Author results

2PLT
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STRUCTURE DETERMINATION OF PLASTOCYANIN FROM A CRYSTAL SPECIMEN WITH HEMIHEDRAL TWINNING FRACTION OF ONE-HALF
Descriptor:PLASTOCYANIN, COPPER (II) ION, CALCIUM ION
Authors:Redinbo, M.R., Merchant, S., Yeates, T.O.
Deposit date:1993-05-06
Release date:1993-10-31
Last modified:2012-07-18
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:The 1.5-A crystal structure of plastocyanin from the green alga Chlamydomonas reinhardtii.
Biochemistry, 32, 1993
1A31
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HUMAN RECONSTITUTED DNA TOPOISOMERASE I IN COVALENT COMPLEX WITH A 22 BASE PAIR DNA DUPLEX
Descriptor:DNA (5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*5IUP*5IU*TP*GP*AP*AP*AP*AP*AP*5IUP*5IUP*5IUP*5IUP*T)-3'), DNA (5'-D(*AP*AP*AP*AP*AP*TP*5IUP*5IUP*5IUP*5IUP*CP*AP*AP*AP*GP*TP*CP*TP*TP*TP*TP*T)-3'), PROTEIN (TOPOISOMERASE I)
Authors:Redinbo, M.R., Stewart, L., Kuhn, P., Champoux, J.J., Hol, W.G.J.
Deposit date:1998-01-27
Release date:1998-08-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA.
Science, 279, 1998
1A35
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HUMAN TOPOISOMERASE I/DNA COMPLEX
Descriptor:DNA (5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*TP*AP*GP*AP*AP*AP*AP*AP*(BRU)P*(BRU)P*TP*TP*T)-3'), DNA (5'-D(*AP*AP*AP*AP*AP*TP*+UP*+UP*+UP*+UP*CP*+UP*AP*AP*GP*TP*CP*TP*TP*TP*+ UP*T)-3'), PROTEIN (DNA TOPOISOMERASE I)
Authors:Redinbo, M.R., Stewart, L., Kuhn, P., Champoux, J.J., Hol, W.G.
Deposit date:1998-01-29
Release date:1998-08-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA.
Science, 279, 1998
1EJ9
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CRYSTAL STRUCTURE OF HUMAN TOPOISOMERASE I DNA COMPLEX
Descriptor:DNA (5'-D(*C*AP*AP*AP*AP*AP*GP*AP*CP*TP*CP*AP*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3'), DNA (5'-D(*C*AP*AP*AP*AP*AP*TP*TP*TP*TP*TP*CP*TP*GP*AP*GP*TP*CP*TP*TP*TP*TP*T)-3'), DNA TOPOISOMERASE I
Authors:Redinbo, M.R., Champoux, J.J., Hol, W.G.
Deposit date:2000-03-01
Release date:2000-08-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Novel insights into catalytic mechanism from a crystal structure of human topoisomerase I in complex with DNA.
Biochemistry, 39, 2000
3HX6
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CRYSTAL STRUCTURE OF PSEUDOMONAS AERUGINOSA PILY1 C-TERMINAL DOMAIN
Descriptor:Type 4 fimbrial biogenesis protein PilY1, CALCIUM ION
Authors:Redinbo, M.R., Orans, J.
Deposit date:2009-06-19
Release date:2010-01-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure analysis reveals Pseudomonas PilY1 as an essential calcium-dependent regulator of bacterial surface motility.
Proc.Natl.Acad.Sci.USA, 107, 2010
3L57
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CRYSTAL STRUCTURE OF THE PLASMID PCU1 TRAI RELAXASE DOMAIN
Descriptor:Mobilization protein TraI, MANGANESE (III) ION, 1,2-ETHANEDIOL, ...
Authors:Redinbo, M.R., Nash, R.P.
Deposit date:2009-12-21
Release date:2010-05-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.293 Å)
Cite:The mechanism and control of DNA transfer by the conjugative relaxase of resistance plasmid pCU1.
Nucleic Acids Res., 38, 2010
3L6T
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CRYSTAL STRUCTURE OF AN N-TERMINAL MUTANT OF THE PLASMID PCU1 TRAI RELAXASE DOMAIN
Descriptor:Mobilization protein TraI, CITRIC ACID, 1,2-ETHANEDIOL, ...
Authors:Redinbo, M.R., Nash, R.P.
