7X91

The SARS-CoV-2 receptor binding domain bound with an Fv-clasp form of a human neutralizing antibody Ab496

Summary for 7X91

Entry DOI	10.2210/pdb7x91/pdb
EMDB information	33063
Descriptor	Spike glycoprotein, An Fv-clasp version of the Ab496 heavy chain, An Fv-clasp version of the Ab496 light chain, ... (4 entities in total)
Functional Keywords	severe acute respiratory syndrome coronavirus-2 (sars-cov-2) spike trimer, covid-19, human neutralizing antibody, rbd, viral protein
Biological source	Severe acute respiratory syndrome coronavirus 2 More
Total number of polymer chains	3
Total formula weight	186196.33
Authors	Kamada, K.,Shirouzu, M. (deposition date: 2022-03-15, release date: 2022-12-07, Last modification date: 2022-12-21)
Primary citation	Takeshita, M.,Fukuyama, H.,Kamada, K.,Matsumoto, T.,Makino-Okamura, C.,Uchikubo-Kamo, T.,Tomabechi, Y.,Hanada, K.,Moriyama, S.,Takahashi, Y.,Ishigaki, H.,Nakayama, M.,Nguyen, C.T.,Kitagawa, Y.,Itoh, Y.,Imai, M.,Maemura, T.,Furusawa, Y.,Ueki, H.,Iwatsuki-Horimoto, K.,Ito, M.,Yamayoshi, S.,Kawaoka, Y.,Shirouzu, M.,Ishii, M.,Saya, H.,Kondo, Y.,Kaneko, Y.,Suzuki, K.,Fukunaga, K.,Takeuchi, T. Potent SARS-CoV-2 neutralizing antibodies with therapeutic effects in two animal models. Iscience, 25:105596-105596, 2022 Cited by PubMed: 36406861 DOI: 10.1016/j.isci.2022.105596 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (4.3 Å)

Structure validation