7U4C

Borrelia burgdorferi HtpG N-terminal domain (1-228) in complex with BX-2819

Summary for 7U4C

• Entry DOI: 10.2210/pdb7u4c/pdb
• Descriptor: Chaperone protein HtpG, ethyl (4-{3-[2,4-dihydroxy-5-(1-methylethyl)phenyl]-5-sulfanyl-4H-1,2,4-triazol-4-yl}benzyl)carbamate (3 entities in total)
• Functional Keywords: inhibitor, chaperone-inhibitor complex, chaperone/inhibitor
• Biological source: Borreliella burgdorferi (Lyme disease spirochete)
• Total number of polymer chains: 2
• Total formula weight: 55062.58

Authors

Kowalewski, M.E.,Lietzan, A.,Haystead, T.,Redinbo, M.R. (deposition date: 2022-02-28, release date: 2023-03-08, Last modification date: 2023-11-15)

• Primary citation: Carlson, D.L.,Kowalewski, M.,Bodoor, K.,Lietzan, A.D.,Hughes, P.F.,Gooden, D.,Loiselle, D.L.,Alcorta, D.,Dingman, Z.,Mueller, E.A.,Irnov, I.,Modla, S.,Chaya, T.,Caplan, J.,Embers, M.,Miller, J.C.,Jacobs-Wagner, C.,Redinbo, M.R.,Spector, N.,Haystead, T.A.J.; Targeting Borrelia burgdorferi HtpG with a berserker molecule, a strategy for anti-microbial development.; Cell Chem Biol, 2023; PubMed: 37918401; DOI: 10.1016/j.chembiol.2023.10.004

Experimental method

X-RAY DIFFRACTION (2.28 Å)