Deposit date:2009-12-24
Release date:2010-05-19
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:The mechanism and control of DNA transfer by the conjugative relaxase of resistance plasmid pCU1.
Nucleic Acids Res., 38, 2010
4K59
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CRYSTAL STRUCTURE OF PSEUDOMONAS AERUGINOSA RSMF
Descriptor:RNA BINDING PROTEIN RsmF
Authors:Betts, L., Walton, W.G., Redinbo, M.R.
Deposit date:2013-04-14
Release date:2013-08-28
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:An unusual CsrA family member operates in series with RsmA to amplify posttranscriptional responses in Pseudomonas aeruginosa.
Proc.Natl.Acad.Sci.USA, 110, 2013
1A36
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TOPOISOMERASE I/DNA COMPLEX
Descriptor:DNA (5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*TP*AP*GP*AP*AP*AP*AP*A P*TP*TP*TP*TP*T)- 3'), DNA (5'-D(*AP*AP*AP*AP*AP*TP*TP*TP*TP*TP*CP*TP*AP*AP*GP*TP*C P*TP*TP*TP*TP*T)- 3'), TOPOISOMERASE I
Authors:Stewart, L., Redinbo, M.R., Qiu, X., Champoux, J.J., Hol, W.G.J.
Deposit date:1998-01-29
Release date:1998-08-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:A model for the mechanism of human topoisomerase I.
Science, 279, 1998
1ILG
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CRYSTAL STRUCTURE OF APO HUMAN PREGNANE X RECEPTOR LIGAND BINDING DOMAIN
Descriptor:ORPHAN NUCLEAR RECEPTOR PXR
Authors:Watkins, R.E., Redinbo, M.R.
Deposit date:2001-05-08
Release date:2001-06-27
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity.
Science, 292, 2001
1ILH
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CRYSTAL STRUCTURE OF HUMAN PREGNANE X RECEPTOR LIGAND BINDING DOMAIN BOUND TO SR12813
Descriptor:ORPHAN NUCLEAR RECEPTOR PXR, [2-(3,5-DI-TERT-BUTYL-4-HYDROXY-PHENYL)-1-(DIETHOXY-PHOSPHORYL)-VINYL]-PHOSPHONIC ACID DIETHLYL ESTER
Authors:Watkins, R.E., Redinbo, M.R.
Deposit date:2001-05-08
Release date:2001-06-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.76 Å)
Cite:The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity.
Science, 292, 2001
1K4Y
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CRYSTAL STRUCTURE OF RABBIT LIVER CARBOXYLESTERASE IN COMPLEX WITH 4-PIPERIDINO-PIPERIDINE
Descriptor:LIVER CARBOXYLESTERASE, N-ACETYL-D-GLUCOSAMINE, ALPHA-D-MANNOSE, ...
Authors:Bencharit, S., Morton, C.L., Howard-Williams, E.L., Danks, M.K., Potter, P.M., Redinbo, M.R.
Deposit date:2001-10-09
Release date:2002-05-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural insights into CPT-11 activation by mammalian carboxylesterases.
Nat.Struct.Biol., 9, 2002
1LPQ
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HUMAN DNA TOPOISOMERASE I (70 KDA) IN NON-COVALENT COMPLEX WITH A 22 BASE PAIR DNA DUPLEX CONTAINING AN 8-OXOG LESION
Descriptor:5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*TP*(8OG)P*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', 5'-D(*AP*AP*AP*AP*AP*TP*TP*TP*TP*TP*CP*CP*AP*AP*GP*TP*CP*TP*TP*TP*TP*T)-3', DNA topoisomerase I
Authors:Lesher, D.T., Pommier, Y., Stewart, L., Redinbo, M.R.
Deposit date:2002-05-08
Release date:2002-08-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.14 Å)
Cite:8-Oxoguanine rearranges the active site of human topoisomerase I
Proc.Natl.Acad.Sci.USA, 99, 2002
1M13
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CRYSTAL STRUCTURE OF THE HUMAN PREGANE X RECEPTOR LIGAND BINDING DOMAIN IN COMPLEX WITH HYPERFORIN, A CONSTITUENT OF ST. JOHN'S WORT
Descriptor:Orphan Nuclear Receptor PXR, 4-HYDROXY-5-ISOBUTYRYL-6-METHYL-1,3,7-TRIS-(3-METHYL-BUT-2-ENYL)-6-(4-METHYL-PENT-3-ENYL)-BICYCLO[3.3.1]NON-3-ENE-2,9-DIONE
Authors:Watkins, R.E., Maglich, J.M., Moore, L.B., Wisely, G.B., Noble, S.M., Davis-Searles, P.R., Lambert, M.H., Kliewer, S.A., Redinbo, M.R.
