8DW2

Cryo-EM structure of SARS-CoV-2 RBD in complex with anti-SARS-CoV-2 DARPin,SR22, and two antibody Fabs, S309 and CR3022

Summary for 8DW2

• Entry DOI: 10.2210/pdb8dw2/pdb
• EMDB information: 27749 27750
• Descriptor: SR22, Spike protein S1, Antibody S309 light chain, ... (7 entities in total)
• Functional Keywords: darpins, anti-sars-cov-2, therapeutics, covid-19, viral protein-immune system complex, viral protein/immune system
• Biological source: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2); More
• Total number of polymer chains: 6
• Total formula weight: 134566.26

Authors

Kwon, Y.D.,Gorman, J.,Kwong, P.D. (deposition date: 2022-07-30, release date: 2022-12-07, Last modification date: 2023-03-15)

• Primary citation: Chonira, V.,Kwon, Y.D.,Gorman, J.,Case, J.B.,Ku, Z.,Simeon, R.,Casner, R.G.,Harris, D.R.,Olia, A.S.,Stephens, T.,Shapiro, L.,Bender, M.F.,Boyd, H.,Teng, I.T.,Tsybovsky, Y.,Krammer, F.,Zhang, N.,Diamond, M.S.,Kwong, P.D.,An, Z.,Chen, Z.; A potent and broad neutralization of SARS-CoV-2 variants of concern by DARPins.; Nat.Chem.Biol., 19:284-291, 2023; PubMed: 36411391; DOI: 10.1038/s41589-022-01193-2

Experimental method

ELECTRON MICROSCOPY (4.11 Å)