11-20
Release date:	2022-06-29
Last modified:	2023-11-29
Method:	X-RAY DIFFRACTION (1.997 Å)
Cite:	A Potent Neutralizing Nanobody Targeting the Spike Receptor-Binding Domain of SARS-CoV-2 and the Structural Basis of Its Intimate Binding. Front Immunol, 13, 2022

<34 35 36 37 38 39 404142 43 44 45 46 47 48 49 >

Total results:	1994
Displayed results:	25
Sorted by:	Release date (from oldest)