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신종 코로나바이러스 특집 콘텐츠

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코로나 바이러스
코로나 바이러스, 2020. David S. Goodsell @ RCSB PDB에 의한 오리지널 일러스트를 수정

신종 코로나바이러스 감염증 (Novel Coronavirus disease 2019:COVID-19)의 확산이 세계적으로 매우 큰 문제가 되고 있습니다. 시급히 새로운 바이러스(Severe Acute Respiratory Syndrome Coronavirus 2: SARS-CoV-2)를 이해하고 효과적인 약을 개발하기 위해, 신속하게 구조 생물학 연구가 시작되고 있습니다. PDBj는 사용자의 편의를 도모하기 위해 신종 코로나바이러스의 특집 페이지를 제공하고 있습니다. 매주 수요일에 최신 항목이 추가됩니다.

바이러스 단백질에 관한 해설기사는 아래의 「이달의 분자」 페이지를 참조하십시오.

「전체 엔트리」 탭에는, 모든 PDB ID가 포함되어 있습니다. 이용자가 전체의 독립된 엔트리를 검색하고 싶을 때 사용하실 수 있으며, 동일 저자에 의한 그룹등록의 엔트리도 전부 구별되어 있습니다. 「대표구조」 탭에는, 분해능이 가장 높은 대표구조만을 표지하고 있습니다. 아미노산 서열이 100 % 일치하는 PDB 엔트리의 경우, 다른 리간드를 포함하여도 대표구조에는 제외됩니다. 「최신 엔트리」 탭은, 이번주 공개된 가장 최근의 엔트리 입니다.


