7TV0

Crystal structure of BRD4 bromodomain 1 in complex with dual-acetylated SARS-CoV-2 E

Summary for 7TV0

• Entry DOI: 10.2210/pdb7tv0/pdb
• Descriptor: Bromodomain-containing protein 4, Envelope small membrane protein (3 entities in total)
• Functional Keywords: brd4, bromodomain, sars-cov-2, covid, envelope protein, e protein, transcription
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 68568.89

Authors

Vann, K.R.,Holt, T.A.,Kutateladze, T.G. (deposition date: 2022-02-03, release date: 2022-07-06, Last modification date: 2023-11-15)

• Primary citation: Vann, K.R.,Acharya, A.,Jang, S.M.,Lachance, C.,Zandian, M.,Holt, T.A.,Smith, A.L.,Pandey, K.,Durden, D.L.,El-Gamal, D.,Cote, J.,Byrareddy, S.N.,Kutateladze, T.G.; Binding of the SARS-CoV-2 envelope E protein to human BRD4 is essential for infection.; Structure, 30:1224-, 2022; PubMed: 35716662; DOI: 10.1016/j.str.2022.05.020

Experimental method

X-RAY DIFFRACTION (2.6 Å)