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新型コロナウイルスの構造情報

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コロナウイルス
コロナウイルス, 2020. David S. Goodsell@RCSB PDB による原画を修正

最近、新型コロナウイルス感染症(Novel Coronavirus disease 2019: COVID-19)の拡大が世界中で深刻な問題となっています。早急にこの新型ウイルス(Severe Acute Respiratory Syndrome Coronavirus 2: SARS-CoV-2)を理解し有効な薬を開発するため,関連するタンパク質の構造研究は既に始まっています。そして,解明された構造はPDBに登録されていっています。PDBjでは利用者の利便を図るため,新型コロナウイルス特集ページを作成しました。新たなエントリーが毎週水曜日の週次更新で公開されると、同時にこのページにも追加されます。

またこのウイルスのタンパク質に関する解説記事を以下の「今月の分子」ページに掲載しています。

「全エントリー」のタブでは,同じ著者によるグループ登録のエントリーも全て区別し,すべてのPDB IDを省略せず表示しています。 「代表構造」タブには最も分解能の高い代表構造のみを表示しており,アミノ酸配列が100%同じPDBエントリーはリガンドが異なるものも含め除外してあります。 「最新のエントリー」のタブは,今週公開された最も新しいエントリーです。


作成日: 2020-09-03 (最終更新日: more than 1 year ago)2022-09-02
7C8V
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BU of 7c8v by Molmil
Structure of sybody SR4 in complex with the SARS-CoV-2 S Receptor Binding domain (RBD)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Spike protein S1, ...
著者Li, T, Yao, H, Cai, H, Qin, W, Li, D.
登録日2020-06-03
公開日2020-06-24
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献A synthetic nanobody targeting RBD protects hamsters from SARS-CoV-2 infection.
Nat Commun, 12, 2021
7C8W
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BU of 7c8w by Molmil
Structure of sybody MR17 in complex with the SARS-CoV-2 S receptor-binding domain (RBD)
分子名称: GLYCEROL, Spike protein S1, Synthetic nanobody MR17, ...
著者Li, T, Cai, H, Yao, H, Qin, W, Li, D.
登録日2020-06-03
公開日2020-06-24
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.77 Å)
主引用文献A synthetic nanobody targeting RBD protects hamsters from SARS-CoV-2 infection.
Nat Commun, 12, 2021
7CAN
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BU of 7can by Molmil
Structure of sybody MR17-K99Y in complex with the SARS-CoV-2 S Receptor-binding domain (RBD)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Spike protein S1, ...
著者Li, T, Yao, H, Cai, H, Qin, W, Li, D.
登録日2020-06-09
公開日2020-06-24
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.94 Å)
主引用文献A synthetic nanobody targeting RBD protects hamsters from SARS-CoV-2 infection.
Nat Commun, 12, 2021
6XCM
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BU of 6xcm by Molmil
Structure of the SARS-CoV-2 spike glycoprotein in complex with the C105 neutralizing antibody Fab fragment (state 1)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Barnes, C.O, Bjorkman, P.J.
登録日2020-06-08
公開日2020-07-01
最終更新日2020-09-02
実験手法ELECTRON MICROSCOPY (3.42 Å)
主引用文献Structures of Human Antibodies Bound to SARS-CoV-2 Spike Reveal Common Epitopes and Recurrent Features of Antibodies.
Cell, 182, 2020
6XE1
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BU of 6xe1 by Molmil
Structure of SARS-CoV-2 spike protein receptor binding domain in complex with a potent neutralizing antibody, CV30 Fab
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CV30 Fab Heavy chain, CV30 Fab Kappa chain, ...
著者Hurlburt, N.K, Pancera, M.
登録日2020-06-11
公開日2020-07-01
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Structural basis for potent neutralization of SARS-CoV-2 and role of antibody affinity maturation.
Nat Commun, 11, 2020
6XIP
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BU of 6xip by Molmil
The 1.5 A Crystal Structure of the Co-factor Complex of NSP7 and the C-terminal Domain of NSP8 from SARS CoV-2
分子名称: 1,2-ETHANEDIOL, Non-structural protein 7, Non-structural protein 8
著者Wilamowski, M, Kim, Y, Jedrzejczak, R, Maltseva, N, Endres, M, Godzik, A, Michalska, K, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID)
登録日2020-06-20
公開日2020-07-01
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Transient and stabilized complexes of Nsp7, Nsp8, and Nsp12 in SARS-CoV-2 replication.
Biophys.J., 120, 2021
6Z97
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BU of 6z97 by Molmil
Structure of the prefusion SARS-CoV-2 spike glycoprotein
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein,Fibritin
著者Duyvesteyn, H.M.E, Ren, J, Zhao, Y, Zhou, D, Huo, J, Carrique, L, Malinauskas, T, Ruza, R.R, Shah, P.N.M, Fry, E.E, Owens, R, Stuart, D.I.
登録日2020-06-03
公開日2020-07-01
最終更新日2020-09-23
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Neutralization of SARS-CoV-2 by Destruction of the Prefusion Spike.
Cell Host Microbe, 28, 2020
6ZCO
