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新型コロナウイルスの構造情報

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コロナウイルス
コロナウイルス, 2020. David S. Goodsell@RCSB PDB による原画を修正

最近、新型コロナウイルス感染症(Novel Coronavirus disease 2019: COVID-19)の拡大が世界中で深刻な問題となっています。早急にこの新型ウイルス(Severe Acute Respiratory Syndrome Coronavirus 2: SARS-CoV-2)を理解し有効な薬を開発するため,関連するタンパク質の構造研究は既に始まっています。そして,解明された構造はPDBに登録されていっています。PDBjでは利用者の利便を図るため,新型コロナウイルス特集ページを作成しました。新たなエントリーが毎週水曜日の週次更新で公開されると、同時にこのページにも追加されます。

またこのウイルスのタンパク質に関する解説記事を以下の「今月の分子」ページに掲載しています。

「全エントリー」のタブでは,同じ著者によるグループ登録のエントリーも全て区別し,すべてのPDB IDを省略せず表示しています。 「代表構造」タブには最も分解能の高い代表構造のみを表示しており,アミノ酸配列が100%同じPDBエントリーはリガンドが異なるものも含め除外してあります。 「最新のエントリー」のタブは,今週公開された最も新しいエントリーです。


作成日: 2020-09-03 (最終更新日: more than 1 year ago)2022-09-02
7T8R
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BU of 7t8r by Molmil
Co-crystal structure of SARS-CoV-2 Mpro C145A with substrate peptide 7/8
分子名称: 1,2-ETHANEDIOL, 3C-like proteinase, GLYCEROL, ...
著者Shaqra, A.M, Schiffer, C.A.
登録日2021-12-16
公開日2022-06-22
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.74 Å)
主引用文献Defining the substrate envelope of SARS-CoV-2 main protease to predict and avoid drug resistance.
Nat Commun, 13, 2022
7T9Y
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BU of 7t9y by Molmil
Co-crystal structure of SARS-CoV-2 Mpro C145A with substrate peptide 8/9
分子名称: 3C-like proteinase, GLYCEROL, Nonstructural protein 8/9
著者Shaqra, A.M, Schiffer, C.A.
登録日2021-12-20
公開日2022-06-22
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.18 Å)
主引用文献Defining the substrate envelope of SARS-CoV-2 main protease to predict and avoid drug resistance.
Nat Commun, 13, 2022
7TA4
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BU of 7ta4 by Molmil
Co-crystal structure of SARS-CoV-2 Mpro C145A with substrate peptide 9/10
分子名称: 3C-like proteinase, Nonstructural protein 9/10
著者Shaqra, A.M, Schiffer, C.A.
登録日2021-12-20
公開日2022-06-22
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.78 Å)
主引用文献Defining the substrate envelope of SARS-CoV-2 main protease to predict and avoid drug resistance.
Nat Commun, 13, 2022
7TA7
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BU of 7ta7 by Molmil
Co-crystal structure of SARS-CoV-2 Mpro C145A with substrate peptide 10/11
分子名称: 3C-like proteinase, GLYCEROL, Nonstructural protein 10/11
著者Shaqra, A.M, Schiffer, C.A.
登録日2021-12-20
公開日2022-06-22
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.28 Å)
主引用文献Defining the substrate envelope of SARS-CoV-2 main protease to predict and avoid drug resistance.
Nat Commun, 13, 2022
7TB2
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BU of 7tb2 by Molmil
Co-crystal structure of SARS-CoV-2 Mpro C145A with substrate peptide 12/13
分子名称: 3C-like proteinase, Nonstructural protein 12/13
著者Shaqra, A.M, Schiffer, C.A.
登録日2021-12-21
公開日2022-06-22
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Defining the substrate envelope of SARS-CoV-2 main protease to predict and avoid drug resistance.
Nat Commun, 13, 2022
7TBT
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BU of 7tbt by Molmil
Co-crystal structure of SARS-CoV-2 Mpro C145A with substrate peptide 13/14
分子名称: 3C-like proteinase, Nonstructural protein 13/14
著者Shaqra, A.M, Schiffer, C.A.
登録日2021-12-22
公開日2022-06-22
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Defining the substrate envelope of SARS-CoV-2 main protease to predict and avoid drug resistance.
Nat Commun, 13, 2022
7TC4
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BU of 7tc4 by Molmil
Co-crystal structure of SARS-CoV-2 Mpro C145A with substrate peptide 15/16
分子名称: 3C-like proteinase, GLYCEROL, Nonstructural protein 15/16
著者Shaqra, A.M, Schiffer, C.A.
登録日2021-12-22
公開日2022-06-22
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.94 Å)
主引用文献Defining the substrate envelope of SARS-CoV-2 main protease to predict and avoid drug resistance.
Nat Commun, 13, 2022
7UXZ
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BU of 7uxz by Molmil