Created: 2020-09-03 (last edited: more than 1 year ago)2022-09-02
7UZ5
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BU of 7uz5 by Molmil
Structure of the SARS-CoV-2 S 6P trimer in complex with the mouse antibody Fab fragment, M8a-6
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, M8a-6 Fab heavy chain, M8a-6 Fab light chain, ...
Authors:Fan, C, Bjorkman, P.J.
Deposit date:2022-05-08
Release date:2022-12-07
Last modified:2022-12-28
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Neutralizing monoclonal antibodies elicited by mosaic RBD nanoparticles bind conserved sarbecovirus epitopes.
Immunity, 55, 2022
7UZ6
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BU of 7uz6 by Molmil
Structure of the SARS-CoV-2 S 6P trimer in complex with the mouse antibody Fab fragment, M8a-28
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, M8a-28 Fab heavy chain, M8a-28 Fab light chain, ...
Authors:Fan, C, Bjorkman, P.J.
Deposit date:2022-05-08
Release date:2022-12-07
Last modified:2022-12-28
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Neutralizing monoclonal antibodies elicited by mosaic RBD nanoparticles bind conserved sarbecovirus epitopes.
Immunity, 55, 2022
7UZ7
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BU of 7uz7 by Molmil
Structure of the SARS-CoV-2 S 6P trimer in complex with the mouse antibody Fab fragment, M8a-31
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, M8a-31 Fab heavy chain, ...
Authors:Fan, C, Bjorkman, P.J.
Deposit date:2022-05-08
Release date:2022-12-07
Last modified:2022-12-28
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Neutralizing monoclonal antibodies elicited by mosaic RBD nanoparticles bind conserved sarbecovirus epitopes.
Immunity, 55, 2022
7UZ8
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BU of 7uz8 by Molmil
Structure of the SARS-CoV-2 Omicron BA.1 S 6P trimer in complex with the mouse antibody Fab fragment, M8a-31
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, M8a-31 Fab heavy chain, ...
Authors:Fan, C, Bjorkman, P.J.
Deposit date:2022-05-08
Release date:2022-12-07
Last modified:2022-12-28
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Neutralizing monoclonal antibodies elicited by mosaic RBD nanoparticles bind conserved sarbecovirus epitopes.
Immunity, 55, 2022
7UZ9
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BU of 7uz9 by Molmil
Structure of the SARS-CoV-2 S 6P trimer in complex with the mouse antibody Fab fragment, M8a-34
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, M8a-34 Fab heavy chain, M8a-34 Fab light chain, ...
Authors:Fan, C, Bjorkman, P.J.
Deposit date:2022-05-08
Release date:2022-12-07
Last modified:2022-12-28
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Neutralizing monoclonal antibodies elicited by mosaic RBD nanoparticles bind conserved sarbecovirus epitopes.
Immunity, 55, 2022
7UZA
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BU of 7uza by Molmil
Structure of the SARS-CoV-2 S 6P trimer in complex with the mouse antibody Fab fragment, HSW-1
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, HSW-1 Fab heavy chain, ...
Authors:Fan, C, Bjorkman, P.J.
Deposit date:2022-05-08
Release date:2022-12-07
Last modified:2022-12-28
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Neutralizing monoclonal antibodies elicited by mosaic RBD nanoparticles bind conserved sarbecovirus epitopes.
Immunity, 55, 2022
7UZB
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BU of 7uzb by Molmil
Structure of the SARS-CoV-2 S S1 doamin in complex with the mouse antibody Fab fragment, HSW-2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, HSW-2 Fab heavy chain, HSW-2 Fab light chain, ...
Authors:Fan, C, Bjorkman, P.J.
Deposit date:2022-05-08
Release date:2022-12-07
Last modified:2022-12-28
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Neutralizing monoclonal antibodies elicited by mosaic RBD nanoparticles bind conserved sarbecovirus epitopes.
Immunity, 55, 2022
7VHN
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BU of 7vhn by Molmil
Spike of SARS-CoV-2 spike protein(1 up)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:Wang, X.
Deposit date:2021-09-22
Release date:2022-12-07
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Spike of SARS-CoV-2 spike protein(1 up)
To Be Published
7WVL
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BU of 7wvl by Molmil
Structure of P4A2 Fab in complex with Spike-RBD from SARS-CoV-2
Descriptor: P4A2 Fab Light Chain, P4A2 Fab heavy chain, Spike protein S1
Authors:Narayanan, N, Nair, D.T.
Deposit date:2022-02-10
Release date:2022-12-07
Last modified:2022-12-21
Method:X-RAY DIFFRACTION (3 Å)
Cite:A broadly neutralizing monoclonal antibody overcomes the mutational landscape of emerging SARS-CoV-2 variants of concern.
Plos Pathog., 18, 2022
7X2L
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BU of 7x2l by Molmil
Crystal structure of nanobody 3-2A2-4 with SARS-CoV-2 RBD
Descriptor: Nanobody 3-2A2-4, Spike protein S1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Wang, X.Q, Zhang, L.Q, Ren, Y.F, Li, M.X.
Deposit date:2022-02-25
Release date:2022-12-07
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Broadly neutralizing and protective nanobodies against SARS-CoV-2 Omicron subvariants BA.1, BA.2, and BA.4/5 and diverse sarbecoviruses.
Nat Commun, 13, 2022
7X8W
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BU of 7x8w by Molmil
The SARS-CoV-2 receptor binding domain bound with the Fab fragment of a human neutralizing antibody Ab354
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ab354 heavy chain, Ab354 light chain, ...
Authors:Kamada, K, Shirouzu, M.
Deposit date:2022-03-15
Release date:2022-12-07
Last modified:2022-12-21
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Potent SARS-CoV-2 neutralizing antibodies with therapeutic effects in two animal models.
Iscience, 25, 2022
7X8Y
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BU of 7x8y by Molmil
The SARS-CoV-2 receptor binding domain bound with the Fab fragment of a human neutralizing antibody Ab159
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Ab159 heavy chain, Ab159 light chain, ...
Authors:Kamada, K, Shirouzu, M.
Deposit date:2022-03-15
Release date:2022-12-07
Last modified:2022-12-21
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Potent SARS-CoV-2 neutralizing antibodies with therapeutic effects in two animal models.
Iscience, 25, 2022
7X8Z
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BU of 7x8z by Molmil
The SARS-CoV-2 receptor binding domain bound with the Fab fragment of a human neutralizing antibody Ab188
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Ab188 heavy chain, Ab188 light chain, ...
Authors:Kamada, K, Shirouzu, M.
Deposit date:2022-03-15
Release date:2022-12-07