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BU of 6zco by Molmil
Crystal Structure of C-terminal Dimerization Domain of Nucleocapsid Phosphoprotein from SARS-CoV-2, crystal form II
分子名称: Nucleoprotein
著者Zinzula, L, Basquin, J, Nagy, I, Bracher, A.
登録日2020-06-11
公開日2020-07-01
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.361 Å)
主引用文献High-resolution structure and biophysical characterization of the nucleocapsid phosphoprotein dimerization domain from the Covid-19 severe acute respiratory syndrome coronavirus 2.
Biochem.Biophys.Res.Commun., 538, 2021
6ZDH
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BU of 6zdh by Molmil
SARS-CoV-2 Spike glycoprotein in complex with a neutralizing antibody EY6A Fab
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, EY6A heavy chain, ...
著者Duyvesteyn, H.M.E, Zhou, D, Zhao, Y, Fry, E.E, Ren, J, Stuart, D.I.
登録日2020-06-14
公開日2020-07-01
最終更新日2021-12-22
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献Structural basis for the neutralization of SARS-CoV-2 by an antibody from a convalescent patient.
Nat.Struct.Mol.Biol., 27, 2020
6ZGE
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BU of 6zge by Molmil
Uncleavable Spike Protein of SARS-CoV-2 in Closed Conformation
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
著者Wrobel, A.G, Benton, D.J, Rosenthal, P.B, Gamblin, S.J.
登録日2020-06-18
公開日2020-07-01
最終更新日2020-09-16
実験手法ELECTRON MICROSCOPY (2.6 Å)
主引用文献SARS-CoV-2 and bat RaTG13 spike glycoprotein structures inform on virus evolution and furin-cleavage effects.
Nat.Struct.Mol.Biol., 27, 2020
6ZGI
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BU of 6zgi by Molmil
Furin Cleaved Spike Protein of SARS-CoV-2 in Closed Conformation
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
著者Wrobel, A.G, Benton, D.J, Rosenthal, P.B, Gamblin, S.J.
登録日2020-06-18
公開日2020-07-01
最終更新日2020-09-16
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献SARS-CoV-2 and bat RaTG13 spike glycoprotein structures inform on virus evolution and furin-cleavage effects.
Nat.Struct.Mol.Biol., 27, 2020
7C2L
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BU of 7c2l by Molmil
S protein of SARS-CoV-2 in complex bound with 4A8
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Yan, R.H, Zhang, Y.Y, Guo, Y.Y, Li, Y.N, Xia, L, Zhou, Q.
登録日2020-05-08
公開日2020-07-01
最終更新日2021-02-17
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献A neutralizing human antibody binds to the N-terminal domain of the Spike protein of SARS-CoV-2.
Science, 369, 2020
6XC2
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BU of 6xc2 by Molmil
Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody CC12.1
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CC12.1 heavy chain, CC12.1 light chain, ...
著者Yuan, M, Liu, H, Wu, N.C, Zhu, X, Wilson, I.A.
登録日2020-06-08
公開日2020-07-08
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.112 Å)
主引用文献Structural basis of a shared antibody response to SARS-CoV-2.
Science, 369, 2020
6XC3
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BU of 6xc3 by Molmil
Crystal structure of SARS-CoV-2 receptor binding domain in complex with antibodies CC12.1 and CR3022
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CC12.1 heavy chain, CC12.1 light chain, ...
著者Yuan, M, Liu, H, Wu, N.C, Zhu, X, Wilson, I.A.
登録日2020-06-08
公開日2020-07-08
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.698 Å)
主引用文献Structural basis of a shared antibody response to SARS-CoV-2.
Science, 369, 2020
6XC4
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BU of 6xc4 by Molmil
Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody CC12.3
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CC12.3 heavy chain, CC12.3 light chain, ...
著者Yuan, M, Liu, H, Wu, N.C, Zhu, X, Wilson, I.A.
登録日2020-06-08
公開日2020-07-08
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.341 Å)
主引用文献Structural basis of a shared antibody response to SARS-CoV-2.
Science, 369, 2020
6XC7
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BU of 6xc7 by Molmil
Crystal structure of SARS-CoV-2 receptor binding domain in complex with antibodies CC12.3 and CR3022
分子名称: CC12.3 heavy chain, CC12.3 light chain, CR3022 heavy chain, ...
著者Yuan, M, Liu, H, Wu, N.C, Zhu, X, Wilson, I.A.
登録日2020-06-08
公開日2020-07-08
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.883 Å)
主引用文献Structural basis of a shared antibody response to SARS-CoV-2.
