6XC4

Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody CC12.3

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, Z	Spike protein S1	polymer	231	26095.3	2	UniProt (P0DTC2) Pfam (PF09408) In PDB	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)
2	H, X	CC12.3 heavy chain	polymer	220	23377.2	2		Homo sapiens
3	L, Y	CC12.3 light chain	polymer	215	23432.0	2		Homo sapiens
4	A, Z	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)
5		water	water		18.0	649	Chemie (HOH)

Sequence modifications

A, Z: 319 - 541 (UniProt: P0DTC2)

PDB	External Database	Details
Ser 542	-	expression tag
Gly 543	-	expression tag
His 544	-	expression tag
His 545	-	expression tag
His 546	-	expression tag
His 547	-	expression tag
His 548	-	expression tag
His 549	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	145808.9
Non-Polymers*	Number of molecules	2
	Total formula weight	442.4
All*	Total formula weight	146251.3

*Water molecules are not included.