Deposit date:2002-06-17
Release date:2003-03-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:2.1 A Crystal Structure of Human PXR in Complex with the St. John's Wort Compound Hyperforin
Biochemistry, 42, 2003
1MX1
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CRYSTAL STRUCTURE OF HUMAN LIVER CARBOXYLESTERASE IN COMPLEX WITH TACRINE
Descriptor:liver Carboxylesterase I, N-ACETYL-D-GLUCOSAMINE, O-SIALIC ACID, ...
Authors:Bencharit, S., Morton, C.L., Hyatt, J.L., Kuhn, P., Danks, M.K., Potter, P.M., Redinbo, M.R.
Deposit date:2002-10-01
Release date:2003-04-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structure of Human Carboxylesterase 1 Complexed with the Alzheimer's Drug Tacrine: From Binding Promiscuity to Selective Inhibition
CHEM.BIOL., 10, 2003
1MX5
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CRYSTAL STRUCTURE OF HUMAN LIVER CARBOXYLESTERASE IN COMPLEXED WITH HOMATROPINE, A COCAINE ANALOGUE
Descriptor:liver Carboxylesterase I, N-ACETYL-D-GLUCOSAMINE, O-SIALIC ACID, ...
Authors:Bencharit, S., Morton, C.L., Xue, Y., Potter, P.M., Redinbo, M.R.
Deposit date:2002-10-01
Release date:2003-04-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Basis of Heroin and Cocaine Metabolism by a Promiscuous Human Drug-Processing Enzyme
Nat.Struct.Biol., 10, 2003
1MX9
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CRYSTAL STRUCTURE OF HUMAN LIVER CARBOXYLESTERASE IN COMPLEXED WITH NALOXONE METHIODIDE, A HEROIN ANALOGUE
Descriptor:liver Carboxylesterase I, N-ACETYL-D-GLUCOSAMINE, (5A,17R)-4,5-EPOXY-3,14-DIHYDROXY-17-METHYL-6-OXO-17-(2-PROPENYL)-MORPHINANIUM
Authors:Bencharit, S., Morton, C.L., Xue, Y., Potter, P.M., Redinbo, M.R.
Deposit date:2002-10-01
Release date:2003-04-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural Basis of Heroin and Cocaine Metabolism by a Promiscuous Human Drug-Processing Enzyme
Nat.Struct.Biol., 10, 2003
1NH3
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HUMAN TOPOISOMERASE I ARA-C COMPLEX
Descriptor:5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*UP*(UBB))-3', 5'-D(*(GNG)P*GP*AP*AP*AP*AP*AP*UP*UP*UP*UP*T)-3', 5'-D(*AP*AP*AP*AP*AP*TP*UP*UP*UP*UP*CP*(CAR)P*AP*AP*GP*UP*CP*UP*UP*UP*UP*T)-3', ...
Authors:Chrencik, J.E., Burgin, A.B., Pommier, Y., Stewart, L., Redinbo, M.R.
Deposit date:2002-12-18
Release date:2003-03-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural Impact of the Leukemia Drug 1-beta-D-Arabinofuranosylcytosine (Ara-C) on the Covalent Human Topoisomerase I-DNA Complex
J.Biol.Chem., 278, 2003
1NRL
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CRYSTAL STRUCTURE OF THE HUMAN PXR-LBD IN COMPLEX WITH AN SRC-1 COACTIVATOR PEPTIDE AND SR12813
Descriptor:Orphan nuclear receptor PXR, Nuclear Receptor Coactivator 1 isoform 3, [2-(3,5-DI-TERT-BUTYL-4-HYDROXY-PHENYL)-1-(DIETHOXY-PHOSPHORYL)-VINYL]-PHOSPHONIC ACID DIETHLYL ESTER
Authors:Watkins, R.E., Davis-Searles, P.R., Lambert, M.H., Redinbo, M.R.