Science, 369, 2020
6ZFO
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BU of 6zfo by Molmil
Association of two complexes of largely structurally disordered Spike ectodomain with bound EY6A Fab
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, EY6A heavy chain, EY6A light chain, ...
著者Duyvesteyn, H.M.E, Zhou, D, Zhao, Y, Fry, E.E, Ren, J, Stuart, D.I.
登録日2020-06-17
公開日2020-07-08
最終更新日2021-12-22
実験手法ELECTRON MICROSCOPY (4.4 Å)
主引用文献Structural basis for the neutralization of SARS-CoV-2 by an antibody from a convalescent patient.
Nat.Struct.Mol.Biol., 27, 2020
6XEY
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BU of 6xey by Molmil
Cryo-EM structure of the SARS-CoV-2 spike glycoprotein bound to Fab 2-4
分子名称: 2-4 Heavy Chain, 2-4 Light Chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Rapp, M, Shapiro, L, Ho, D.D.
登録日2020-06-14
公開日2020-07-22
最終更新日2021-01-27
実験手法ELECTRON MICROSCOPY (3.25 Å)
主引用文献Potent neutralizing antibodies against multiple epitopes on SARS-CoV-2 spike.
Nature, 584, 2020
6XR8
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BU of 6xr8 by Molmil
Distinct conformational states of SARS-CoV-2 spike protein
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Zhang, J, Cai, Y.F, Xiao, T.S, Peng, H.Q, Sterling, S.M, Walsh Jr, R.M, Rawson, S, Volloch, S.R, Chen, B.
登録日2020-07-11
公開日2020-07-22
最終更新日2020-11-25
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Distinct conformational states of SARS-CoV-2 spike protein.
Science, 369, 2020
6XS6
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BU of 6xs6 by Molmil
SARS-CoV-2 Spike D614G variant, minus RBD
分子名称: Spike glycoprotein
著者Wang, X, Egri, S.B, Dudkina, N, Luban, J, Shen, K.
登録日2020-07-15
公開日2020-07-22
最終更新日2020-11-11
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant.
Cell, 183, 2020
6ZOJ
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BU of 6zoj by Molmil
SARS-CoV-2-Nsp1-40S complex, composite map
分子名称: 18S ribosomal RNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ...
著者Schubert, K, Karousis, E.D, Jomaa, A, Scaiola, A, Echeverria, B, Gurzeler, L.-A, Leibundgut, M.L, Thiel, V, Muehlemann, O, Ban, N.
登録日2020-07-07
公開日2020-07-22
最終更新日2021-02-10
実験手法ELECTRON MICROSCOPY (2.8 Å)
主引用文献SARS-CoV-2 Nsp1 binds the ribosomal mRNA channel to inhibit translation.
Nat.Struct.Mol.Biol., 27, 2020
6ZOX
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BU of 6zox by Molmil
Structure of Disulphide-stabilized SARS-CoV-2 Spike Protein Trimer (x2 disulphide-bond mutant, G413C, V987C, single Arg S1/S2 cleavage site)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
著者Xiong, X, Qu, K, Scheres, S.H.W, Briggs, J.A.G.
登録日2020-07-08
公開日2020-07-22
最終更新日2021-06-02
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献A thermostable, closed SARS-CoV-2 spike protein trimer.
Nat.Struct.Mol.Biol., 27, 2020
6ZOY
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BU of 6zoy by Molmil
Structure of Disulphide-stabilized SARS-CoV-2 Spike Protein Trimer (x1 disulphide-bond mutant, S383C, D985C, K986P, V987P, single Arg S1/S2 cleavage site) in Closed State
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
著者Xiong, X, Qu, K, Scheres, S.H.W, Briggs, J.A.G.
登録日2020-07-08
公開日2020-07-22
最終更新日2021-06-02
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献A thermostable, closed SARS-CoV-2 spike protein trimer.
Nat.Struct.Mol.Biol., 27, 2020
6ZP0
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BU of 6zp0 by Molmil
Structure of SARS-CoV-2 Spike Protein Trimer (single Arg S1/S2 cleavage site) in Closed State
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
著者Xiong, X, Qu, K, Scheres, S.H.W, Briggs, J.A.G.
登録日2020-07-08
公開日2020-07-22
最終更新日2021-06-02
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献A thermostable, closed SARS-CoV-2 spike protein trimer.
Nat.Struct.Mol.Biol., 27, 2020
6ZP1
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BU of 6zp1 by Molmil
Structure of SARS-CoV-2 Spike Protein Trimer (K986P, V987P, single Arg S1/S2 cleavage site) in Closed State
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
著者Xiong, X, Qu, K, Scheres, S.H.W, Briggs, J.A.G.
登録日2020-07-08
公開日2020-07-22
最終更新日2021-06-02
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献A thermostable, closed SARS-CoV-2 spike protein trimer.
Nat.Struct.Mol.Biol., 27, 2020

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