Last modified:2022-12-21
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Potent SARS-CoV-2 neutralizing antibodies with therapeutic effects in two animal models.
Iscience, 25, 2022
7X90
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BU of 7x90 by Molmil
The SARS-CoV-2 receptor binding domain bound with the Fab fragment of a human neutralizing antibody Ab326
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ab326 heavy chain, Ab326 light chain, ...
Authors:Kamada, K, Shirouzu, M.
Deposit date:2022-03-15
Release date:2022-12-07
Last modified:2022-12-21
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Potent SARS-CoV-2 neutralizing antibodies with therapeutic effects in two animal models.
Iscience, 25, 2022
7X91
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BU of 7x91 by Molmil
The SARS-CoV-2 receptor binding domain bound with an Fv-clasp form of a human neutralizing antibody Ab496
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, An Fv-clasp version of the Ab496 heavy chain, An Fv-clasp version of the Ab496 light chain, ...
Authors:Kamada, K, Shirouzu, M.
Deposit date:2022-03-15
Release date:2022-12-07
Last modified:2022-12-21
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Potent SARS-CoV-2 neutralizing antibodies with therapeutic effects in two animal models.
Iscience, 25, 2022
7X92
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BU of 7x92 by Molmil
The SARS-CoV-2 receptor binding domain bound with the Fab fragment of a human neutralizing antibody Ab445
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ab445 heavy chain, Ab445 light chain, ...
Authors:Kamada, K, Shirouzu, M.
Deposit date:2022-03-15
Release date:2022-12-07
Last modified:2022-12-21
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Potent SARS-CoV-2 neutralizing antibodies with therapeutic effects in two animal models.
Iscience, 25, 2022
7ZV7
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BU of 7zv7 by Molmil
Crystal structure of SARS Cov-2 main protease in complex with an inhibitor 57
Descriptor: 3C-like proteinase nsp5, DIMETHYL SULFOXIDE, inhibitor 57
Authors:Rahimova, R, Di Micco, S, Marquez, J.A.
Deposit date:2022-05-13
Release date:2022-12-07
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.336 Å)
Cite:Rational design of the zonulin inhibitor AT1001 derivatives as potential anti SARS-CoV-2.
Eur.J.Med.Chem., 244, 2022
7ZV8
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BU of 7zv8 by Molmil
Crystal structure of SARS Cov-2 main protease in complex with an inhibitor 58
Descriptor: 3C-like proteinase nsp5, DIMETHYL SULFOXIDE, OCTANOIC ACID (CAPRYLIC ACID), ...
Authors:Rahimova, R, Di Micco, S, Marquez, J.A.
Deposit date:2022-05-13
Release date:2022-12-07
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.937 Å)
Cite:Rational design of the zonulin inhibitor AT1001 derivatives as potential anti SARS-CoV-2.
Eur.J.Med.Chem., 244, 2022
8BSD
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BU of 8bsd by Molmil
SARS-CoV-2 nsp10-16 methyltransferase in complex with tubercidin
Descriptor: '2-(4-AMINO-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-HYDROXYMETHYL-TETRAHYDRO-FURAN-3,4-DIOL, 1,2-ETHANEDIOL, 2'-O-methyltransferase nsp16, ...
Authors:Kremling, V, Oberthuer, D, Sprenger, J.
Deposit date:2022-11-24
Release date:2022-12-07
Last modified:2024-06-19
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal structures of Tubercidin bound to the active site of the SARS-CoV-2 methyltransferase nsp10-16
To Be Published
8DW2
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BU of 8dw2 by Molmil
Cryo-EM structure of SARS-CoV-2 RBD in complex with anti-SARS-CoV-2 DARPin,SR22, and two antibody Fabs, S309 and CR3022
Descriptor: Antibody CR3022 heavy chain, Antibody CR3022 light chain, Antibody S309 heavy chain, ...
Authors:Kwon, Y.D, Gorman, J, Kwong, P.D.
Deposit date:2022-07-30
Release date:2022-12-07
Last modified:2023-03-15
Method:ELECTRON MICROSCOPY (4.11 Å)
Cite:A potent and broad neutralization of SARS-CoV-2 variants of concern by DARPins.
Nat.Chem.Biol., 19, 2023
8DW3
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BU of 8dw3 by Molmil
Cryo-EM structure of SARS-CoV-2 RBD in complex with anti-SARS-CoV-2 DARPin,SR16m, and two antibody Fabs, S309 and CR3022
Descriptor: Anti-SARS-CoV-2 DARPin SR16m, Antibody S309 light chain, Spike protein S1, ...
Authors:Kwon, Y.D, Gorman, J, Kwong, P.D.
Deposit date:2022-07-30
Release date:2022-12-07
Last modified:2023-03-15
Method:ELECTRON MICROSCOPY (4.26 Å)
Cite:A potent and broad neutralization of SARS-CoV-2 variants of concern by DARPins.
Nat.Chem.Biol., 19, 2023
8DW9
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BU of 8dw9 by Molmil
Crystal structure of neutralizing antibody D29 Fab in complex with SARS-CoV-2 spike receptor binding domain (RBD)
Descriptor: D29 Fab light chain, D29 Heavy chain, Spike protein S1
Authors:Reddem, E.R, Shapiro, L.
Deposit date:2022-08-01
Release date:2022-12-07
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (4 Å)
Cite:Structural insights into broadly neutralizing antibodies elicited by hybrid immunity against SARS-CoV-2.
Emerg Microbes Infect, 12, 2023
8DWA
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BU of 8dwa by Molmil
Crystal structure of neutralizing antibody P1D9 Fab in complex with SARS-CoV-2 spike receptor binding domain (RBD)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, P1D9 Heavy chain, P1D9 Light chain, ...
Authors:Reddem, E.R, Shapiro, L.
Deposit date:2022-08-01
Release date:2022-12-07
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural insights into broadly neutralizing antibodies elicited by hybrid immunity against SARS-CoV-2.
Emerg Microbes Infect, 12, 2023
8DXS
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BU of 8dxs by Molmil
Cryo-EM structure of RBD-directed neutralizing antibody P2B4 in complex with prefusion SARS-CoV-2 spike glycoprotein
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, P2B4 Heavy chain, P2B4 Light chain, ...
Authors:Reddem, E.R, Shapiro, L.
Deposit date:2022-08-03
Release date:2022-12-07
Last modified:2023-01-18
Method:ELECTRON MICROSCOPY (3.76 Å)
Cite:Structural insights into broadly neutralizing antibodies elicited by hybrid immunity against SARS-CoV-2.
Emerg Microbes Infect, 12, 2023
8EY2
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BU of 8ey2 by Molmil
Cryo-EM structure of SARS-CoV-2 Main protease C145S in complex with N-terminal peptide
Descriptor: 3C-like proteinase
Authors:Noske, G.D, Song, Y, Fernandes, R.S, Oliva, G, Godoy, A.S.
Deposit date:2022-10-26
Release date:2022-12-07
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:An in-solution snapshot of SARS-COV-2 main protease maturation process and inhibition.
Nat Commun, 14, 2023

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