Crystal structure of SARS-CoV-2 nucleocapsid protein C-terminal domain complexed with Chicoric acid
分子名称: (2R,3R)-2,3-bis{[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy}butanedioic acid, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ...
著者Bezerra, E.H.S, Tonoli, C.C.C, Soprano, A.S, Franchini, K.G, Trivella, D.B.B, Benedetti, C.E.
登録日2022-05-06
公開日2022-06-22
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.733 Å)
主引用文献Discovery and structural characterization of chicoric acid as a SARS-CoV-2 nucleocapsid protein ligand and RNA binding disruptor.
Sci Rep, 12, 2022
7V61
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ACE2 -Targeting Monoclonal Antibody as Potent and Broad-Spectrum Coronavirus Blocker
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3E8, ...
著者Yan, R.H, Zhang, Y.Y, Li, Y.N, Zhou, Q.
登録日2021-08-18
公開日2022-06-22
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献ACE2-targeting monoclonal antibody as potent and broad-spectrum coronavirus blocker.
Signal Transduct Target Ther, 6, 2021
7VRW
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BU of 7vrw by Molmil
VAS5 Spike (3 RBD down)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
著者Zhen, C, Wang, X.
登録日2021-10-25
公開日2022-06-22
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献VAS5 Spike (3-RBD down)
To Be Published
7WG7
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BU of 7wg7 by Molmil
Acidic Omicron Spike Trimer
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ...
著者Cui, Z.
登録日2021-12-28
公開日2022-06-22
実験手法ELECTRON MICROSCOPY (4 Å)
主引用文献Structural and functional characterizations of infectivity and immune evasion of SARS-CoV-2 Omicron.
Cell, 185, 2022
7WG8
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Delta Spike Trimer(3 RBD Down)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
著者Cui, Z.
登録日2021-12-28
公開日2022-06-22
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献Structural and functional characterizations of infectivity and immune evasion of SARS-CoV-2 Omicron.
Cell, 185, 2022
7WG9
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BU of 7wg9 by Molmil
Delta Spike Trimer(1 RBD Up)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
著者Cui, Z.
登録日2021-12-28
公開日2022-06-22
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Structural and functional characterizations of infectivity and immune evasion of SARS-CoV-2 Omicron.
Cell, 185, 2022
7WGB
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BU of 7wgb by Molmil
Neutral Omicron Spike Trimer in complex with ACE2
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, ...
著者Cui, Z.
登録日2021-12-28
公開日2022-06-22
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Structural and functional characterizations of infectivity and immune evasion of SARS-CoV-2 Omicron.
Cell, 185, 2022
7WGC
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BU of 7wgc by Molmil
Neutral Omicron Spike Trimer in complex with ACE2.
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, Spike glycoprotein
著者Cui, Z.
登録日2021-12-28
公開日2022-06-22
最終更新日2022-07-13
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献Structural and functional characterizations of infectivity and immune evasion of SARS-CoV-2 Omicron.
Cell, 185, 2022
7WHZ
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BU of 7whz by Molmil
SARS-CoV-2 spike protein in complex with three human neutralizing antibodies
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, IG c1437_light_IGLV1-40_IGLJ1, IG c934_light_IGKV1-5_IGKJ1, ...
著者Zheng, Q, Li, S, Sun, H, Zheng, Z, Wang, S.
登録日2022-01-01
公開日2022-06-22
実験手法ELECTRON MICROSCOPY (3.42 Å)
主引用文献Three SARS-CoV-2 antibodies provide broad and synergistic neutralization against variants of concern, including Omicron.
Cell Rep, 39, 2022
7WR8
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BU of 7wr8 by Molmil
Local CryoEM structure of the SARS-CoV-2 S6P(B.1.1.529) in complex with BD55-3152 Fab
