8DW9

Crystal structure of neutralizing antibody D29 Fab in complex with SARS-CoV-2 spike receptor binding domain (RBD)

Summary for 8DW9

Entry DOI	10.2210/pdb8dw9/pdb
Descriptor	Spike protein S1, D29 Heavy chain, D29 Fab light chain (3 entities in total)
Functional Keywords	covid-19, sarbecovirus, wiv1 rbd, viral protein, spike glycoprotein, receptor binding protein, neutralizing antibody, potent, 10-40, fab, viral protein-immune system complex, viral protein/immune system
Biological source	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2) More
Total number of polymer chains	6
Total formula weight	135949.96
Authors	Reddem, E.R.,Shapiro, L. (deposition date: 2022-08-01, release date: 2022-12-07, Last modification date: 2023-10-25)
Primary citation	Luo, M.,Zhou, B.,Reddem, E.R.,Tang, B.,Chen, B.,Zhou, R.,Liu, H.,Liu, L.,Katsamba, P.S.,Au, K.K.,Man, H.O.,To, K.K.,Yuen, K.Y.,Shapiro, L.,Dang, S.,Ho, D.D.,Chen, Z. Structural insights into broadly neutralizing antibodies elicited by hybrid immunity against SARS-CoV-2. Emerg Microbes Infect, 12:2146538-2146538, 2023 Cited by PubMed: 36354024 DOI: 10.1080/22221751.2022.2146538 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (4 Å)

Structure validation