Deposit date:2003-01-25
Release date:2003-08-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Coactivator binding promotes the specific interaction between ligand and the pregnane X receptor
J.Mol.Biol., 331, 2003
1RR8
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STRUCTURAL MECHANISMS OF CAMPTOTHECIN RESISTANCE BY MUTATIONS IN HUMAN TOPOISOMERASE I
Descriptor:5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*T*GP*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', 5'-D(*AP*AP*AP*AP*AP*TP*TP*TP*TP*TP*CP*CP*AP*AP*GP*TP*CP*TP*TP*TP*TP*T)-3', DNA topoisomerase I, ...
Authors:Chrencik, J.E., Staker, B.L., Burgin, A.B., Stewart, L., Redinbo, M.R.
Deposit date:2003-12-08
Release date:2004-07-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Mechanisms of camptothecin resistance by human topoisomerase I mutations
J.Mol.Biol., 339, 2004
1RRJ
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STRUCTURAL MECHANISMS OF CAMPTOTHECIN RESISTANCE BY MUTATIONS IN HUMAN TOPOISOMERASE I
Descriptor:5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*T*GP*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', 5'-D(*AP*AP*AP*AP*AP*TP*TP*TP*TP*TP*CP*CP*AP*AP*GP*TP*CP*TP*TP*TP*TP*T)-3', DNA topoisomerase I, ...
Authors:Chrencik, J.E., Staker, B.L., Burgin, A.B., Stewart, L., Redinbo, M.R.
Deposit date:2003-12-08
Release date:2004-07-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Mechanisms of camptothecin resistance by human topoisomerase I mutations
J.Mol.Biol., 339, 2004
1SKX
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STRUCTURAL DISORDER IN THE COMPLEX OF HUMAN PXR AND THE MACROLIDE ANTIBIOTIC RIFAMPICIN
Descriptor:Orphan nuclear receptor PXR, RIFAMPICIN
Authors:Chrencik, J.E., Xue, Y., Orans, J.O., Redinbo, M.R.
Deposit date:2004-03-05
Release date:2005-03-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural disorder in the complex of human pregnane x receptor and the macrolide antibiotic rifampicin
Mol.Endocrinol., 19, 2005
1YA4
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CRYSTAL STRUCTURE OF HUMAN LIVER CARBOXYLESTERASE 1 IN COMPLEX WITH TAMOXIFEN
Descriptor:CES1 protein, N-ACETYL-D-GLUCOSAMINE, O-SIALIC ACID, ...
Authors:Fleming, C.D., Bencharit, S., Edwards, C.C., Hyatt, J.L., Morton, C.L., Howard-Williams, E.L., Potter, P.M., Redinbo, M.R.
Deposit date:2004-12-17
Release date:2005-08-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural insights into drug processing by human carboxylesterase 1: tamoxifen, mevastatin, and inhibition by benzil.
J.Mol.Biol., 352, 2005
1YA8
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CRYSTAL STRUCTURE OF HUMAN LIVER CARBOXYLESTERASE IN COMPLEX WITH CLEAVAGE PRODUCTS OF MEVASTATIN
Descriptor:CES1 protein, N-ACETYL-D-GLUCOSAMINE, O-SIALIC ACID, ...
Authors:Fleming, C.D., Bencharit, S., Edwards, C.C., Hyatt, J.L., Morton, C.L., Howard-Williams, E.L., Potter, P.M., Redinbo, M.R.
Deposit date:2004-12-17
Release date:2005-08-02
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural insights into drug processing by human carboxylesterase 1: tamoxifen, mevastatin, and inhibition by benzil.
J.Mol.Biol., 352, 2005
1YAH
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CRYSTAL STRUCTURE OF HUMAN LIVER CARBOXYLESTERASE COMPLEXED TO ETYL ACETATE; A FATTY ACID ETHYL ESTER ANALOGUE
Descriptor:CES1 protein, N-ACETYL-D-GLUCOSAMINE, O-SIALIC ACID, ...
Authors:Fleming, C.D., Bencahrit, S., Edwards, C.C., Hyatt, J.L., Morton, C.L., Howard-Williams, E.L., Potter, P.M., Redinbo, M.R.
Deposit date:2004-12-17
Release date:2005-08-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural insights into drug processing by human carboxylesterase 1: tamoxifen, mevastatin, and inhibition by benzil.
J.Mol.Biol., 352, 2005