8DW3
Cryo-EM structure of SARS-CoV-2 RBD in complex with anti-SARS-CoV-2 DARPin,SR16m, and two antibody Fabs, S309 and CR3022
Summary for 8DW3
Entry DOI | 10.2210/pdb8dw3/pdb |
EMDB information | 27749 27750 |
Descriptor | Anti-SARS-CoV-2 DARPin SR16m, Spike protein S1, Antibody S309 light chain, ... (7 entities in total) |
Functional Keywords | darpins, anti-sars-cov-2, therapeutics, covid-19, viral protein-immune system complex, viral protein/immune system |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 6 |
Total formula weight | 134930.74 |
Authors | Kwon, Y.D.,Gorman, J.,Kwong, P.D. (deposition date: 2022-07-30, release date: 2022-12-07, Last modification date: 2023-03-15) |
Primary citation | Chonira, V.,Kwon, Y.D.,Gorman, J.,Case, J.B.,Ku, Z.,Simeon, R.,Casner, R.G.,Harris, D.R.,Olia, A.S.,Stephens, T.,Shapiro, L.,Bender, M.F.,Boyd, H.,Teng, I.T.,Tsybovsky, Y.,Krammer, F.,Zhang, N.,Diamond, M.S.,Kwong, P.D.,An, Z.,Chen, Z. A potent and broad neutralization of SARS-CoV-2 variants of concern by DARPins. Nat.Chem.Biol., 19:284-291, 2023 Cited by PubMed: 36411391DOI: 10.1038/s41589-022-01193-2 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (4.26 Å) |
Structure validation
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