Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody CC12.3

Summary for 6XC4

Related6XC2 6XC3
DescriptorSpike protein S1, CC12.3 heavy chain, CC12.3 light chain, ... (5 entities in total)
Functional Keywordsantibody, sars-cov-2, coronavirus, spike, immune system, immune system-viral protein complex, immune system/viral protein
Biological sourceSevere acute respiratory syndrome coronavirus 2 (2019-nCoV)
Total number of polymer chains6
Total molecular weight146251.34
Yuan, M.,Liu, H.,Wu, N.C.,Zhu, X.,Wilson, I.A. (deposition date: 2020-06-08, release date: 2020-07-08, Last modification date: 2020-07-29)
Primary citation
Yuan, M.,Liu, H.,Wu, N.C.,Lee, C.D.,Zhu, X.,Zhao, F.,Huang, D.,Yu, W.,Hua, Y.,Tien, H.,Rogers, T.F.,Landais, E.,Sok, D.,Jardine, J.G.,Burton, D.R.,Wilson, I.A.
Structural basis of a public antibody response to SARS-CoV-2.
Biorxiv, 2020
PubMed: 32577642 (PDB entries with the same primary citation)
DOI: 10.1101/2020.06.08.141267
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2194 0.2% 1.7% 4.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-08-12