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, BD55-3152H, BD55-3152L, ...
著者Du, S, Xiao, J.Y.
登録日2022-01-26
公開日2022-06-22
最終更新日2022-08-31
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献BA.2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infection.
Nature, 608, 2022
8CTK
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BU of 8ctk by Molmil
Cryo-EM structure of SARS-CoV-2 M protein in a lipid nanodisc
分子名称: Membrane protein
著者Dolan, K.A, Brohawn, S.G.
登録日2022-05-15
公開日2022-06-22
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (3.52 Å)
主引用文献Structure of SARS-CoV-2 M protein in lipid nanodiscs.
Elife, 11, 2022
7F5H
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BU of 7f5h by Molmil
The crystal structure of RBD-Nanobody complex, DL28 (SC4)
分子名称: GLYCEROL, Nanobody DL28, PHOSPHATE ION, ...
著者Luo, Z.P, Li, T, Lai, Y, Zhou, Y, Tan, J, Li, D.
登録日2021-06-22
公開日2022-06-29
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structural Characterization of a Neutralizing Nanobody With Broad Activity Against SARS-CoV-2 Variants.
Front Microbiol, 13, 2022
7F6Y
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BU of 7f6y by Molmil
Complex Structure of antibody BD-503 and RBD-E484K of COVID-19
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy Chain of BD-503, Light Chain of BD-503, ...
著者Xu, H, Wang, B, Zhao, T.N, Su, X.D.
登録日2021-06-26
公開日2022-06-29
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structure-based analyses of neutralization antibodies interacting with naturally occurring SARS-CoV-2 RBD variants.
Cell Res., 31, 2021
7F6Z
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BU of 7f6z by Molmil
Complex Structure of antibody BD-503 and RBD-501Y.V2 of COVID-19
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy Chain of BD-503, Light Chain of BD-503, ...
著者Xu, H, Wang, B, Zhao, T.N, Su, X.D.
登録日2021-06-26
公開日2022-06-29
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structure-based analyses of neutralization antibodies interacting with naturally occurring SARS-CoV-2 RBD variants.
Cell Res., 31, 2021
7W1S
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BU of 7w1s by Molmil
Crystal structure of SARS-CoV-2 spike receptor-binding domain in complex with neutralizing nanobody Nb-007
分子名称: Nanobody Nb-007, Spike protein S1
著者Yang, J, Lin, S, Sun, H.L, Lu, G.W.
登録日2021-11-20
公開日2022-06-29
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.997 Å)
主引用文献A Potent Neutralizing Nanobody Targeting the Spike Receptor-Binding Domain of SARS-CoV-2 and the Structural Basis of Its Intimate Binding.
Front Immunol, 13, 2022
7XH8
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BU of 7xh8 by Molmil
The structure of ZCB11 Fab against SARS-CoV-2 Omicron Spike
分子名称: Spike glycoprotein, The heavy chain of ZCB11 antibody, The light chain of ZCB11 antibody
著者Hang, L, Dang, S.
登録日2022-04-07
公開日2022-06-29
最終更新日2024-07-03
実験手法ELECTRON MICROSCOPY (2.99 Å)
主引用文献A broadly neutralizing antibody protects Syrian hamsters against SARS-CoV-2 Omicron challenge.
Nat Commun, 13, 2022
7XXK
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BU of 7xxk by Molmil
Crystal structure of SARS-CoV-2 N-CTD in complex with GMP
分子名称: CHLORIDE ION, GUANINE, GUANOSINE, ...
著者Zhou, R.J, Ni, X.C, Lei, J.
登録日2022-05-30
公開日2022-06-29
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structure of SARS-CoV-2 N-CTD in complex with GMP
To Be Published
7ZFA
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BU of 7zfa by Molmil
SARS-CoV-2 Omicron RBD in complex with Omi-6 and COVOX-150 Fabs
分子名称: COVOX-150 heavy chain, COVOX-150 light chain, Omi-6 heavy chain, ...
著者Zhou, D, Huo, J, Ren, J, Stuart, D.I.
登録日2022-04-01
公開日2022-06-29
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (4.24 Å)
主引用文献Potent cross-reactive antibodies following Omicron breakthrough in vaccinees.
Cell, 185, 2022

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件を2024-07-17に公開中

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