7UXZ

Crystal structure of SARS-CoV-2 nucleocapsid protein C-terminal domain complexed with Chicoric acid

This is a non-PDB format compatible entry.

Summary for 7UXZ

• Entry DOI: 10.2210/pdb7uxz/pdb
• Descriptor: Nucleoprotein, (2R,3R)-2,3-bis{[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy}butanedioic acid, DI(HYDROXYETHYL)ETHER, ... (7 entities in total)
• Functional Keywords: sars-cov-2, ctd, nucleocapsid, chicoric acid, n protein, rna binding protein, rna binding protein-viral protein complex, rna binding protein/viral protein
• Biological source: Severe acute respiratory syndrome coronavirus 2
• Total number of polymer chains: 6
• Total formula weight: 77901.68

Authors

Bezerra, E.H.S.,Tonoli, C.C.C.,Soprano, A.S.,Franchini, K.G.,Trivella, D.B.B.,Benedetti, C.E. (deposition date: 2022-05-06, release date: 2022-06-22, Last modification date: 2023-10-18)

• Primary citation: Mercaldi, G.F.,Bezerra, E.H.S.,Batista, F.A.H.,Tonoli, C.C.C.,Soprano, A.S.,Shimizu, J.F.,Nagai, A.,da Silva, J.C.,Filho, H.V.R.,do Nascimento Faria, J.,da Cunha, M.G.,Zeri, A.C.M.,Nascimento, A.F.Z.,Proenca-Modena, J.L.,Bajgelman, M.C.,Rocco, S.A.,Lopes-de-Oliveira, P.S.,Cordeiro, A.T.,Bruder, M.,Marques, R.E.,Sforca, M.L.,Franchini, K.G.,Benedetti, C.E.,Figueira, A.C.M.,Trivella, D.B.B.; Discovery and structural characterization of chicoric acid as a SARS-CoV-2 nucleocapsid protein ligand and RNA binding disruptor.; Sci Rep, 12:18500-18500, 2022; PubMed: 36323732; DOI: 10.1038/s41598-022-22576-4

Experimental method

X-RAY DIFFRACTION (1.733 Å)