Structure of Disulphide-stabilized SARS-CoV-2 Spike Protein Trimer (x1 disulphide-bond mutant, S383C, D985C, K986P, V987P, single Arg S1/S2 cleavage site) in Closed State

Summary for 6ZOY

EMDB information11330
DescriptorSpike glycoprotein, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
Functional Keywordscoronavirus, sars-cov-2, spike protein, s protein, s antigen, covid-19, receptor binding, membrane fusion, vaccine design, viral protein
Biological sourceSevere acute respiratory syndrome coronavirus 2 (2019-nCoV)
Total number of polymer chains3
Total molecular weight429352.85
Xiong, X.,Qu, K.,Scheres, S.H.W.,Briggs, J.A.G. (deposition date: 2020-07-08, release date: 2020-07-22, Last modification date: 2020-08-12)
Primary citation
Xiong, X.,Qu, K.,Ciazynska, K.A.,Hosmillo, M.,Carter, A.P.,Ebrahimi, S.,Ke, Z.,Scheres, S.H.W.,Bergamaschi, L.,Grice, G.L.,Zhang, Y.,Nathan, J.A.,Baker, S.,James, L.C.,Baxendale, H.E.,Goodfellow, I.,Doffinger, R.,Briggs, J.A.G.
A thermostable, closed SARS-CoV-2 spike protein trimer.
Nat.Struct.Mol.Biol., 2020
PubMed: 32737467 (PDB entries with the same primary citation)
DOI: 10.1038/s41594-020-0478-5
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliers4 0.3% 0.3%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all EM structures
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PDB entries from 2020-08-12