6XCM

Structure of the SARS-CoV-2 spike glycoprotein in complex with the C105 neutralizing antibody Fab fragment (state 1)

Summary for 6XCM

EMDB information22127 22128
DescriptorSpike glycoprotein, C105 Fab Heavy Chain, C105 Fab Light Chain, ... (6 entities in total)
Functional Keywordssars-cov-2, spike glycoprotein, covid-19, monoclonal neutralizing antibody, fabs, nsempem, viral protein-immune system complex, viral protein/immune system
Biological sourceSevere acute respiratory syndrome coronavirus 2 (2019-nCoV)
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Total number of polymer chains7
Total molecular weight527317.39
Authors
Barnes, C.O.,Bjorkman, P.J. (deposition date: 2020-06-08, release date: 2020-07-01)
Primary citation
Barnes, C.O.,West, A.P.,Huey-Tubman, K.E.,Hoffmann, M.A.G.,Sharaf, N.G.,Hoffman, P.R.,Koranda, N.,Gristick, H.B.,Gaebler, C.,Muecksch, F.,Lorenzi, J.C.C.,Finkin, S.,Hagglof, T.,Hurley, A.,Millard, K.G.,Weisblum, Y.,Schmidt, F.,Hatziioannou, T.,Bieniasz, P.D.,Caskey, M.,Robbiani, D.F.,Nussenzweig, M.C.,Bjorkman, P.J.
Structures of human antibodies bound to SARS-CoV-2 spike reveal common epitopes and recurrent features of antibodies
Cell(Cambridge,Mass.), 2020
DOI: 10.1016/j.cell.2020.06.025
MImport into Mendeley
Experimental method
ELECTRON MICROSCOPY
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Structure validation

ClashscoreRamachandran outliersSidechain outliers15 0.1% 5.7%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all EM structures
Download full validation reportDownload